2PUA
CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0002057 | molecular_function | guanine binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 1900372 | biological_process | negative regulation of purine nucleotide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 6MP A 599 |
| Chain | Residue |
| A | TYR73 |
| A | PHE74 |
| A | SER124 |
| A | THR192 |
| A | ARG196 |
| A | PHE221 |
| A | ASP275 |
Functional Information from PROSITE/UniProt
| site_id | PS00356 |
| Number of Residues | 19 |
| Details | HTH_LACI_1 LacI-type HTH domain signature. IkDVAkrAnVSttTVshVI |
| Chain | Residue | Details |
| A | ILE4-ILE22 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | DNA_BIND: H-T-H motif |
| Chain | Residue | Details |
| A | LYS5-LYS24 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | DNA_BIND: |
| Chain | Residue | Details |
| A | ALA49-ASN57 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11781089, ECO:0000269|PubMed:9628480, ECO:0000269|Ref.17, ECO:0007744|PDB:1JFS, ECO:0007744|PDB:1VPW, ECO:0007744|PDB:1ZAY |
| Chain | Residue | Details |
| A | PHE74 | |
| A | ASN191 | |
| A | GLY193 | |
| A | GLU222 | |
| A | ASN276 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Is the key determinant of 6-oxopurine corepressor specificity |
| Chain | Residue | Details |
| A | ASN191 |
