2Q05

Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030430	cellular_component	host cell cytoplasm
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
A	0044423	cellular_component	virion component
A	0052031	biological_process	symbiont-mediated perturbation of host defense response
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006470	biological_process	protein dephosphorylation
B	0016311	biological_process	dephosphorylation
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030430	cellular_component	host cell cytoplasm
B	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
B	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
B	0044423	cellular_component	virion component
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0004725	molecular_function	protein tyrosine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006470	biological_process	protein dephosphorylation
C	0016311	biological_process	dephosphorylation
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030430	cellular_component	host cell cytoplasm
C	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
C	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
C	0044423	cellular_component	virion component
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0004725	molecular_function	protein tyrosine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006470	biological_process	protein dephosphorylation
D	0016311	biological_process	dephosphorylation
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030430	cellular_component	host cell cytoplasm
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
D	0044423	cellular_component	virion component
D	0052031	biological_process	symbiont-mediated perturbation of host defense response
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCaaGvnRSG

Chain	Residue	Details
A	VAL108-GLY118

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1848923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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