2QPO
Thermotoga Maritima Thymidine Kinase in the apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004797 | molecular_function | thymidine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046104 | biological_process | thymidine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071897 | biological_process | DNA biosynthetic process |
| B | 0004797 | molecular_function | thymidine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046104 | biological_process | thymidine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071897 | biological_process | DNA biosynthetic process |
| C | 0004797 | molecular_function | thymidine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046104 | biological_process | thymidine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0071897 | biological_process | DNA biosynthetic process |
| D | 0004797 | molecular_function | thymidine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046104 | biological_process | thymidine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 201 |
| Chain | Residue |
| A | CYS140 |
| A | CYS143 |
| A | CYS173 |
| A | CYS176 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | TYR13 |
| A | SER14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 202 |
| Chain | Residue |
| B | CYS140 |
| B | CYS143 |
| B | CYS173 |
| B | CYS176 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | TYR13 |
| B | SER14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| B | HOH314 |
| B | HOH315 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 204 |
| Chain | Residue |
| C | CYS140 |
| C | CYS143 |
| C | CYS173 |
| C | CYS176 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | TYR13 |
| C | SER14 |
| C | GLY15 |
| C | LYS16 |
| C | THR17 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 203 |
| Chain | Residue |
| D | CYS140 |
| D | CYS143 |
| D | CYS173 |
| D | CYS176 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 304 |
| Chain | Residue |
| D | TYR13 |
| D | SER14 |
| D | GLY15 |
| D | LYS16 |
| D | THR17 |
| D | HOH307 |
Functional Information from PROSITE/UniProt
| site_id | PS00603 |
| Number of Residues | 14 |
| Details | TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GgqEkYiAvCRdCY |
| Chain | Residue | Details |
| A | GLY164-TYR177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU84 | |
| B | GLU84 | |
| C | GLU84 | |
| D | GLU84 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY10 | |
| B | GLY10 | |
| B | HIS53 | |
| B | HIS115 | |
| B | CYS140 | |
| B | CYS143 | |
| B | ILE161 | |
| B | TYR169 | |
| B | CYS173 | |
| B | CYS176 | |
| C | GLY10 | |
| A | HIS53 | |
| C | HIS53 | |
| C | HIS115 | |
| C | CYS140 | |
| C | CYS143 | |
| C | ILE161 | |
| C | TYR169 | |
| C | CYS173 | |
| C | CYS176 | |
| D | GLY10 | |
| D | HIS53 | |
| A | HIS115 | |
| D | HIS115 | |
| D | CYS140 | |
| D | CYS143 | |
| D | ILE161 | |
| D | TYR169 | |
| D | CYS173 | |
| D | CYS176 | |
| A | CYS140 | |
| A | CYS143 | |
| A | ILE161 | |
| A | TYR169 | |
| A | CYS173 | |
| A | CYS176 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP83 | |
| B | ASP83 | |
| C | ASP83 | |
| D | ASP83 |
