2QG6
Crystal structure of human nicotinamide riboside kinase (NRK1) in complex with nicotinamide mononucleotide (NMN)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009435 | biological_process | NAD biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0019674 | biological_process | NAD metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050262 | molecular_function | ribosylnicotinamide kinase activity |
| A | 0061769 | molecular_function | ribosylnicotinate kinase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2QT0 |
| Chain | Residue | Details |
| A | ASP36 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17698003, ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2P0E, ECO:0007744|PDB:2QG6, ECO:0007744|PDB:2QL6, ECO:0007744|PDB:2QSY, ECO:0007744|PDB:2QSZ, ECO:0007744|PDB:2QT0, ECO:0007744|PDB:2QT1 |
| Chain | Residue | Details |
| A | GLY10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2QSY |
| Chain | Residue | Details |
| A | THR17 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2QT0 |
| Chain | Residue | Details |
| A | ASP36 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17698003, ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2P0E, ECO:0007744|PDB:2QL6, ECO:0007744|PDB:2QT0, ECO:0007744|PDB:2QT1 |
| Chain | Residue | Details |
| A | TYR55 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2P0E |
| Chain | Residue | Details |
| A | ARG128 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2P0E, ECO:0007744|PDB:2QL6, ECO:0007744|PDB:2QT0, ECO:0007744|PDB:2QT1 |
| Chain | Residue | Details |
| A | ARG129 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17698003, ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2P0E, ECO:0007744|PDB:2QG6, ECO:0007744|PDB:2QSY, ECO:0007744|PDB:2QSZ, ECO:0007744|PDB:2QT0, ECO:0007744|PDB:2QT1 |
| Chain | Residue | Details |
| A | ARG132 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17698003, ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2P0E, ECO:0007744|PDB:2QL6, ECO:0007744|PDB:2QT0 |
| Chain | Residue | Details |
| A | TYR134 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17914902, ECO:0007744|PDB:2QSY, ECO:0007744|PDB:2QT0 |
| Chain | Residue | Details |
| A | LYS172 |
