2PTH

PEPTIDYL-TRNA HYDROLASE FROM ESCHERICHIA COLI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004045	molecular_function	aminoacyl-tRNA hydrolase activity
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0016787	molecular_function	hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS01195
Number of Residues	14
Details	PEPT_TRNA_HYDROL_1 Peptidyl-tRNA hydrolase signature 1. YaaTRHNaGawFVD

Chain	Residue	Details
A	TYR15-ASP28

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site_id	PS01196
Number of Residues	11
Details	PEPT_TRNA_HYDROL_2 Peptidyl-tRNA hydrolase signature 2. GhggHNGLKDI

Chain	Residue	Details
A	GLY109-ILE119

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 931

Chain	Residue	Details
A	HIS20	proton shuttle (general acid/base)
A	ASN68	electrostatic stabiliser
A	ASP93	electrostatic stabiliser, modifies pKa
A	ASN114	electrostatic stabiliser

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