Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2QL6

human nicotinamide riboside kinase (NRK1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006741	biological_process	NADP+ biosynthetic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0034317	molecular_function	nicotinate riboside kinase activity
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0046872	molecular_function	metal ion binding
A	0050262	molecular_function	ribosylnicotinamide kinase activity
A	0061769	molecular_function	ribosylnicotinate kinase activity
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006741	biological_process	NADP+ biosynthetic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD+ metabolic process
B	0034317	molecular_function	nicotinate riboside kinase activity
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0046872	molecular_function	metal ion binding
B	0050262	molecular_function	ribosylnicotinamide kinase activity
B	0061769	molecular_function	ribosylnicotinate kinase activity
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006741	biological_process	NADP+ biosynthetic process
C	0009435	biological_process	NAD+ biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD+ metabolic process
C	0034317	molecular_function	nicotinate riboside kinase activity
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0046872	molecular_function	metal ion binding
C	0050262	molecular_function	ribosylnicotinamide kinase activity
C	0061769	molecular_function	ribosylnicotinate kinase activity
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006741	biological_process	NADP+ biosynthetic process
D	0009435	biological_process	NAD+ biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD+ metabolic process
D	0034317	molecular_function	nicotinate riboside kinase activity
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0046872	molecular_function	metal ion binding
D	0050262	molecular_function	ribosylnicotinamide kinase activity
D	0061769	molecular_function	ribosylnicotinate kinase activity
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006741	biological_process	NADP+ biosynthetic process
E	0009435	biological_process	NAD+ biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD+ metabolic process
E	0034317	molecular_function	nicotinate riboside kinase activity
E	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
E	0046872	molecular_function	metal ion binding
E	0050262	molecular_function	ribosylnicotinamide kinase activity
E	0061769	molecular_function	ribosylnicotinate kinase activity
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006741	biological_process	NADP+ biosynthetic process
F	0009435	biological_process	NAD+ biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD+ metabolic process
F	0034317	molecular_function	nicotinate riboside kinase activity
F	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
F	0046872	molecular_function	metal ion binding
F	0050262	molecular_function	ribosylnicotinamide kinase activity
F	0061769	molecular_function	ribosylnicotinate kinase activity
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006741	biological_process	NADP+ biosynthetic process
G	0009435	biological_process	NAD+ biosynthetic process
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019363	biological_process	pyridine nucleotide biosynthetic process
G	0019674	biological_process	NAD+ metabolic process
G	0034317	molecular_function	nicotinate riboside kinase activity
G	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
G	0046872	molecular_function	metal ion binding
G	0050262	molecular_function	ribosylnicotinamide kinase activity
G	0061769	molecular_function	ribosylnicotinate kinase activity
H	0000166	molecular_function	nucleotide binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006741	biological_process	NADP+ biosynthetic process
H	0009435	biological_process	NAD+ biosynthetic process
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0019363	biological_process	pyridine nucleotide biosynthetic process
H	0019674	biological_process	NAD+ metabolic process
H	0034317	molecular_function	nicotinate riboside kinase activity
H	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
H	0046872	molecular_function	metal ion binding
H	0050262	molecular_function	ribosylnicotinamide kinase activity
H	0061769	molecular_function	ribosylnicotinate kinase activity
I	0000166	molecular_function	nucleotide binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006741	biological_process	NADP+ biosynthetic process
I	0009435	biological_process	NAD+ biosynthetic process
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0019363	biological_process	pyridine nucleotide biosynthetic process
I	0019674	biological_process	NAD+ metabolic process
I	0034317	molecular_function	nicotinate riboside kinase activity
I	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
I	0046872	molecular_function	metal ion binding
I	0050262	molecular_function	ribosylnicotinamide kinase activity
I	0061769	molecular_function	ribosylnicotinate kinase activity
J	0000166	molecular_function	nucleotide binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006741	biological_process	NADP+ biosynthetic process
J	0009435	biological_process	NAD+ biosynthetic process
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0019363	biological_process	pyridine nucleotide biosynthetic process
J	0019674	biological_process	NAD+ metabolic process
J	0034317	molecular_function	nicotinate riboside kinase activity
J	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
J	0046872	molecular_function	metal ion binding
J	0050262	molecular_function	ribosylnicotinamide kinase activity
J	0061769	molecular_function	ribosylnicotinate kinase activity
K	0000166	molecular_function	nucleotide binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006741	biological_process	NADP+ biosynthetic process
K	0009435	biological_process	NAD+ biosynthetic process
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0019363	biological_process	pyridine nucleotide biosynthetic process
K	0019674	biological_process	NAD+ metabolic process
K	0034317	molecular_function	nicotinate riboside kinase activity
K	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
K	0046872	molecular_function	metal ion binding
K	0050262	molecular_function	ribosylnicotinamide kinase activity
K	0061769	molecular_function	ribosylnicotinate kinase activity
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006741	biological_process	NADP+ biosynthetic process
L	0009435	biological_process	NAD+ biosynthetic process
L	0016301	molecular_function	kinase activity
L	0016740	molecular_function	transferase activity
L	0019363	biological_process	pyridine nucleotide biosynthetic process
L	0019674	biological_process	NAD+ metabolic process
L	0034317	molecular_function	nicotinate riboside kinase activity
L	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
L	0046872	molecular_function	metal ion binding
L	0050262	molecular_function	ribosylnicotinamide kinase activity
L	0061769	molecular_function	ribosylnicotinate kinase activity
M	0000166	molecular_function	nucleotide binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006741	biological_process	NADP+ biosynthetic process
M	0009435	biological_process	NAD+ biosynthetic process
M	0016301	molecular_function	kinase activity
M	0016740	molecular_function	transferase activity
M	0019363	biological_process	pyridine nucleotide biosynthetic process
M	0019674	biological_process	NAD+ metabolic process
M	0034317	molecular_function	nicotinate riboside kinase activity
M	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
M	0046872	molecular_function	metal ion binding
M	0050262	molecular_function	ribosylnicotinamide kinase activity
M	0061769	molecular_function	ribosylnicotinate kinase activity
N	0000166	molecular_function	nucleotide binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006741	biological_process	NADP+ biosynthetic process
N	0009435	biological_process	NAD+ biosynthetic process
N	0016301	molecular_function	kinase activity
N	0016740	molecular_function	transferase activity
N	0019363	biological_process	pyridine nucleotide biosynthetic process
N	0019674	biological_process	NAD+ metabolic process
N	0034317	molecular_function	nicotinate riboside kinase activity
N	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
N	0046872	molecular_function	metal ion binding
N	0050262	molecular_function	ribosylnicotinamide kinase activity
N	0061769	molecular_function	ribosylnicotinate kinase activity
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006741	biological_process	NADP+ biosynthetic process
O	0009435	biological_process	NAD+ biosynthetic process
O	0016301	molecular_function	kinase activity
O	0016740	molecular_function	transferase activity
O	0019363	biological_process	pyridine nucleotide biosynthetic process
O	0019674	biological_process	NAD+ metabolic process
O	0034317	molecular_function	nicotinate riboside kinase activity
O	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
O	0046872	molecular_function	metal ion binding
O	0050262	molecular_function	ribosylnicotinamide kinase activity
O	0061769	molecular_function	ribosylnicotinate kinase activity
P	0000166	molecular_function	nucleotide binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006741	biological_process	NADP+ biosynthetic process
P	0009435	biological_process	NAD+ biosynthetic process
P	0016301	molecular_function	kinase activity
P	0016740	molecular_function	transferase activity
P	0019363	biological_process	pyridine nucleotide biosynthetic process
P	0019674	biological_process	NAD+ metabolic process
P	0034317	molecular_function	nicotinate riboside kinase activity
P	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
P	0046872	molecular_function	metal ion binding
P	0050262	molecular_function	ribosylnicotinamide kinase activity
P	0061769	molecular_function	ribosylnicotinate kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2QT0

Chain	Residue	Details
A	ASP36
J	ASP36
K	ASP36
L	ASP36
M	ASP36
N	ASP36
O	ASP36
P	ASP36
B	ASP36
C	ASP36
D	ASP36
E	ASP36
F	ASP36
G	ASP36
H	ASP36
I	ASP36

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17698003, ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2P0E, ECO:0007744\|PDB:2QG6, ECO:0007744\|PDB:2QL6, ECO:0007744\|PDB:2QSY, ECO:0007744\|PDB:2QSZ, ECO:0007744\|PDB:2QT0, ECO:0007744\|PDB:2QT1

Chain	Residue	Details
A	GLY10
J	GLY10
K	GLY10
L	GLY10
M	GLY10
N	GLY10
O	GLY10
P	GLY10
B	GLY10
C	GLY10
D	GLY10
E	GLY10
F	GLY10
G	GLY10
H	GLY10
I	GLY10

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2QSY

Chain	Residue	Details
A	THR17
J	THR17
K	THR17
L	THR17
M	THR17
N	THR17
O	THR17
P	THR17
B	THR17
C	THR17
D	THR17
E	THR17
F	THR17
G	THR17
H	THR17
I	THR17

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2QT0

Chain	Residue	Details
A	ASP36
J	ASP36
K	ASP36
L	ASP36
M	ASP36
N	ASP36
O	ASP36
P	ASP36
B	ASP36
C	ASP36
D	ASP36
E	ASP36
F	ASP36
G	ASP36
H	ASP36
I	ASP36

site_id	SWS_FT_FI5
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17698003, ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2P0E, ECO:0007744\|PDB:2QL6, ECO:0007744\|PDB:2QT0, ECO:0007744\|PDB:2QT1

Chain	Residue	Details
A	TYR55
J	TYR55
K	TYR55
L	TYR55
M	TYR55
N	TYR55
O	TYR55
P	TYR55
B	TYR55
C	TYR55
D	TYR55
E	TYR55
F	TYR55
G	TYR55
H	TYR55
I	TYR55

site_id	SWS_FT_FI6
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2P0E

Chain	Residue	Details
A	ARG128
J	ARG128
K	ARG128
L	ARG128
M	ARG128
N	ARG128
O	ARG128
P	ARG128
B	ARG128
C	ARG128
D	ARG128
E	ARG128
F	ARG128
G	ARG128
H	ARG128
I	ARG128

site_id	SWS_FT_FI7
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2P0E, ECO:0007744\|PDB:2QL6, ECO:0007744\|PDB:2QT0, ECO:0007744\|PDB:2QT1

Chain	Residue	Details
A	ARG129
J	ARG129
K	ARG129
L	ARG129
M	ARG129
N	ARG129
O	ARG129
P	ARG129
B	ARG129
C	ARG129
D	ARG129
E	ARG129
F	ARG129
G	ARG129
H	ARG129
I	ARG129

site_id	SWS_FT_FI8
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17698003, ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2P0E, ECO:0007744\|PDB:2QG6, ECO:0007744\|PDB:2QSY, ECO:0007744\|PDB:2QSZ, ECO:0007744\|PDB:2QT0, ECO:0007744\|PDB:2QT1

Chain	Residue	Details
A	ARG132
J	ARG132
K	ARG132
L	ARG132
M	ARG132
N	ARG132
O	ARG132
P	ARG132
B	ARG132
C	ARG132
D	ARG132
E	ARG132
F	ARG132
G	ARG132
H	ARG132
I	ARG132

site_id	SWS_FT_FI9
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17698003, ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2P0E, ECO:0007744\|PDB:2QL6, ECO:0007744\|PDB:2QT0

Chain	Residue	Details
A	TYR134
J	TYR134
K	TYR134
L	TYR134
M	TYR134
N	TYR134
O	TYR134
P	TYR134
B	TYR134
C	TYR134
D	TYR134
E	TYR134
F	TYR134
G	TYR134
H	TYR134
I	TYR134

site_id	SWS_FT_FI10
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17914902, ECO:0007744\|PDB:2QSY, ECO:0007744\|PDB:2QT0

Chain	Residue	Details
A	LYS172
J	LYS172
K	LYS172
L	LYS172
M	LYS172
N	LYS172
O	LYS172
P	LYS172
B	LYS172
C	LYS172
D	LYS172
E	LYS172
F	LYS172
G	LYS172
H	LYS172
I	LYS172

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)