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2PSN

Crystal structure of enolase1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000015cellular_componentphosphopyruvate hydratase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000287molecular_functionmagnesium ion binding
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0001222molecular_functiontranscription corepressor binding
A0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
A0003677molecular_functionDNA binding
A0003714molecular_functiontranscription corepressor activity
A0003723molecular_functionRNA binding
A0004634molecular_functionphosphopyruvate hydratase activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006094biological_processgluconeogenesis
A0006096biological_processglycolytic process
A0009615biological_processresponse to virus
A0009986cellular_componentcell surface
A0010756biological_processpositive regulation of plasminogen activation
A0016020cellular_componentmembrane
A0016829molecular_functionlyase activity
A0030308biological_processnegative regulation of cell growth
A0031430cellular_componentM band
A0042803molecular_functionprotein homodimerization activity
A0045296molecular_functioncadherin binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045933biological_processpositive regulation of muscle contraction
A0046872molecular_functionmetal ion binding
A0051020molecular_functionGTPase binding
A0061621biological_processcanonical glycolysis
A0070062cellular_componentextracellular exosome
A1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000015cellular_componentphosphopyruvate hydratase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000287molecular_functionmagnesium ion binding
B0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
B0001222molecular_functiontranscription corepressor binding
B0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
B0003677molecular_functionDNA binding
B0003714molecular_functiontranscription corepressor activity
B0003723molecular_functionRNA binding
B0004634molecular_functionphosphopyruvate hydratase activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006094biological_processgluconeogenesis
B0006096biological_processglycolytic process
B0009615biological_processresponse to virus
B0009986cellular_componentcell surface
B0010756biological_processpositive regulation of plasminogen activation
B0016020cellular_componentmembrane
B0016829molecular_functionlyase activity
B0030308biological_processnegative regulation of cell growth
B0031430cellular_componentM band
B0042803molecular_functionprotein homodimerization activity
B0045296molecular_functioncadherin binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0045933biological_processpositive regulation of muscle contraction
B0046872molecular_functionmetal ion binding
B0051020molecular_functionGTPase binding
B0061621biological_processcanonical glycolysis
B0070062cellular_componentextracellular exosome
B1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
B2001171biological_processpositive regulation of ATP biosynthetic process
C0000015cellular_componentphosphopyruvate hydratase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000287molecular_functionmagnesium ion binding
C0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
C0001222molecular_functiontranscription corepressor binding
C0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
C0003677molecular_functionDNA binding
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0004634molecular_functionphosphopyruvate hydratase activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006094biological_processgluconeogenesis
C0006096biological_processglycolytic process
C0009615biological_processresponse to virus
C0009986cellular_componentcell surface
C0010756biological_processpositive regulation of plasminogen activation
C0016020cellular_componentmembrane
C0016829molecular_functionlyase activity
C0030308biological_processnegative regulation of cell growth
C0031430cellular_componentM band
C0042803molecular_functionprotein homodimerization activity
C0045296molecular_functioncadherin binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0045933biological_processpositive regulation of muscle contraction
C0046872molecular_functionmetal ion binding
C0051020molecular_functionGTPase binding
C0061621biological_processcanonical glycolysis
C0070062cellular_componentextracellular exosome
C1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
C2001171biological_processpositive regulation of ATP biosynthetic process
D0000015cellular_componentphosphopyruvate hydratase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000287molecular_functionmagnesium ion binding
D0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
D0001222molecular_functiontranscription corepressor binding
D0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
D0003677molecular_functionDNA binding
D0003714molecular_functiontranscription corepressor activity
D0003723molecular_functionRNA binding
D0004634molecular_functionphosphopyruvate hydratase activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006094biological_processgluconeogenesis
D0006096biological_processglycolytic process
D0009615biological_processresponse to virus
D0009986cellular_componentcell surface
D0010756biological_processpositive regulation of plasminogen activation
D0016020cellular_componentmembrane
D0016829molecular_functionlyase activity
D0030308biological_processnegative regulation of cell growth
D0031430cellular_componentM band
D0042803molecular_functionprotein homodimerization activity
D0045296molecular_functioncadherin binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0045933biological_processpositive regulation of muscle contraction
D0046872molecular_functionmetal ion binding
D0051020molecular_functionGTPase binding
D0061621biological_processcanonical glycolysis
D0070062cellular_componentextracellular exosome
D1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
D2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 701
ChainResidue
AGLN165
AASP244
AGLU292
AASP317
ALYS342
AHOH712
AHOH889

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 702
ChainResidue
ALYS342
AHOH710
AHOH711
ASER39
AASP317

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 703
ChainResidue
BGLN165
BASP244
BGLU292
BASP317
BLYS342
BHOH711
BHOH712

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 704
ChainResidue
BSER39
BASP317
BLYS342
BHOH713
BHOH718

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG C 705
ChainResidue
CGLN165
CASP244
CGLU292
CASP317
CLYS342
CHOH712
CHOH831

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG C 706
ChainResidue
CSER39
CASP317
CLYS342
CHOH732

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG D 707
ChainResidue
DGLN165
DASP244
DGLU292
DASP317
DLYS342
DHOH721
DHOH800

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 708
ChainResidue
DSER39
DASP317
DLYS342
DHOH757
DHOH801

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 A 709
ChainResidue
AGLY37
AALA38
ASER39
AHIS157
AGLN165
ALYS342
AARG371
ASER372
AHOH711
AHOH736

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 B 710
ChainResidue
BGLY37
BALA38
BSER39
BHIS157
BGLN165
BLYS342
BARG371
BSER372
BHOH713
BHOH722

site_idBC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 C 711
ChainResidue
CGLY37
CALA38
CSER39
CHIS157
CGLN165
CLYS342
CARG371
CSER372

site_idBC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 D 712
ChainResidue
DGLY37
DALA38
DSER39
DHIS157
DGLN165
DLYS342
DARG371
DSER372
DHOH714

Functional Information from PROSITE/UniProt
site_idPS00164
Number of Residues14
DetailsENOLASE Enolase signature. LLLKvNQIGSVTES
ChainResidueDetails
ALEU339-SER352

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P00924
ChainResidueDetails
AGLU209
BGLU209
CGLU209
DGLU209

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00924
ChainResidueDetails
ALYS342
BLYS342
CLYS342
DLYS342

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18560153
ChainResidueDetails
ASER39
AASP244
BSER39
BASP244
CSER39
CASP244
DSER39
DASP244

site_idSWS_FT_FI4
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00924
ChainResidueDetails
AHIS157
BASP317
BSER369
BLYS393
CHIS157
CGLU166
CGLU292
CASP317
CSER369
CLYS393
DHIS157
AGLU166
DGLU166
DGLU292
DASP317
DSER369
DLYS393
AGLU292
AASP317
ASER369
ALYS393
BHIS157
BGLU166
BGLU292

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N-acetylserine => ECO:0000269|Ref.14, ECO:0007744|PubMed:25944712
ChainResidueDetails
ASER1
BSER1
CSER1
DSER1

site_idSWS_FT_FI6
Number of Residues32
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS4
BLYS63
BLYS70
BLYS125
BLYS192
BLYS198
BLYS255
BLYS284
CLYS4
CLYS63
CLYS70
ALYS63
CLYS125
CLYS192
CLYS198
CLYS255
CLYS284
DLYS4
DLYS63
DLYS70
DLYS125
DLYS192
ALYS70
DLYS198
DLYS255
DLYS284
ALYS125
ALYS192
ALYS198
ALYS255
ALYS284
BLYS4

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER26
BSER26
CSER26
DSER26

site_idSWS_FT_FI8
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR43
ATYR286
BTYR43
BTYR286
CTYR43
CTYR286
DTYR43
DTYR286

site_idSWS_FT_FI9
Number of Residues16
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P17182
ChainResidueDetails
ALYS59
CLYS88
CLYS227
CLYS419
DLYS59
DLYS88
DLYS227
DLYS419
ALYS88
ALYS227
ALYS419
BLYS59
BLYS88
BLYS227
BLYS419
CLYS59

site_idSWS_FT_FI10
Number of Residues16
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P17182
ChainResidueDetails
ALYS91
CLYS334
CLYS342
CLYS405
DLYS91
DLYS334
DLYS342
DLYS405
ALYS334
ALYS342
ALYS405
BLYS91
BLYS334
BLYS342
BLYS405
CLYS91

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P17182
ChainResidueDetails
ALYS201
BLYS201
CLYS201
DLYS201

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: N6-malonyllysine; alternate => ECO:0000269|PubMed:21908771
ChainResidueDetails
ALYS232
BLYS232
CLYS232
DLYS232

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER253
BSER253
CSER253
DSER253

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER262
BSER262
CSER262
DSER262

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER271
BSER271
CSER271
DSER271

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS280
BLYS280
CLYS280
DLYS280

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER290
BSER290
CSER290
DSER290

site_idSWS_FT_FI18
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS201
BLYS201
CLYS201
DLYS201

218853

PDB entries from 2024-04-24

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