2QL6

human nicotinamide riboside kinase (NRK1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006741	biological_process	NADP+ biosynthetic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0046495	biological_process	nicotinamide riboside metabolic process
A	0046872	molecular_function	metal ion binding
A	0050262	molecular_function	ribosylnicotinamide kinase activity
A	0061769	molecular_function	ribosylnicotinate kinase activity
A	1901847	biological_process	nicotinate metabolic process
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006741	biological_process	NADP+ biosynthetic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD+ metabolic process
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0046495	biological_process	nicotinamide riboside metabolic process
B	0046872	molecular_function	metal ion binding
B	0050262	molecular_function	ribosylnicotinamide kinase activity
B	0061769	molecular_function	ribosylnicotinate kinase activity
B	1901847	biological_process	nicotinate metabolic process
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006741	biological_process	NADP+ biosynthetic process
C	0009435	biological_process	NAD+ biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD+ metabolic process
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0046495	biological_process	nicotinamide riboside metabolic process
C	0046872	molecular_function	metal ion binding
C	0050262	molecular_function	ribosylnicotinamide kinase activity
C	0061769	molecular_function	ribosylnicotinate kinase activity
C	1901847	biological_process	nicotinate metabolic process
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006741	biological_process	NADP+ biosynthetic process
D	0009435	biological_process	NAD+ biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD+ metabolic process
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0046495	biological_process	nicotinamide riboside metabolic process
D	0046872	molecular_function	metal ion binding
D	0050262	molecular_function	ribosylnicotinamide kinase activity
D	0061769	molecular_function	ribosylnicotinate kinase activity
D	1901847	biological_process	nicotinate metabolic process
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006741	biological_process	NADP+ biosynthetic process
E	0009435	biological_process	NAD+ biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD+ metabolic process
E	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
E	0046495	biological_process	nicotinamide riboside metabolic process
E	0046872	molecular_function	metal ion binding
E	0050262	molecular_function	ribosylnicotinamide kinase activity
E	0061769	molecular_function	ribosylnicotinate kinase activity
E	1901847	biological_process	nicotinate metabolic process
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006741	biological_process	NADP+ biosynthetic process
F	0009435	biological_process	NAD+ biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD+ metabolic process
F	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
F	0046495	biological_process	nicotinamide riboside metabolic process
F	0046872	molecular_function	metal ion binding
F	0050262	molecular_function	ribosylnicotinamide kinase activity
F	0061769	molecular_function	ribosylnicotinate kinase activity
F	1901847	biological_process	nicotinate metabolic process
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006741	biological_process	NADP+ biosynthetic process
G	0009435	biological_process	NAD+ biosynthetic process
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019363	biological_process	pyridine nucleotide biosynthetic process
G	0019674	biological_process	NAD+ metabolic process
G	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
G	0046495	biological_process	nicotinamide riboside metabolic process
G	0046872	molecular_function	metal ion binding
G	0050262	molecular_function	ribosylnicotinamide kinase activity
G	0061769	molecular_function	ribosylnicotinate kinase activity
G	1901847	biological_process	nicotinate metabolic process
H	0000166	molecular_function	nucleotide binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006741	biological_process	NADP+ biosynthetic process
H	0009435	biological_process	NAD+ biosynthetic process
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0019363	biological_process	pyridine nucleotide biosynthetic process
H	0019674	biological_process	NAD+ metabolic process
H	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
H	0046495	biological_process	nicotinamide riboside metabolic process
H	0046872	molecular_function	metal ion binding
H	0050262	molecular_function	ribosylnicotinamide kinase activity
H	0061769	molecular_function	ribosylnicotinate kinase activity
H	1901847	biological_process	nicotinate metabolic process
I	0000166	molecular_function	nucleotide binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006741	biological_process	NADP+ biosynthetic process
I	0009435	biological_process	NAD+ biosynthetic process
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0019363	biological_process	pyridine nucleotide biosynthetic process
I	0019674	biological_process	NAD+ metabolic process
I	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
I	0046495	biological_process	nicotinamide riboside metabolic process
I	0046872	molecular_function	metal ion binding
I	0050262	molecular_function	ribosylnicotinamide kinase activity
I	0061769	molecular_function	ribosylnicotinate kinase activity
I	1901847	biological_process	nicotinate metabolic process
J	0000166	molecular_function	nucleotide binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006741	biological_process	NADP+ biosynthetic process
J	0009435	biological_process	NAD+ biosynthetic process
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0019363	biological_process	pyridine nucleotide biosynthetic process
J	0019674	biological_process	NAD+ metabolic process
J	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
J	0046495	biological_process	nicotinamide riboside metabolic process
J	0046872	molecular_function	metal ion binding
J	0050262	molecular_function	ribosylnicotinamide kinase activity
J	0061769	molecular_function	ribosylnicotinate kinase activity
J	1901847	biological_process	nicotinate metabolic process
K	0000166	molecular_function	nucleotide binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006741	biological_process	NADP+ biosynthetic process
K	0009435	biological_process	NAD+ biosynthetic process
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0019363	biological_process	pyridine nucleotide biosynthetic process
K	0019674	biological_process	NAD+ metabolic process
K	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
K	0046495	biological_process	nicotinamide riboside metabolic process
K	0046872	molecular_function	metal ion binding
K	0050262	molecular_function	ribosylnicotinamide kinase activity
K	0061769	molecular_function	ribosylnicotinate kinase activity
K	1901847	biological_process	nicotinate metabolic process
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006741	biological_process	NADP+ biosynthetic process
L	0009435	biological_process	NAD+ biosynthetic process
L	0016301	molecular_function	kinase activity
L	0016740	molecular_function	transferase activity
L	0019363	biological_process	pyridine nucleotide biosynthetic process
L	0019674	biological_process	NAD+ metabolic process
L	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
L	0046495	biological_process	nicotinamide riboside metabolic process
L	0046872	molecular_function	metal ion binding
L	0050262	molecular_function	ribosylnicotinamide kinase activity
L	0061769	molecular_function	ribosylnicotinate kinase activity
L	1901847	biological_process	nicotinate metabolic process
M	0000166	molecular_function	nucleotide binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006741	biological_process	NADP+ biosynthetic process
M	0009435	biological_process	NAD+ biosynthetic process
M	0016301	molecular_function	kinase activity
M	0016740	molecular_function	transferase activity
M	0019363	biological_process	pyridine nucleotide biosynthetic process
M	0019674	biological_process	NAD+ metabolic process
M	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
M	0046495	biological_process	nicotinamide riboside metabolic process
M	0046872	molecular_function	metal ion binding
M	0050262	molecular_function	ribosylnicotinamide kinase activity
M	0061769	molecular_function	ribosylnicotinate kinase activity
M	1901847	biological_process	nicotinate metabolic process
N	0000166	molecular_function	nucleotide binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006741	biological_process	NADP+ biosynthetic process
N	0009435	biological_process	NAD+ biosynthetic process
N	0016301	molecular_function	kinase activity
N	0016740	molecular_function	transferase activity
N	0019363	biological_process	pyridine nucleotide biosynthetic process
N	0019674	biological_process	NAD+ metabolic process
N	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
N	0046495	biological_process	nicotinamide riboside metabolic process
N	0046872	molecular_function	metal ion binding
N	0050262	molecular_function	ribosylnicotinamide kinase activity
N	0061769	molecular_function	ribosylnicotinate kinase activity
N	1901847	biological_process	nicotinate metabolic process
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006741	biological_process	NADP+ biosynthetic process
O	0009435	biological_process	NAD+ biosynthetic process
O	0016301	molecular_function	kinase activity
O	0016740	molecular_function	transferase activity
O	0019363	biological_process	pyridine nucleotide biosynthetic process
O	0019674	biological_process	NAD+ metabolic process
O	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
O	0046495	biological_process	nicotinamide riboside metabolic process
O	0046872	molecular_function	metal ion binding
O	0050262	molecular_function	ribosylnicotinamide kinase activity
O	0061769	molecular_function	ribosylnicotinate kinase activity
O	1901847	biological_process	nicotinate metabolic process
P	0000166	molecular_function	nucleotide binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006741	biological_process	NADP+ biosynthetic process
P	0009435	biological_process	NAD+ biosynthetic process
P	0016301	molecular_function	kinase activity
P	0016740	molecular_function	transferase activity
P	0019363	biological_process	pyridine nucleotide biosynthetic process
P	0019674	biological_process	NAD+ metabolic process
P	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
P	0046495	biological_process	nicotinamide riboside metabolic process
P	0046872	molecular_function	metal ion binding
P	0050262	molecular_function	ribosylnicotinamide kinase activity
P	0061769	molecular_function	ribosylnicotinate kinase activity
P	1901847	biological_process	nicotinate metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QSY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---