2Q5E
Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| B | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| C | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| C | 0016791 | molecular_function | phosphatase activity |
| D | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| D | 0016791 | molecular_function | phosphatase activity |
| E | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| E | 0016791 | molecular_function | phosphatase activity |
| F | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| F | 0016791 | molecular_function | phosphatase activity |
| G | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| G | 0016791 | molecular_function | phosphatase activity |
| H | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| H | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1 |
| Chain | Residue |
| A | ASP107 |
| A | ASP109 |
| A | ASN218 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1 |
| Chain | Residue |
| B | ASP107 |
| B | ASP109 |
| B | ASN218 |
| B | SER219 |
| B | HOH275 |
| B | HOH280 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1 |
| Chain | Residue |
| C | ASP107 |
| C | ASP109 |
| C | ASN218 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1 |
| Chain | Residue |
| D | ASP107 |
| D | ASP109 |
| D | THR111 |
| D | ASN218 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG E 1 |
| Chain | Residue |
| E | ASP107 |
| E | ASP109 |
| E | THR111 |
| E | ASN218 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG F 1 |
| Chain | Residue |
| F | ASP107 |
| F | ASP109 |
| F | ASP217 |
| F | ASN218 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG G 1 |
| Chain | Residue |
| G | ASP107 |
| G | ASP109 |
| G | THR111 |
| G | ASP217 |
| G | ASN218 |
| G | SER219 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG H 1 |
| Chain | Residue |
| H | ASP107 |
| H | ASP109 |
| H | ASN218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP107 | |
| B | ASP107 | |
| C | ASP107 | |
| D | ASP107 | |
| E | ASP107 | |
| F | ASP107 | |
| G | ASP107 | |
| H | ASP107 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP109 | |
| B | ASP109 | |
| C | ASP109 | |
| D | ASP109 | |
| E | ASP109 | |
| F | ASP109 | |
| G | ASP109 | |
| H | ASP109 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18058037 |
| Chain | Residue | Details |
| A | ASP107 | |
| D | ASP107 | |
| D | ASP109 | |
| D | ASN218 | |
| E | ASP107 | |
| E | ASP109 | |
| E | ASN218 | |
| F | ASP107 | |
| F | ASP109 | |
| F | ASN218 | |
| G | ASP107 | |
| A | ASP109 | |
| G | ASP109 | |
| G | ASN218 | |
| H | ASP107 | |
| H | ASP109 | |
| H | ASN218 | |
| A | ASN218 | |
| B | ASP107 | |
| B | ASP109 | |
| B | ASN218 | |
| C | ASP107 | |
| C | ASP109 | |
| C | ASN218 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | THR163 | |
| E | LYS201 | |
| F | THR163 | |
| F | LYS201 | |
| G | THR163 | |
| G | LYS201 | |
| H | THR163 | |
| H | LYS201 | |
| A | LYS201 | |
| B | THR163 | |
| B | LYS201 | |
| C | THR163 | |
| C | LYS201 | |
| D | THR163 | |
| D | LYS201 | |
| E | THR163 |
