2PSR
HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000302 | biological_process | response to reactive oxygen species |
| A | 0001525 | biological_process | angiogenesis |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008544 | biological_process | epidermis development |
| A | 0010820 | biological_process | positive regulation of T cell chemotaxis |
| A | 0030216 | biological_process | keratinocyte differentiation |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043542 | biological_process | endothelial cell migration |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0050786 | molecular_function | RAGE receptor binding |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0071624 | biological_process | positive regulation of granulocyte chemotaxis |
| A | 0090026 | biological_process | positive regulation of monocyte chemotaxis |
| A | 0140486 | molecular_function | zinc ion sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 102 |
| Chain | Residue |
| A | ASP62 |
| A | ASN64 |
| A | ASP66 |
| A | LYS68 |
| A | GLU73 |
| A | HOH306 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 103 |
| Chain | Residue |
| A | HIS17 |
| A | ASP24 |
| A | HIS86 |
| A | HIS90 |
| site_id | CAA |
| Number of Residues | 5 |
| Details | REGULATORY CA2+ BINDING SITE |
| Chain | Residue |
| A | ASP62 |
| A | ASN64 |
| A | ASP66 |
| A | LYS68 |
| A | GLU73 |
| site_id | ZNA |
| Number of Residues | 4 |
| Details | ZN2+ BINDING SITE |
| Chain | Residue |
| A | HIS17 |
| A | ASP24 |
| A | HIS86 |
| A | HIS90 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"8526920","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
