2Q58
Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with zoledronate
Replaces: 2HERFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3 |
| Chain | Residue |
| A | ZOL1 |
| A | MG4 |
| A | ASP1115 |
| A | ASP1119 |
| A | HOH8002 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 4 |
| Chain | Residue |
| A | HOH8001 |
| A | ZOL1 |
| A | MG3 |
| A | ASP1115 |
| A | ASP1119 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 5 |
| Chain | Residue |
| A | ZOL1 |
| A | ASN1254 |
| A | HOH8006 |
| A | HOH8007 |
| A | HOH8008 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 6 |
| Chain | Residue |
| B | ZOL2 |
| B | ASP2115 |
| B | ASP2119 |
| B | HOH8003 |
| B | HOH8004 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 7 |
| Chain | Residue |
| B | ZOL2 |
| B | ASP2115 |
| B | ASP2119 |
| B | ASP2187 |
| B | LYS2273 |
| B | HOH8005 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 8 |
| Chain | Residue |
| B | ZOL2 |
| B | ASN2254 |
| B | HOH8009 |
| B | HOH8010 |
| B | HOH8011 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ZOL A 1 |
| Chain | Residue |
| A | MG3 |
| A | MG4 |
| A | MG5 |
| A | LEU1112 |
| A | ASP1115 |
| A | ASP1119 |
| A | ARG1124 |
| A | GLN1184 |
| A | LYS1210 |
| A | THR1211 |
| A | GLN1251 |
| A | ASN1254 |
| A | HOH8007 |
| A | HOH8008 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ZOL B 2 |
| Chain | Residue |
| B | MG6 |
| B | MG7 |
| B | MG8 |
| B | ASP2115 |
| B | ASP2119 |
| B | ARG2124 |
| B | GLN2184 |
| B | LYS2210 |
| B | THR2211 |
| B | GLN2251 |
| B | ASN2254 |
| B | LYS2273 |
| B | HOH8004 |
| B | HOH8005 |
| B | HOH8009 |
| B | HOH8011 |
Functional Information from PROSITE/UniProt
| site_id | PS00723 |
| Number of Residues | 15 |
| Details | POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LIaDDim..DsgkfRRG |
| Chain | Residue | Details |
| A | LEU1112-GLY1126 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | ARG1124 | |
| A | TYR1250 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | ARG2124 | |
| B | TYR2250 |
