2QPO

Thermotoga Maritima Thymidine Kinase in the apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004797	molecular_function	thymidine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006259	biological_process	DNA metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042802	molecular_function	identical protein binding
A	0046104	biological_process	thymidine metabolic process
A	0046872	molecular_function	metal ion binding
A	0071897	biological_process	DNA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004797	molecular_function	thymidine kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006259	biological_process	DNA metabolic process
B	0008270	molecular_function	zinc ion binding
B	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042802	molecular_function	identical protein binding
B	0046104	biological_process	thymidine metabolic process
B	0046872	molecular_function	metal ion binding
B	0071897	biological_process	DNA biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004797	molecular_function	thymidine kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006259	biological_process	DNA metabolic process
C	0008270	molecular_function	zinc ion binding
C	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0042802	molecular_function	identical protein binding
C	0046104	biological_process	thymidine metabolic process
C	0046872	molecular_function	metal ion binding
C	0071897	biological_process	DNA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004797	molecular_function	thymidine kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006259	biological_process	DNA metabolic process
D	0008270	molecular_function	zinc ion binding
D	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0042802	molecular_function	identical protein binding
D	0046104	biological_process	thymidine metabolic process
D	0046872	molecular_function	metal ion binding
D	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	CYS140
A	CYS143
A	CYS173
A	CYS176

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	TYR13
A	SER14
A	GLY15
A	LYS16
A	THR17

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 202

Chain	Residue
B	CYS140
B	CYS143
B	CYS173
B	CYS176

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	TYR13
B	SER14
B	GLY15
B	LYS16
B	THR17
B	HOH314
B	HOH315

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 204

Chain	Residue
C	CYS140
C	CYS143
C	CYS173
C	CYS176

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
C	TYR13
C	SER14
C	GLY15
C	LYS16
C	THR17

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 203

Chain	Residue
D	CYS140
D	CYS143
D	CYS173
D	CYS176

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 304

Chain	Residue
D	TYR13
D	SER14
D	GLY15
D	LYS16
D	THR17
D	HOH307

---

Functional Information from PROSITE/UniProt

site_id	PS00603
Number of Residues	14
Details	TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GgqEkYiAvCRdCY

Chain	Residue	Details
A	GLY164-TYR177

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	52
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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