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2Q7Z

Solution Structure of the 30 SCR domains of human Complement Receptor 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001848molecular_functioncomplement binding
A0001851molecular_functioncomplement component C3b binding
A0001855molecular_functioncomplement component C4b binding
A0001861molecular_functioncomplement component C4b receptor activity
A0001970biological_processpositive regulation of activation of membrane attack complex
A0001971biological_processnegative regulation of activation of membrane attack complex
A0002376biological_processimmune system process
A0002430biological_processcomplement receptor mediated signaling pathway
A0002435biological_processimmune complex clearance by erythrocytes
A0002456biological_processT cell mediated immunity
A0002638biological_processnegative regulation of immunoglobulin production
A0004875molecular_functioncomplement receptor activity
A0004877molecular_functioncomplement component C3b receptor activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0007009biological_processplasma membrane organization
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0030449biological_processregulation of complement activation
A0030667cellular_componentsecretory granule membrane
A0032689biological_processnegative regulation of type II interferon production
A0032703biological_processnegative regulation of interleukin-2 production
A0042130biological_processnegative regulation of T cell proliferation
A0044853cellular_componentplasma membrane raft
A0045087biological_processinnate immune response
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045916biological_processnegative regulation of complement activation
A0045957biological_processnegative regulation of complement activation, alternative pathway
A0045959biological_processnegative regulation of complement activation, classical pathway
A0046718biological_processsymbiont entry into host cell
A0070062cellular_componentextracellular exosome
A0101003cellular_componentficolin-1-rich granule membrane
A1900004biological_processnegative regulation of serine-type endopeptidase activity
A1900005biological_processpositive regulation of serine-type endopeptidase activity
A1900099biological_processnegative regulation of plasma cell differentiation
A1903659biological_processregulation of complement-dependent cytotoxicity
A1903660biological_processnegative regulation of complement-dependent cytotoxicity
A1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1929
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN1-ASP1930

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000255
ChainResidueDetails
AGLN1

site_idSWS_FT_FI3
Number of Residues20
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN15
AASN918
AASN987
AASN1111
AASN1269
AASN1440
AASN1463
AASN1493
AASN1499
AASN1564
AASN1722
AASN211
AASN1867
AASN369
AASN406
AASN468
AASN537
AASN661
AASN819
AASN856

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PDB entries from 2025-06-18

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