2QAG

Crystal structure of human septin trimer 2/6/7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0002036	biological_process	regulation of L-glutamate import across plasma membrane
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0005930	cellular_component	axoneme
A	0005938	cellular_component	cell cortex
A	0005940	cellular_component	septin ring
A	0007224	biological_process	smoothened signaling pathway
A	0007283	biological_process	spermatogenesis
A	0008104	biological_process	protein localization
A	0009986	cellular_component	cell surface
A	0015629	cellular_component	actin cytoskeleton
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0030154	biological_process	cell differentiation
A	0030234	molecular_function	enzyme regulator activity
A	0030496	cellular_component	midbody
A	0031105	cellular_component	septin complex
A	0031514	cellular_component	motile cilium
A	0032153	cellular_component	cell division site
A	0032154	cellular_component	cleavage furrow
A	0032391	cellular_component	photoreceptor connecting cilium
A	0032880	biological_process	regulation of protein localization
A	0035869	cellular_component	ciliary transition zone
A	0042995	cellular_component	cell projection
A	0045171	cellular_component	intercellular bridge
A	0045202	cellular_component	synapse
A	0045296	molecular_function	cadherin binding
A	0051301	biological_process	cell division
A	0060090	molecular_function	molecular adaptor activity
A	0060170	cellular_component	ciliary membrane
A	0060271	biological_process	cilium assembly
A	0061640	biological_process	cytoskeleton-dependent cytokinesis
A	0070062	cellular_component	extracellular exosome
A	0097227	cellular_component	sperm annulus
A	0097730	cellular_component	non-motile cilium
B	0000166	molecular_function	nucleotide binding
B	0000281	biological_process	mitotic cytokinesis
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005819	cellular_component	spindle
B	0005856	cellular_component	cytoskeleton
B	0005929	cellular_component	cilium
B	0005940	cellular_component	septin ring
B	0007283	biological_process	spermatogenesis
B	0008021	cellular_component	synaptic vesicle
B	0008104	biological_process	protein localization
B	0015630	cellular_component	microtubule cytoskeleton
B	0030154	biological_process	cell differentiation
B	0030496	cellular_component	midbody
B	0031105	cellular_component	septin complex
B	0031514	cellular_component	motile cilium
B	0032153	cellular_component	cell division site
B	0032154	cellular_component	cleavage furrow
B	0032173	cellular_component	septin collar
B	0042995	cellular_component	cell projection
B	0043679	cellular_component	axon terminus
B	0051301	biological_process	cell division
B	0060090	molecular_function	molecular adaptor activity
B	0061640	biological_process	cytoskeleton-dependent cytokinesis
B	0097227	cellular_component	sperm annulus
B	0098793	cellular_component	presynapse
C	0000166	molecular_function	nucleotide binding
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0001725	cellular_component	stress fiber
C	0003924	molecular_function	GTPase activity
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005929	cellular_component	cilium
C	0005930	cellular_component	axoneme
C	0005940	cellular_component	septin ring
C	0007283	biological_process	spermatogenesis
C	0008104	biological_process	protein localization
C	0015630	cellular_component	microtubule cytoskeleton
C	0016324	cellular_component	apical plasma membrane
C	0016476	biological_process	regulation of embryonic cell shape
C	0030154	biological_process	cell differentiation
C	0030496	cellular_component	midbody
C	0031105	cellular_component	septin complex
C	0031514	cellular_component	motile cilium
C	0032153	cellular_component	cell division site
C	0032154	cellular_component	cleavage furrow
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0045296	molecular_function	cadherin binding
C	0051301	biological_process	cell division
C	0060090	molecular_function	molecular adaptor activity
C	0060271	biological_process	cilium assembly
C	0061640	biological_process	cytoskeleton-dependent cytokinesis
C	0070062	cellular_component	extracellular exosome
C	0097227	cellular_component	sperm annulus
C	0097730	cellular_component	non-motile cilium
C	1902857	biological_process	positive regulation of non-motile cilium assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GDP A 362

Chain	Residue
A	SER46
A	VAL240
A	TYR258
B	ALA188
B	GLU193
A	GLY47
A	LEU48
A	GLY49
A	LYS50
A	SER51
A	THR52
A	LYS183
A	ASP185

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GTP B 428

Chain	Residue
A	THR186
A	GLU191
A	ARG194
B	THR51
B	GLY52
B	GLY54
B	LYS55
B	SER56
B	THR57
B	LYS185
B	ALA186
B	ASP187

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GDP C 419

Chain	Residue
C	SER40
C	GLY41
C	LEU42
C	GLY43
C	LYS44
C	SER45
C	THR46
C	GLU60
C	LYS176
C	ASP178
C	THR179
C	GLY231
C	TYR248

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Important for dimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17637674","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O55131","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---