2Q2Q

Structure of D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas putida

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
D	0000166	molecular_function	nucleotide binding
D	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
E	0000166	molecular_function	nucleotide binding
E	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
F	0000166	molecular_function	nucleotide binding
F	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
G	0000166	molecular_function	nucleotide binding
G	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
G	0016491	molecular_function	oxidoreductase activity
H	0000166	molecular_function	nucleotide binding
H	0003858	molecular_function	3-hydroxybutyrate dehydrogenase activity
H	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD C 300

Chain	Residue
C	GLY12
C	ASN87
C	GLY89
C	LEU110
C	ILE137
C	ALA138
C	SER139
C	TYR152
C	LYS156
C	PRO182
C	GLY183
C	THR14
C	TRP184
C	VAL185
C	THR187
C	LEU189
C	VAL190
C	SER15
C	ILE17
C	ASN35
C	PHE37
C	ALA59
C	ASP60
C	LEU61

---

site_id	AC2
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAD D 300

Chain	Residue
D	GLY12
D	SER13
D	THR14
D	SER15
D	GLY16
D	ILE17
D	ASN35
D	PHE37
D	ALA59
D	ASP60
D	LEU61
D	ASN87
D	ALA88
D	GLY89
D	LYS106
D	ILE137
D	ALA138
D	SER139
D	TYR152
D	LYS156
D	PRO182
D	GLY183
D	TRP184
D	VAL185
D	THR187
D	PRO188
D	LEU189
D	VAL190
D	HOH343
D	HOH367

---

site_id	AC3
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAD E 300

Chain	Residue
E	GLY12
E	THR14
E	SER15
E	GLY16
E	ILE17
E	ASN35
E	GLY36
E	PHE37
E	ALA59
E	ASP60
E	LEU61
E	ASN87
E	ALA88
E	GLY89
E	LEU110
E	ILE137
E	ALA138
E	TYR152
E	LYS156
E	PRO182
E	GLY183
E	TRP184
E	VAL185
E	THR187
E	PRO188
E	LEU189
E	VAL190
E	HOH334
E	HOH344
E	HOH354

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD F 300

Chain	Residue
F	GLY89
F	LEU110
F	ALA138
F	SER139
F	TYR152
F	LYS156
F	PRO182
F	GLY183
F	TRP184
F	VAL185
F	THR187
F	LEU189
B	GLU102
B	HOH333
F	GLY12
F	THR14
F	SER15
F	GLY16
F	ILE17
F	ASN35
F	GLY36
F	PHE37
F	ALA59
F	ASP60
F	LEU61
F	ASN87
F	ALA88

---

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD G 300

Chain	Residue
G	GLY12
G	SER13
G	THR14
G	SER15
G	GLY16
G	ILE17
G	ASN35
G	PHE37
G	ALA59
G	ASP60
G	LEU61
G	ASN87
G	ALA88
G	GLY89
G	ILE137
G	ALA138
G	SER139
G	TYR152
G	LYS156
G	PRO182
G	GLY183
G	TRP184
G	VAL185
G	THR187
G	PRO188
G	LEU189
G	VAL190

---

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD H 300

Chain	Residue
A	GLU102
H	GLY12
H	THR14
H	SER15
H	GLY16
H	ILE17
H	ASN35
H	PHE37
H	ALA59
H	ASP60
H	LEU61
H	ASN87
H	ALA88
H	GLY89
H	LEU110
H	ILE137
H	ALA138
H	SER139
H	TYR152
H	LYS156
H	PRO182
H	GLY183
H	TRP184
H	VAL185
H	THR187

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvhglvgstgKaaYVAAKHGVvGLTkVVG

Chain	Residue	Details
A	SER139-GLY167

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