Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 912 |
| Chain | Residue |
| A | THR163 |
| A | ARG182 |
| A | THR183 |
| A | ASN184 |
| A | THR225 |
| A | HOH1078 |
| A | HOH1136 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 913 |
| Chain | Residue |
| A | EDO921 |
| A | HOH1025 |
| A | HOH1230 |
| A | ARG139 |
| A | THR157 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 941 |
| Chain | Residue |
| A | GLY48 |
| A | EDO923 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 945 |
| Chain | Residue |
| A | ARG41 |
| A | ACY931 |
| A | HOH1203 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 950 |
| Chain | Residue |
| A | LYS115 |
| A | HOH1132 |
| A | HOH1213 |
| A | HOH1214 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 957 |
| Chain | Residue |
| A | THR207 |
| A | ACY933 |
| A | HOH1238 |
| A | HOH1239 |
| B | ASN101 |
| B | HOH1186 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 911 |
| Chain | Residue |
| B | THR163 |
| B | ARG182 |
| B | THR183 |
| B | ASN184 |
| B | THR225 |
| B | HOH1072 |
| B | HOH1081 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 914 |
| Chain | Residue |
| A | HOH978 |
| B | ASN170 |
| B | GLY172 |
| B | GLY173 |
| B | HOH959 |
| B | HOH1181 |
| B | HOH1195 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 915 |
| Chain | Residue |
| A | GLY174 |
| A | HOH975 |
| B | ARG139 |
| B | GLY156 |
| B | THR157 |
| B | GOL904 |
| B | HOH1116 |
| B | HOH1125 |
| B | HOH1197 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 942 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 943 |
| Chain | Residue |
| B | ARG41 |
| B | HOH1050 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 944 |
| Chain | Residue |
| B | ARG208 |
| B | HOH1006 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 946 |
| Chain | Residue |
| A | THR39 |
| B | THR64 |
| B | THR65 |
| B | HOH1170 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 952 |
| Chain | Residue |
| B | HIS158 |
| B | CYS220 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 954 |
| Chain | Residue |
| B | SER89 |
| B | TYR237 |
| site_id | BC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TYR A 1 |
| Chain | Residue |
| A | HIS57 |
| A | ALA192 |
| A | GLU192 |
| A | PRO192 |
| A | GLY193 |
| A | SER195 |
| A | GLY216 |
| A | SER217 |
| A | GLY218 |
| A | GOL901 |
| A | HOH1046 |
| A | HOH1146 |
| A | HOH1165 |
| A | HOH1208 |
| A | HOH1232 |
| A | HOH1235 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LEU A 2 |
| Chain | Residue |
| A | HIS57 |
| A | GLU192 |
| A | PRO192 |
| A | GLY193 |
| A | SER195 |
| A | THR213 |
| A | SER214 |
| A | GLY215 |
| A | GOL901 |
| A | HOH1208 |
| A | HOH1232 |
| A | HOH1235 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 921 |
| Chain | Residue |
| A | HOH997 |
| A | GLY19 |
| A | ASP29 |
| A | ARG139 |
| A | GLY140 |
| A | SER141 |
| A | GLY156 |
| A | SO4913 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 922 |
| Chain | Residue |
| A | SER33 |
| A | THR39 |
| A | GLY40 |
| A | CYS42 |
| A | CYS58 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 923 |
| Chain | Residue |
| A | ARG48 |
| A | THR125 |
| A | SER240 |
| A | VAL241 |
| A | TYR242 |
| A | CL941 |
| site_id | CC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EPE A 961 |
| Chain | Residue |
| A | THR87 |
| A | ARG107 |
| A | HOH979 |
| B | SER126 |
| B | ALA127 |
| B | LEU235 |
| B | SER240 |
| B | VAL241 |
| B | ACY932 |
| B | HOH966 |
| B | HOH1087 |
| site_id | CC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE TYR B 1 |
| Chain | Residue |
| B | HIS57 |
| B | ALA192 |
| B | GLU192 |
| B | PRO192 |
| B | GLY193 |
| B | SER195 |
| B | SER214 |
| B | GLY215 |
| B | GLY216 |
| B | SER217 |
| B | GLY218 |
| B | GOL902 |
| B | HOH1013 |
| B | HOH1176 |
| B | HOH1177 |
| B | HOH1178 |
| B | HOH1192 |
| site_id | CC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LEU B 2 |
| Chain | Residue |
| B | HIS57 |
| B | GLU192 |
| B | PRO192 |
| B | GLY193 |
| B | SER195 |
| B | THR213 |
| B | SER214 |
| B | GLY215 |
| B | GOL902 |
| B | HOH1178 |
| B | HOH1192 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 924 |
| Chain | Residue |
| B | ALA135 |
| B | VAL136 |
| B | THR137 |
| B | GLY202 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 901 |
| Chain | Residue |
| A | TYR1 |
| A | LEU2 |
| A | HIS57 |
| A | TYR171 |
| A | SER214 |
| A | GLY215 |
| A | HOH1194 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY A 931 |
| Chain | Residue |
| A | SER79 |
| A | ARG81 |
| A | CL945 |
| A | HOH1090 |
| B | HOH1009 |
| site_id | CC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ACY A 933 |
| Chain | Residue |
| A | SER48 |
| A | GLN122 |
| A | GLY202 |
| A | THR207 |
| A | CL957 |
| A | HOH1105 |
| A | HOH1113 |
| B | ASN101 |
| B | GLU233 |
| B | HOH1004 |
| B | HOH1145 |
| site_id | DC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 902 |
| Chain | Residue |
| B | TYR1 |
| B | LEU2 |
| B | TYR171 |
| B | SER214 |
| B | GLY215 |
| B | HOH1144 |
| B | HOH1163 |
| B | HOH1178 |
| site_id | DC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 903 |
| Chain | Residue |
| A | SER48 |
| A | GLY238 |
| A | HOH970 |
| A | HOH983 |
| B | ASN166 |
| B | GLY179 |
| B | MET180 |
| B | PRO230 |
| B | HOH960 |
| B | HOH1030 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 904 |
| Chain | Residue |
| A | ASN100 |
| A | GLY174 |
| A | TYR178 |
| A | HOH1218 |
| B | GLY156 |
| B | THR157 |
| B | SO4915 |
| B | HOH1101 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 932 |
| Chain | Residue |
| A | EPE961 |
| B | ARG48 |
| B | SER240 |
| B | HOH1070 |
| B | HOH1127 |
| B | HOH1175 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAGHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAepGDSGGPLY |
| Chain | Residue | Details |
| A | CYS191-TYR200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
| B | HIS57 | |
| B | ASP102 | |
| B | SER195 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| A | SER214 | |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| B | SER214 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 608 |
| Chain | Residue | Details |
| A | HIS57 | proton acceptor, proton donor |
| A | ASP102 | electrostatic stabiliser |
| A | GLY193 | electrostatic stabiliser |
| A | SER195 | nucleofuge, nucleophile, proton acceptor, proton donor |
| A | SER214 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 608 |
| Chain | Residue | Details |
| B | HIS57 | proton acceptor, proton donor |
| B | ASP102 | electrostatic stabiliser |
| B | GLY193 | electrostatic stabiliser |
| B | SER195 | nucleofuge, nucleophile, proton acceptor, proton donor |
| B | SER214 | electrostatic stabiliser |
