2Q0N

Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 592

Chain	Residue
A	ARG298
A	ARG359
A	ARG360
A	GLU361

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 593

Chain	Residue
A	SEP474
A	HOH70
A	ARG359
A	LEU362
A	ASN365
A	ARG439

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 594

Chain	Residue
A	ASN413
A	GLU414

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 403

Chain	Residue
A	LYS574
A	ARG591
B	ARG-5
B	ARG-3

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 595

Chain	Residue
A	LEU475
A	LEU521
A	ARG528
A	EDO596

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 596

Chain	Residue
A	ARG528
A	EDO595

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 597

Chain	Residue
A	HOH265
A	GLU396
A	PHE397
A	LEU398
A	GLY401

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 598

Chain	Residue
A	HOH273
A	HOH275
A	GLU399
A	GLN587

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 599

Chain	Residue
A	VAL407
A	HIS409
A	THR410

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK

Chain	Residue	Details
A	ILE327-LYS351

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Region: {"description":"GEF-interaction domain (GID)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26607847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26607847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"PDB data bank","title":"Crystal structure of the human p21-activated kinase 4.","authors":["Eswaran J.","Debreczeni J.E.","Bunkoczi G.","Filippakopoulos P.","Das S.","Fedorov O.","Sundstrom M.","Arrowsmith C.","Edwards A.","von Delft F.","Knapp S."]}},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP440
A	ASP444

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP440
A	LYS442

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR478
A	ASP440
A	LYS442

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	SER445
A	ASP440
A	LYS442

---