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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2Q50

Ensemble refinement of the protein crystal structure of a glyoxylate/hydroxypyruvate reductase from Homo sapiens

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0008465molecular_functionhydroxypyruvate reductase (NADH) activity
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0016618molecular_functionhydroxypyruvate reductase [NAD(P)H] activity
A0019752biological_processcarboxylic acid metabolic process
A0030267molecular_functionglyoxylate reductase (NADPH) activity
A0031406molecular_functioncarboxylic acid binding
A0042803molecular_functionprotein homodimerization activity
A0043648biological_processdicarboxylic acid metabolic process
A0046487biological_processglyoxylate metabolic process
A0050661molecular_functionNADP binding
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
A0070402molecular_functionNADPH binding
A0120509molecular_functionhydroxypyruvate reductase (NADPH) activity
A1902494cellular_componentcatalytic complex
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0008465molecular_functionhydroxypyruvate reductase (NADH) activity
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0016618molecular_functionhydroxypyruvate reductase [NAD(P)H] activity
B0019752biological_processcarboxylic acid metabolic process
B0030267molecular_functionglyoxylate reductase (NADPH) activity
B0031406molecular_functioncarboxylic acid binding
B0042803molecular_functionprotein homodimerization activity
B0043648biological_processdicarboxylic acid metabolic process
B0046487biological_processglyoxylate metabolic process
B0050661molecular_functionNADP binding
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
B0070402molecular_functionNADPH binding
B0120509molecular_functionhydroxypyruvate reductase (NADPH) activity
B1902494cellular_componentcatalytic complex
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005782cellular_componentperoxisomal matrix
C0005829cellular_componentcytosol
C0008465molecular_functionhydroxypyruvate reductase (NADH) activity
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0016618molecular_functionhydroxypyruvate reductase [NAD(P)H] activity
C0019752biological_processcarboxylic acid metabolic process
C0030267molecular_functionglyoxylate reductase (NADPH) activity
C0031406molecular_functioncarboxylic acid binding
C0042803molecular_functionprotein homodimerization activity
C0043648biological_processdicarboxylic acid metabolic process
C0046487biological_processglyoxylate metabolic process
C0050661molecular_functionNADP binding
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
C0070402molecular_functionNADPH binding
C0120509molecular_functionhydroxypyruvate reductase (NADPH) activity
C1902494cellular_componentcatalytic complex
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005782cellular_componentperoxisomal matrix
D0005829cellular_componentcytosol
D0008465molecular_functionhydroxypyruvate reductase (NADH) activity
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0016618molecular_functionhydroxypyruvate reductase [NAD(P)H] activity
D0019752biological_processcarboxylic acid metabolic process
D0030267molecular_functionglyoxylate reductase (NADPH) activity
D0031406molecular_functioncarboxylic acid binding
D0042803molecular_functionprotein homodimerization activity
D0043648biological_processdicarboxylic acid metabolic process
D0046487biological_processglyoxylate metabolic process
D0050661molecular_functionNADP binding
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
D0070402molecular_functionNADPH binding
D0120509molecular_functionhydroxypyruvate reductase (NADPH) activity
D1902494cellular_componentcatalytic complex
Functional Information from PROSITE/UniProt
site_idPS00671
Number of Residues17
DetailsD_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKeTaVFINiSRGdVVN
ChainResidueDetails
AMSE234-ASN250
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"16756993","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues56
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16756993","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsSite: {"description":"Raises pKa of active site His","evidences":[{"source":"PubMed","id":"16756993","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues5
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
AARG245
AASP269
AGLU274
AHIS293
AASP247
site_idCSA2
Number of Residues5
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
BARG245
BASP269
BGLU274
BHIS293
BASP247
site_idCSA3
Number of Residues5
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
CARG245
CASP269
CGLU274
CHIS293
CASP247
site_idCSA4
Number of Residues5
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
DARG245
DASP269
DGLU274
DHIS293
DASP247
site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
AGLU274
AHIS293
site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
BGLU274
BHIS293
site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
CGLU274
CHIS293
site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1gdh
ChainResidueDetails
DGLU274
DHIS293

243911

PDB entries from 2025-10-29

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