2QLP
Bifunctional dCTP deaminase:dUTPase from Mycobacterium tuberculosis, apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006229 | biological_process | dUTP biosynthetic process |
| A | 0008829 | molecular_function | dCTP deaminase activity |
| B | 0006229 | biological_process | dUTP biosynthetic process |
| B | 0008829 | molecular_function | dCTP deaminase activity |
| C | 0006229 | biological_process | dUTP biosynthetic process |
| C | 0008829 | molecular_function | dCTP deaminase activity |
| D | 0006229 | biological_process | dUTP biosynthetic process |
| D | 0008829 | molecular_function | dCTP deaminase activity |
| E | 0006229 | biological_process | dUTP biosynthetic process |
| E | 0008829 | molecular_function | dCTP deaminase activity |
| F | 0006229 | biological_process | dUTP biosynthetic process |
| F | 0008829 | molecular_function | dCTP deaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE A 162 |
| Chain | Residue |
| A | ARG106 |
| A | LEU107 |
| C | ARG41 |
| C | LEU81 |
| C | SER83 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE 1PE A 163 |
| Chain | Residue |
| A | ARG41 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 1PE B 162 |
| Chain | Residue |
| C | ARG106 |
| B | ARG41 |
| B | SER83 |
| B | THR127 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 1PE C 162 |
| Chain | Residue |
| C | GLN65 |
| C | VAL67 |
| C | ASP68 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 1PE D 162 |
| Chain | Residue |
| D | ARG41 |
| D | GLY82 |
| D | SER83 |
| E | ARG106 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 1PE E 162 |
| Chain | Residue |
| E | ARG41 |
| E | LEU81 |
| E | GLY82 |
| E | THR127 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 1PE F 162 |
| Chain | Residue |
| D | ARG106 |
| F | ARG41 |
| F | SER83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P28248","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"NOV-2011","submissionDatabase":"PDB data bank","title":"Dttp inhibition of the bifunctional Dctp deaminase- dutpase from Mycobacterium tuberculosis is pH dependent: kinetic analyses and crystal structure of A115V Variant.","authors":["Lovgreen M.N.","Harris P.","Ucar E.","Willemoes M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18164314","evidenceCode":"ECO:0000305"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"NOV-2011","submissionDatabase":"PDB data bank","title":"Dttp inhibition of the bifunctional Dctp deaminase- dutpase from Mycobacterium tuberculosis is pH dependent: kinetic analyses and crystal structure of A115V Variant.","authors":["Lovgreen M.N.","Harris P.","Ucar E.","Willemoes M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Important for bifunctional activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18164314","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| A | GLY121 | |
| A | ASP119 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| B | GLY121 | |
| B | ASP119 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| C | GLY121 | |
| C | ASP119 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| D | GLY121 | |
| D | ASP119 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| E | GLY121 | |
| E | ASP119 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| F | GLY121 | |
| F | ASP119 |
