2Q9P

Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000298	molecular_function	endopolyphosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007267	biological_process	cell-cell signaling
A	0008270	molecular_function	zinc ion binding
A	0008486	molecular_function	diphosphoinositol-polyphosphate diphosphatase activity
A	0015961	biological_process	diadenosine polyphosphate catabolic process
A	0016462	molecular_function	pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0034431	molecular_function	bis(5'-adenosyl)-hexaphosphatase activity
A	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0052840	molecular_function	inositol diphosphate tetrakisphosphate diphosphatase activity
A	0052842	molecular_function	inositol diphosphate pentakisphosphate diphosphatase activity
A	0052845	molecular_function	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
A	0052848	molecular_function	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
A	0071543	biological_process	diphosphoinositol polyphosphate metabolic process
A	0071544	biological_process	diphosphoinositol polyphosphate catabolic process
A	0098978	cellular_component	glutamatergic synapse
A	0110154	biological_process	RNA decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
A	1901907	biological_process	diadenosine pentaphosphate catabolic process
A	1901909	biological_process	diadenosine hexaphosphate catabolic process
A	1901911	biological_process	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MG A 301

Chain	Residue
A	GLU66
A	F410
A	GLU70
A	IHP201
A	MG302
A	MG303
A	MG304
A	F403
A	F405
A	F409

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	GLY50
A	GLY51
A	GLU70
A	IHP201
A	MG301
A	MG303
A	F402
A	F403
A	F410

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MG A 303

Chain	Residue
A	IHP201
A	MG301
A	MG302
A	MG304
A	F403
A	F404
A	F406
A	F409
A	F410
A	HOH836
A	HOH837

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG A 304

Chain	Residue
A	GLU66
A	MG301
A	MG303
A	F404
A	F406
A	F407
A	F408
A	F409

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 401

Chain	Residue
A	SER28
A	SER30
A	GLU31
A	GLU32
A	GLU33
A	HOH846

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE F A 402

Chain	Residue
A	ILE47
A	GLY50
A	GLU70
A	IHP201
A	MG302
A	HOH566

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE F A 403

Chain	Residue
A	GLY50
A	GLY51
A	GLU66
A	GLU70
A	IHP201
A	MG301
A	MG302
A	MG303
A	F404
A	F409
A	F410
A	HOH837

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE F A 404

Chain	Residue
A	GLY51
A	GLY52
A	GLU66
A	IHP201
A	MG303
A	MG304
A	F403
A	F406
A	F407
A	F409
A	HOH821
A	HOH836

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE F A 405

Chain	Residue
A	GLU66
A	GLU69
A	GLU70
A	MG301
A	F409
A	F410
A	HOH725

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE F A 406

Chain	Residue
A	MG303
A	MG304
A	F404
A	F407
A	F408
A	F409
A	HOH836

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE F A 407

Chain	Residue
A	GLY52
A	ARG65
A	GLU66
A	MG304
A	F404
A	F406
A	F408
A	HOH637

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE F A 408

Chain	Residue
A	MG304
A	F406
A	F407
A	F409
A	HOH824
A	ARG65
A	GLU66
A	GLU69

---

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE F A 409

Chain	Residue
A	GLU66
A	MG301
A	MG303
A	MG304
A	F403
A	F404
A	F405
A	F406
A	F408
A	F410
A	HOH612

---

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE F A 410

Chain	Residue
A	GLU70
A	ARG115
A	IHP201
A	MG301
A	MG302
A	MG303
A	F403
A	F405
A	F409
A	HOH589
A	HOH837

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE F A 411

Chain	Residue
A	ASN86
A	GLN136

---

site_id	BC7
Number of Residues	29
Details	BINDING SITE FOR RESIDUE IHP A 201

Chain	Residue
A	ARG10
A	LYS18
A	ARG20
A	SER39
A	SER40
A	ARG41
A	ILE47
A	GLY50
A	GLY51
A	GLY52
A	GLU70
A	ARG89
A	HIS91
A	ARG115
A	LYS133
A	MG301
A	MG302
A	MG303
A	F402
A	F403
A	F404
A	F410
A	HOH602
A	HOH606
A	HOH738
A	HOH803
A	HOH821
A	HOH836
A	HOH837

---

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG

Chain	Residue	Details
A	GLY51-GLY72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---