2QHF
Mycobacterium tuberculosis Chorismate synthase in complex with NCA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004107 | molecular_function | chorismate synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| A | 0016829 | molecular_function | lyase activity |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 502 |
| Chain | Residue |
| A | TRP4 |
| A | ALA250 |
| A | ALA251 |
| A | MET357 |
| A | HOH634 |
| A | HOH831 |
| A | HOH906 |
| A | HOH979 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 503 |
| Chain | Residue |
| A | ARG152 |
| A | ARG156 |
| A | HOH805 |
| A | GLN36 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 504 |
| Chain | Residue |
| A | SER10 |
| A | ARG49 |
| A | LEU133 |
| A | SER137 |
| A | HOH605 |
| A | HOH723 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 505 |
| Chain | Residue |
| A | ARG110 |
| A | ALA335 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 506 |
| Chain | Residue |
| A | ARG40 |
| A | MET50 |
| A | ARG139 |
| A | HOH1042 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 507 |
| Chain | Residue |
| A | GLU9 |
| A | SER10 |
| A | GLY12 |
| A | LEU15 |
| A | GLY78 |
| A | ASN79 |
| A | ARG139 |
| A | HOH1055 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 508 |
| Chain | Residue |
| A | LEU108 |
| A | THR109 |
| A | ARG110 |
| A | ASP117 |
| A | ILE338 |
| A | HOH704 |
| A | HOH724 |
| A | HOH748 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 509 |
| Chain | Residue |
| A | ARG182 |
| A | GLY305 |
| A | GLN306 |
| A | HOH614 |
| A | HOH959 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 510 |
| Chain | Residue |
| A | ARG3 |
| A | HOH856 |
| A | HOH861 |
| A | HOH889 |
| A | HOH1006 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 511 |
| Chain | Residue |
| A | ALA34 |
| A | ARG41 |
| A | ARG54 |
| A | ASP55 |
| A | HOH1076 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 512 |
| Chain | Residue |
| A | GLY114 |
| A | GLN256 |
| A | ALA257 |
| A | GLY300 |
| A | HOH1040 |
| A | HOH1059 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 513 |
| Chain | Residue |
| A | ASP204 |
| A | ALA207 |
| A | HOH722 |
| A | HOH1070 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 601 |
| Chain | Residue |
| A | LEU375 |
| A | ALA376 |
| A | HOH913 |
| A | HOH920 |
| A | HOH989 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 602 |
| Chain | Residue |
| A | PRO180 |
| A | ASN293 |
| A | HOH960 |
| A | HOH1065 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 603 |
| Chain | Residue |
| A | ARG112 |
| A | THR319 |
| A | GLN340 |
| A | ARG341 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NCA A 493 |
| Chain | Residue |
| A | ARG40 |
| A | ARG46 |
| A | ALA138 |
| A | ILE255 |
| A | GLN256 |
| A | MET314 |
| A | ILE317 |
| A | ARG341 |
| A | HOH1041 |
| A | HOH1042 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TRS A 501 |
| Chain | Residue |
| A | HOH1062 |
| A | MET1 |
| A | LEU2 |
| A | GLY21 |
| A | LEU367 |
| A | GLU368 |
| A | GLY371 |
| A | GLY372 |
| A | ASP373 |
| A | HOH882 |
| A | HOH910 |
| A | HOH1022 |
Functional Information from PROSITE/UniProt
| site_id | PS00787 |
| Number of Residues | 16 |
| Details | CHORISMATE_SYNTHASE_1 Chorismate synthase signature 1. GESHGraLVaVVEGmV |
| Chain | Residue | Details |
| A | GLY8-VAL23 |
| site_id | PS00788 |
| Number of Residues | 17 |
| Details | CHORISMATE_SYNTHASE_2 Chorismate synthase signature 2. EraSAReTaarVaaGTV |
| Chain | Residue | Details |
| A | GLU134-VAL150 |
| site_id | PS00789 |
| Number of Residues | 17 |
| Details | CHORISMATE_SYNTHASE_3 Chorismate synthase signature 3. RSDVCavpaAgVVvETM |
| Chain | Residue | Details |
| A | ARG341-MET357 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00300","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"PDB data bank","title":"Mycobacterium tuberculosis chorismate synthase in complex with NCA and FMN.","authors":["Bruning M.","Bourenkov G.P.","Strizhov N.I.","Bartunik H.D."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00300","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
