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2QIV

Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase

Functional Information from GO Data
ChainGOidnamespacecontents
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0008610biological_processlipid biosynthetic process
X0008780molecular_functionacyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
X0009245biological_processlipid A biosynthetic process
X0016740molecular_functiontransferase activity
X0016746molecular_functionacyltransferase activity
X0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
X0042802molecular_functionidentical protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE U21 X 901
ChainResidue
XGLN73
XGLY143
XHIS144
XILE152
XGLN161
XMET170
XASN198
XGLU200
XGLY201
XARG204
XARG205
XASP74
XHOH962
XHOH1063
XHOH1069
XHOH1073
XHOH1084
XHOH1086
XHOH1099
XHOH1121
XHOH1150
XHOH1244
XLEU75
XLYS76
XMET118
XHIS122
XALA124
XHIS125
XASN137

Functional Information from PROSITE/UniProt
site_idPS00101
Number of Residues29
DetailsHEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGanAhIgpfCiVGphVeIGegTvLkshV
ChainResidueDetails
XILE20-VAL48
XILE153-VAL181

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
XGLN73
XHIS125
XHIS144
XGLN161

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1lxa
ChainResidueDetails
XHIS125

site_idMCSA1
Number of Residues3
DetailsM-CSA 69
ChainResidueDetails
XHIS125hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
XASP126electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
XGLY143electrostatic stabiliser, hydrogen bond donor

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PDB entries from 2024-07-31

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