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2QIA

Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine Acyltransferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008610biological_processlipid biosynthetic process
A0008780molecular_functionacyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
A0009245biological_processlipid A biosynthetic process
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
A0042802molecular_functionidentical protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE U20 A 901
ChainResidue
AGLN73
AGLY143
AHIS144
AILE152
AGLN161
APHE162
AMET170
AHIS191
AASN198
AGLU200
AGLY201
AASP74
AARG204
AARG205
AHOH907
AHOH918
AHOH1108
AHOH1125
AHOH1228
AHOH1301
ALEU75
ALYS76
AHIS122
AALA124
AHIS125
AASN137
AALA142

Functional Information from PROSITE/UniProt
site_idPS00101
Number of Residues29
DetailsHEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGanAhIgpfCiVGphVeIGegTvLkshV
ChainResidueDetails
AILE20-VAL48
AILE153-VAL181

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AGLN73
AHIS125
AHIS144
AGLN161

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1lxa
ChainResidueDetails
AHIS125

site_idMCSA1
Number of Residues3
DetailsM-CSA 69
ChainResidueDetails
AHIS125hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
AASP126electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
AGLY143electrostatic stabiliser, hydrogen bond donor

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PDB entries from 2024-09-11

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