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2QAG

Crystal structure of human septin trimer 2/6/7

Functional Information from GO Data
ChainGOidnamespacecontents
A0000775cellular_componentchromosome, centromeric region
A0000776cellular_componentkinetochore
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005819cellular_componentspindle
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005938cellular_componentcell cortex
A0005940cellular_componentseptin ring
A0007224biological_processsmoothened signaling pathway
A0007283biological_processspermatogenesis
A0008021cellular_componentsynaptic vesicle
A0008104biological_processprotein localization
A0015629cellular_componentactin cytoskeleton
A0015630cellular_componentmicrotubule cytoskeleton
A0017157biological_processregulation of exocytosis
A0030154biological_processcell differentiation
A0030496cellular_componentmidbody
A0031105cellular_componentseptin complex
A0031514cellular_componentmotile cilium
A0032153cellular_componentcell division site
A0032154cellular_componentcleavage furrow
A0032391cellular_componentphotoreceptor connecting cilium
A0045171cellular_componentintercellular bridge
A0045296molecular_functioncadherin binding
A0051301biological_processcell division
A0060090molecular_functionmolecular adaptor activity
A0060170cellular_componentciliary membrane
A0060271biological_processcilium assembly
A0061640biological_processcytoskeleton-dependent cytokinesis
A0070062cellular_componentextracellular exosome
A0097227cellular_componentsperm annulus
A0097730cellular_componentnon-motile cilium
B0000281biological_processmitotic cytokinesis
B0000775cellular_componentchromosome, centromeric region
B0000776cellular_componentkinetochore
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0005856cellular_componentcytoskeleton
B0005940cellular_componentseptin ring
B0007283biological_processspermatogenesis
B0008021cellular_componentsynaptic vesicle
B0008104biological_processprotein localization
B0015630cellular_componentmicrotubule cytoskeleton
B0030154biological_processcell differentiation
B0030496cellular_componentmidbody
B0031105cellular_componentseptin complex
B0031514cellular_componentmotile cilium
B0032153cellular_componentcell division site
B0032154cellular_componentcleavage furrow
B0032173cellular_componentseptin collar
B0043679cellular_componentaxon terminus
B0051301biological_processcell division
B0060090molecular_functionmolecular adaptor activity
B0060271biological_processcilium assembly
B0061640biological_processcytoskeleton-dependent cytokinesis
B0097227cellular_componentsperm annulus
B0098793cellular_componentpresynapse
C0000775cellular_componentchromosome, centromeric region
C0000776cellular_componentkinetochore
C0001725cellular_componentstress fiber
C0003924molecular_functionGTPase activity
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005930cellular_componentaxoneme
C0005940cellular_componentseptin ring
C0007283biological_processspermatogenesis
C0008104biological_processprotein localization
C0015630cellular_componentmicrotubule cytoskeleton
C0016324cellular_componentapical plasma membrane
C0016476biological_processregulation of embryonic cell shape
C0030154biological_processcell differentiation
C0030496cellular_componentmidbody
C0031105cellular_componentseptin complex
C0031514cellular_componentmotile cilium
C0032153cellular_componentcell division site
C0032154cellular_componentcleavage furrow
C0042802molecular_functionidentical protein binding
C0045296molecular_functioncadherin binding
C0051301biological_processcell division
C0060090molecular_functionmolecular adaptor activity
C0060271biological_processcilium assembly
C0061640biological_processcytoskeleton-dependent cytokinesis
C0070062cellular_componentextracellular exosome
C0097227cellular_componentsperm annulus
C0097730cellular_componentnon-motile cilium
C1902857biological_processpositive regulation of non-motile cilium assembly
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GDP A 362
ChainResidue
ASER46
AVAL240
ATYR258
BALA188
BGLU193
AGLY47
ALEU48
AGLY49
ALYS50
ASER51
ATHR52
ALYS183
AASP185

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GTP B 428
ChainResidue
ATHR186
AGLU191
AARG194
BTHR51
BGLY52
BGLY54
BLYS55
BSER56
BTHR57
BLYS185
BALA186
BASP187

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GDP C 419
ChainResidue
CSER40
CGLY41
CLEU42
CGLY43
CLYS44
CSER45
CTHR46
CGLU60
CLYS176
CASP178
CTHR179
CGLY231
CTYR248

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING:
ChainResidueDetails
CGLY38
BLYS185
AGLY241
AARG256

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CTHR71
CGLY97
CLYS176
CGLY231
CARG246

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O55131
ChainResidueDetails
CTYR11

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O55131
ChainResidueDetails
CSER58
BSER416

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CTHR209

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER315

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O55131
ChainResidueDetails
CLYS354

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CSER405

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
CTHR407

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PDB entries from 2024-07-24

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