Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 400 |
| Chain | Residue |
| A | GLY8 |
| A | ILE40 |
| A | ASN48 |
| A | THR79 |
| A | ALA80 |
| A | VAL81 |
| A | THR110 |
| A | GLY111 |
| A | THR132 |
| A | CYS133 |
| A | CYS136 |
| A | GLY9 |
| A | VAL245 |
| A | GLY280 |
| A | ASP281 |
| A | LYS288 |
| A | GLN289 |
| A | VAL290 |
| A | ALA293 |
| A | HOH402 |
| A | HOH403 |
| A | HOH404 |
| A | GLY10 |
| A | HOH407 |
| A | HOH426 |
| A | HOH428 |
| A | HOH431 |
| A | HOH437 |
| A | HOH586 |
| A | HOH641 |
| A | PRO11 |
| A | ALA12 |
| A | GLU32 |
| A | LYS33 |
| A | GLY38 |
| A | GLN39 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | GLY151 |
| A | GLY152 |
| A | ASP153 |
| A | THR154 |
| A | GLU157 |
| A | HIS173 |
| A | ARG174 |
| A | ARG175 |
| A | ARG179 |
| A | VAL237 |
| A | GLY238 |
| A | TYR260 |
| A | HOH410 |
| A | HOH417 |
| A | HOH438 |
| A | HOH444 |
| A | HOH450 |
| A | HOH475 |
| A | HOH478 |
| A | HOH484 |
| A | HOH498 |
| A | HOH505 |
| A | HOH577 |
| A | HOH591 |
| A | HOH634 |
| A | HOH663 |
| A | HOH680 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD B 400 |
| Chain | Residue |
| B | GLY8 |
| B | GLY9 |
| B | GLY10 |
| B | PRO11 |
| B | ALA12 |
| B | GLU32 |
| B | LYS33 |
| B | GLY38 |
| B | GLN39 |
| B | ILE46 |
| B | ASN48 |
| B | THR79 |
| B | VAL81 |
| B | ALA109 |
| B | THR110 |
| B | GLY111 |
| B | CYS133 |
| B | CYS136 |
| B | VAL245 |
| B | GLY280 |
| B | ASP281 |
| B | LYS288 |
| B | GLN289 |
| B | VAL290 |
| B | ALA293 |
| B | HOH402 |
| B | HOH403 |
| B | HOH404 |
| B | HOH406 |
| B | HOH430 |
| B | HOH462 |
| B | HOH467 |
| B | HOH577 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAP B 401 |
| Chain | Residue |
| B | THR154 |
| B | GLU157 |
| B | HIS173 |
| B | ARG174 |
| B | ARG175 |
| B | ARG179 |
| B | VAL237 |
| B | GLY238 |
| B | TYR260 |
| B | HOH440 |
| B | HOH449 |
| B | HOH474 |
| B | HOH484 |
| B | HOH496 |
| B | HOH506 |
| B | HOH531 |
| B | GLY151 |
| B | GLY152 |
| B | ASP153 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YknkeVaVLGGGD |
| Chain | Residue | Details |
| A | CYS133-ASP153 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE31 | |
| B | PHE31 | |
| Chain | Residue | Details |
| A | GLU32 | |
| A | ASP281 | |
| B | GLU32 | |
| B | ASP281 | |
