2QHS

Structural Basis of Octanoic Acid Recognition by Lipoate-Protein Ligase B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0009249	biological_process	protein lipoylation
A	0016746	molecular_function	acyltransferase activity
A	0033819	molecular_function	lipoyl(octanoyl) transferase activity
A	0036211	biological_process	protein modification process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OCA A 3913

Chain	Residue
A	ARG75
A	HOH4191
A	HOH4266
A	GLY77
A	ASP78
A	LYS136
A	ALA139
A	ILE140
A	GLY141
A	GLY152
A	PHE153

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Functional Information from PROSITE/UniProt

site_id	PS01313
Number of Residues	16
Details	LIPB Lipoate-protein ligase B signature. RGGdvTYHgpGQlVgY

Chain	Residue	Details
A	ARG75-TYR90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000255|HAMAP-Rule:MF_00013

Chain	Residue	Details
A	CYS170

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ARG75
A	ALA139
A	GLY152

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Lowers pKa of active site Cys => ECO:0000255|HAMAP-Rule:MF_00013

Chain	Residue	Details
A	LYS136

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