2Q9P
Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000298 | molecular_function | endopolyphosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008486 | molecular_function | diphosphoinositol-polyphosphate diphosphatase activity |
| A | 0015961 | biological_process | diadenosine polyphosphate catabolic process |
| A | 0016462 | molecular_function | pyrophosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0034431 | molecular_function | bis(5'-adenosyl)-hexaphosphatase activity |
| A | 0034432 | molecular_function | bis(5'-adenosyl)-pentaphosphatase activity |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052840 | molecular_function | inositol diphosphate tetrakisphosphate diphosphatase activity |
| A | 0052842 | molecular_function | inositol diphosphate pentakisphosphate diphosphatase activity |
| A | 0052845 | molecular_function | inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
| A | 0052848 | molecular_function | inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| A | 0071543 | biological_process | diphosphoinositol polyphosphate metabolic process |
| A | 0071544 | biological_process | diphosphoinositol polyphosphate catabolic process |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0110154 | biological_process | RNA decapping |
| A | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| A | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| A | 1901907 | biological_process | diadenosine pentaphosphate catabolic process |
| A | 1901909 | biological_process | diadenosine hexaphosphate catabolic process |
| A | 1901911 | biological_process | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | GLU66 |
| A | F410 |
| A | GLU70 |
| A | IHP201 |
| A | MG302 |
| A | MG303 |
| A | MG304 |
| A | F403 |
| A | F405 |
| A | F409 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MG A 302 |
| Chain | Residue |
| A | GLY50 |
| A | GLY51 |
| A | GLU70 |
| A | IHP201 |
| A | MG301 |
| A | MG303 |
| A | F402 |
| A | F403 |
| A | F410 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MG A 303 |
| Chain | Residue |
| A | IHP201 |
| A | MG301 |
| A | MG302 |
| A | MG304 |
| A | F403 |
| A | F404 |
| A | F406 |
| A | F409 |
| A | F410 |
| A | HOH836 |
| A | HOH837 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG A 304 |
| Chain | Residue |
| A | GLU66 |
| A | MG301 |
| A | MG303 |
| A | F404 |
| A | F406 |
| A | F407 |
| A | F408 |
| A | F409 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 401 |
| Chain | Residue |
| A | SER28 |
| A | SER30 |
| A | GLU31 |
| A | GLU32 |
| A | GLU33 |
| A | HOH846 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE F A 402 |
| Chain | Residue |
| A | ILE47 |
| A | GLY50 |
| A | GLU70 |
| A | IHP201 |
| A | MG302 |
| A | HOH566 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE F A 403 |
| Chain | Residue |
| A | GLY50 |
| A | GLY51 |
| A | GLU66 |
| A | GLU70 |
| A | IHP201 |
| A | MG301 |
| A | MG302 |
| A | MG303 |
| A | F404 |
| A | F409 |
| A | F410 |
| A | HOH837 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE F A 404 |
| Chain | Residue |
| A | GLY51 |
| A | GLY52 |
| A | GLU66 |
| A | IHP201 |
| A | MG303 |
| A | MG304 |
| A | F403 |
| A | F406 |
| A | F407 |
| A | F409 |
| A | HOH821 |
| A | HOH836 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE F A 405 |
| Chain | Residue |
| A | GLU66 |
| A | GLU69 |
| A | GLU70 |
| A | MG301 |
| A | F409 |
| A | F410 |
| A | HOH725 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE F A 406 |
| Chain | Residue |
| A | MG303 |
| A | MG304 |
| A | F404 |
| A | F407 |
| A | F408 |
| A | F409 |
| A | HOH836 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F A 407 |
| Chain | Residue |
| A | GLY52 |
| A | ARG65 |
| A | GLU66 |
| A | MG304 |
| A | F404 |
| A | F406 |
| A | F408 |
| A | HOH637 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F A 408 |
| Chain | Residue |
| A | MG304 |
| A | F406 |
| A | F407 |
| A | F409 |
| A | HOH824 |
| A | ARG65 |
| A | GLU66 |
| A | GLU69 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE F A 409 |
| Chain | Residue |
| A | GLU66 |
| A | MG301 |
| A | MG303 |
| A | MG304 |
| A | F403 |
| A | F404 |
| A | F405 |
| A | F406 |
| A | F408 |
| A | F410 |
| A | HOH612 |
| site_id | BC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE F A 410 |
| Chain | Residue |
| A | GLU70 |
| A | ARG115 |
| A | IHP201 |
| A | MG301 |
| A | MG302 |
| A | MG303 |
| A | F403 |
| A | F405 |
| A | F409 |
| A | HOH589 |
| A | HOH837 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE F A 411 |
| Chain | Residue |
| A | ASN86 |
| A | GLN136 |
| site_id | BC7 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE IHP A 201 |
| Chain | Residue |
| A | ARG10 |
| A | LYS18 |
| A | ARG20 |
| A | SER39 |
| A | SER40 |
| A | ARG41 |
| A | ILE47 |
| A | GLY50 |
| A | GLY51 |
| A | GLY52 |
| A | GLU70 |
| A | ARG89 |
| A | HIS91 |
| A | ARG115 |
| A | LYS133 |
| A | MG301 |
| A | MG302 |
| A | MG303 |
| A | F402 |
| A | F403 |
| A | F404 |
| A | F410 |
| A | HOH602 |
| A | HOH606 |
| A | HOH738 |
| A | HOH803 |
| A | HOH821 |
| A | HOH836 |
| A | HOH837 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG |
| Chain | Residue | Details |
| A | GLY51-GLY72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305 |
| Chain | Residue | Details |
| A | GLU69 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2FVV, ECO:0007744|PDB:2Q9P |
| Chain | Residue | Details |
| A | ARG10 | |
| A | LYS18 | |
| A | SER39 | |
| A | ARG89 | |
| A | LYS133 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2Q9P |
| Chain | Residue | Details |
| A | GLY50 | |
| A | GLU66 | |
| A | GLU70 | |
| A | ARG115 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 |
