2QAE
Crystal Structure Analysis of Trypanosoma cruzi Lipoamide dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD A 480 |
| Chain | Residue |
| A | ILE8 |
| A | THR40 |
| A | CYS41 |
| A | GLY45 |
| A | CYS46 |
| A | LYS50 |
| A | GLY113 |
| A | GLU114 |
| A | GLY115 |
| A | THR144 |
| A | GLY145 |
| A | GLY9 |
| A | SER164 |
| A | ILE185 |
| A | ARG274 |
| A | PHE277 |
| A | GLY313 |
| A | ASP314 |
| A | MET321 |
| A | LEU322 |
| A | ALA323 |
| A | HIS324 |
| A | GLY11 |
| A | HOH481 |
| A | HOH490 |
| A | HOH497 |
| B | HIS447 |
| B | PRO448 |
| A | PRO12 |
| A | GLY13 |
| A | GLU32 |
| A | LYS33 |
| A | ARG34 |
| A | GLY39 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD B 480 |
| Chain | Residue |
| A | HIS447 |
| A | PRO448 |
| B | ILE8 |
| B | GLY9 |
| B | GLY11 |
| B | PRO12 |
| B | GLY13 |
| B | GLU32 |
| B | LYS33 |
| B | ARG34 |
| B | GLY39 |
| B | THR40 |
| B | CYS41 |
| B | GLY45 |
| B | CYS46 |
| B | LYS50 |
| B | GLY113 |
| B | GLU114 |
| B | GLY115 |
| B | THR144 |
| B | GLY145 |
| B | SER164 |
| B | ILE185 |
| B | ARG274 |
| B | PHE277 |
| B | GLY313 |
| B | ASP314 |
| B | MET321 |
| B | LEU322 |
| B | ALA323 |
| B | HIS324 |
| B | HOH485 |
| B | HOH493 |
| B | HOH498 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP |
| Chain | Residue | Details |
| A | GLY38-PRO48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS46 | |
| A | CYS41 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | CYS46 | |
| B | CYS41 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU452 | |
| A | HIS447 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | GLU452 | |
| B | HIS447 |
