2PTS

Crystal structure of wild type Escherichia coli adenylosuccinate lyase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006188	biological_process	IMP biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0006974	biological_process	DNA damage response
A	0009152	biological_process	purine ribonucleotide biosynthetic process
A	0016829	molecular_function	lyase activity
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
A	0097216	molecular_function	guanosine tetraphosphate binding

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSstMpHKvN

Chain	Residue	Details
A	GLY294-ASN303

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:17531264

Chain	Residue	Details
A	HIS171
A	SER295

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site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:17531264, ECO:0007744|PDB:2PTR

Chain	Residue	Details
A	ARG15
A	ASN90
A	THR122
A	GLN247
A	SER296
A	LYS301
A	ASN309
A	ARG335
A	SER340

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17531264, ECO:0007744|PDB:2PTQ

Chain	Residue	Details
A	HIS91

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	LYS94
A	LYS366

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1auw

Chain	Residue	Details
A	GLU308
A	LYS301

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1auw

Chain	Residue	Details
A	THR170
A	HIS171

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1auw

Chain	Residue	Details
A	HIS171

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1auw

Chain	Residue	Details
A	GLU311
A	LYS301

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