2PSN
Crystal structure of enolase1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000015 | cellular_component | phosphopyruvate hydratase complex |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
A | 0001222 | molecular_function | transcription corepressor binding |
A | 0001227 | molecular_function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
A | 0003677 | molecular_function | DNA binding |
A | 0003714 | molecular_function | transcription corepressor activity |
A | 0003723 | molecular_function | RNA binding |
A | 0004634 | molecular_function | phosphopyruvate hydratase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005640 | cellular_component | nuclear outer membrane |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005938 | cellular_component | cell cortex |
A | 0006094 | biological_process | gluconeogenesis |
A | 0006096 | biological_process | glycolytic process |
A | 0009615 | biological_process | response to virus |
A | 0009986 | cellular_component | cell surface |
A | 0010756 | biological_process | positive regulation of plasminogen activation |
A | 0016020 | cellular_component | membrane |
A | 0016829 | molecular_function | lyase activity |
A | 0030308 | biological_process | negative regulation of cell growth |
A | 0031430 | cellular_component | M band |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0045296 | molecular_function | cadherin binding |
A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
A | 0045933 | biological_process | positive regulation of muscle contraction |
A | 0046872 | molecular_function | metal ion binding |
A | 0051020 | molecular_function | GTPase binding |
A | 0061621 | biological_process | canonical glycolysis |
A | 0070062 | cellular_component | extracellular exosome |
A | 1903298 | biological_process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
A | 2001171 | biological_process | positive regulation of ATP biosynthetic process |
B | 0000015 | cellular_component | phosphopyruvate hydratase complex |
B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
B | 0001222 | molecular_function | transcription corepressor binding |
B | 0001227 | molecular_function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
B | 0003677 | molecular_function | DNA binding |
B | 0003714 | molecular_function | transcription corepressor activity |
B | 0003723 | molecular_function | RNA binding |
B | 0004634 | molecular_function | phosphopyruvate hydratase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005615 | cellular_component | extracellular space |
B | 0005634 | cellular_component | nucleus |
B | 0005640 | cellular_component | nuclear outer membrane |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005938 | cellular_component | cell cortex |
B | 0006094 | biological_process | gluconeogenesis |
B | 0006096 | biological_process | glycolytic process |
B | 0009615 | biological_process | response to virus |
B | 0009986 | cellular_component | cell surface |
B | 0010756 | biological_process | positive regulation of plasminogen activation |
B | 0016020 | cellular_component | membrane |
B | 0016829 | molecular_function | lyase activity |
B | 0030308 | biological_process | negative regulation of cell growth |
B | 0031430 | cellular_component | M band |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0045296 | molecular_function | cadherin binding |
B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
B | 0045933 | biological_process | positive regulation of muscle contraction |
B | 0046872 | molecular_function | metal ion binding |
B | 0051020 | molecular_function | GTPase binding |
B | 0061621 | biological_process | canonical glycolysis |
B | 0070062 | cellular_component | extracellular exosome |
B | 1903298 | biological_process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
B | 2001171 | biological_process | positive regulation of ATP biosynthetic process |
C | 0000015 | cellular_component | phosphopyruvate hydratase complex |
C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
C | 0001222 | molecular_function | transcription corepressor binding |
C | 0001227 | molecular_function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
C | 0003677 | molecular_function | DNA binding |
C | 0003714 | molecular_function | transcription corepressor activity |
C | 0003723 | molecular_function | RNA binding |
C | 0004634 | molecular_function | phosphopyruvate hydratase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005615 | cellular_component | extracellular space |
C | 0005634 | cellular_component | nucleus |
C | 0005640 | cellular_component | nuclear outer membrane |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0005938 | cellular_component | cell cortex |
C | 0006094 | biological_process | gluconeogenesis |
C | 0006096 | biological_process | glycolytic process |
C | 0009615 | biological_process | response to virus |
C | 0009986 | cellular_component | cell surface |
C | 0010756 | biological_process | positive regulation of plasminogen activation |
C | 0016020 | cellular_component | membrane |
C | 0016829 | molecular_function | lyase activity |
C | 0030308 | biological_process | negative regulation of cell growth |
C | 0031430 | cellular_component | M band |
C | 0042803 | molecular_function | protein homodimerization activity |
C | 0045296 | molecular_function | cadherin binding |
C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
C | 0045933 | biological_process | positive regulation of muscle contraction |
C | 0046872 | molecular_function | metal ion binding |
C | 0051020 | molecular_function | GTPase binding |
C | 0061621 | biological_process | canonical glycolysis |
C | 0070062 | cellular_component | extracellular exosome |
C | 1903298 | biological_process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
C | 2001171 | biological_process | positive regulation of ATP biosynthetic process |
D | 0000015 | cellular_component | phosphopyruvate hydratase complex |
D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
D | 0001222 | molecular_function | transcription corepressor binding |
D | 0001227 | molecular_function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
D | 0003677 | molecular_function | DNA binding |
D | 0003714 | molecular_function | transcription corepressor activity |
D | 0003723 | molecular_function | RNA binding |
D | 0004634 | molecular_function | phosphopyruvate hydratase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005615 | cellular_component | extracellular space |
D | 0005634 | cellular_component | nucleus |
D | 0005640 | cellular_component | nuclear outer membrane |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005886 | cellular_component | plasma membrane |
D | 0005938 | cellular_component | cell cortex |
D | 0006094 | biological_process | gluconeogenesis |
D | 0006096 | biological_process | glycolytic process |
D | 0009615 | biological_process | response to virus |
D | 0009986 | cellular_component | cell surface |
D | 0010756 | biological_process | positive regulation of plasminogen activation |
D | 0016020 | cellular_component | membrane |
D | 0016829 | molecular_function | lyase activity |
D | 0030308 | biological_process | negative regulation of cell growth |
D | 0031430 | cellular_component | M band |
D | 0042803 | molecular_function | protein homodimerization activity |
D | 0045296 | molecular_function | cadherin binding |
D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
D | 0045933 | biological_process | positive regulation of muscle contraction |
D | 0046872 | molecular_function | metal ion binding |
D | 0051020 | molecular_function | GTPase binding |
D | 0061621 | biological_process | canonical glycolysis |
D | 0070062 | cellular_component | extracellular exosome |
D | 1903298 | biological_process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
D | 2001171 | biological_process | positive regulation of ATP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG A 701 |
Chain | Residue |
A | GLN165 |
A | ASP244 |
A | GLU292 |
A | ASP317 |
A | LYS342 |
A | HOH712 |
A | HOH889 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 702 |
Chain | Residue |
A | LYS342 |
A | HOH710 |
A | HOH711 |
A | SER39 |
A | ASP317 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG B 703 |
Chain | Residue |
B | GLN165 |
B | ASP244 |
B | GLU292 |
B | ASP317 |
B | LYS342 |
B | HOH711 |
B | HOH712 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 704 |
Chain | Residue |
B | SER39 |
B | ASP317 |
B | LYS342 |
B | HOH713 |
B | HOH718 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG C 705 |
Chain | Residue |
C | GLN165 |
C | ASP244 |
C | GLU292 |
C | ASP317 |
C | LYS342 |
C | HOH712 |
C | HOH831 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG C 706 |
Chain | Residue |
C | SER39 |
C | ASP317 |
C | LYS342 |
C | HOH732 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG D 707 |
Chain | Residue |
D | GLN165 |
D | ASP244 |
D | GLU292 |
D | ASP317 |
D | LYS342 |
D | HOH721 |
D | HOH800 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 708 |
Chain | Residue |
D | SER39 |
D | ASP317 |
D | LYS342 |
D | HOH757 |
D | HOH801 |
site_id | AC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PO4 A 709 |
Chain | Residue |
A | GLY37 |
A | ALA38 |
A | SER39 |
A | HIS157 |
A | GLN165 |
A | LYS342 |
A | ARG371 |
A | SER372 |
A | HOH711 |
A | HOH736 |
site_id | BC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PO4 B 710 |
Chain | Residue |
B | GLY37 |
B | ALA38 |
B | SER39 |
B | HIS157 |
B | GLN165 |
B | LYS342 |
B | ARG371 |
B | SER372 |
B | HOH713 |
B | HOH722 |
site_id | BC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 C 711 |
Chain | Residue |
C | GLY37 |
C | ALA38 |
C | SER39 |
C | HIS157 |
C | GLN165 |
C | LYS342 |
C | ARG371 |
C | SER372 |
site_id | BC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 D 712 |
Chain | Residue |
D | GLY37 |
D | ALA38 |
D | SER39 |
D | HIS157 |
D | GLN165 |
D | LYS342 |
D | ARG371 |
D | SER372 |
D | HOH714 |
Functional Information from PROSITE/UniProt
site_id | PS00164 |
Number of Residues | 14 |
Details | ENOLASE Enolase signature. LLLKvNQIGSVTES |
Chain | Residue | Details |
A | LEU339-SER352 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P00924 |
Chain | Residue | Details |
A | GLU209 | |
B | GLU209 | |
C | GLU209 | |
D | GLU209 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00924 |
Chain | Residue | Details |
A | LYS342 | |
B | LYS342 | |
C | LYS342 | |
D | LYS342 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18560153 |
Chain | Residue | Details |
A | SER39 | |
A | ASP244 | |
B | SER39 | |
B | ASP244 | |
C | SER39 | |
C | ASP244 | |
D | SER39 | |
D | ASP244 |
site_id | SWS_FT_FI4 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00924 |
Chain | Residue | Details |
A | HIS157 | |
B | ASP317 | |
B | SER369 | |
B | LYS393 | |
C | HIS157 | |
C | GLU166 | |
C | GLU292 | |
C | ASP317 | |
C | SER369 | |
C | LYS393 | |
D | HIS157 | |
A | GLU166 | |
D | GLU166 | |
D | GLU292 | |
D | ASP317 | |
D | SER369 | |
D | LYS393 | |
A | GLU292 | |
A | ASP317 | |
A | SER369 | |
A | LYS393 | |
B | HIS157 | |
B | GLU166 | |
B | GLU292 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: N-acetylserine => ECO:0000269|Ref.14, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | SER1 | |
B | SER1 | |
C | SER1 | |
D | SER1 |
site_id | SWS_FT_FI6 |
Number of Residues | 32 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS4 | |
B | LYS63 | |
B | LYS70 | |
B | LYS125 | |
B | LYS192 | |
B | LYS198 | |
B | LYS255 | |
B | LYS284 | |
C | LYS4 | |
C | LYS63 | |
C | LYS70 | |
A | LYS63 | |
C | LYS125 | |
C | LYS192 | |
C | LYS198 | |
C | LYS255 | |
C | LYS284 | |
D | LYS4 | |
D | LYS63 | |
D | LYS70 | |
D | LYS125 | |
D | LYS192 | |
A | LYS70 | |
D | LYS198 | |
D | LYS255 | |
D | LYS284 | |
A | LYS125 | |
A | LYS192 | |
A | LYS198 | |
A | LYS255 | |
A | LYS284 | |
B | LYS4 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER26 | |
B | SER26 | |
C | SER26 | |
D | SER26 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | TYR43 | |
A | TYR286 | |
B | TYR43 | |
B | TYR286 | |
C | TYR43 | |
C | TYR286 | |
D | TYR43 | |
D | TYR286 |
site_id | SWS_FT_FI9 |
Number of Residues | 16 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P17182 |
Chain | Residue | Details |
A | LYS59 | |
C | LYS88 | |
C | LYS227 | |
C | LYS419 | |
D | LYS59 | |
D | LYS88 | |
D | LYS227 | |
D | LYS419 | |
A | LYS88 | |
A | LYS227 | |
A | LYS419 | |
B | LYS59 | |
B | LYS88 | |
B | LYS227 | |
B | LYS419 | |
C | LYS59 |
site_id | SWS_FT_FI10 |
Number of Residues | 16 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P17182 |
Chain | Residue | Details |
A | LYS91 | |
C | LYS334 | |
C | LYS342 | |
C | LYS405 | |
D | LYS91 | |
D | LYS334 | |
D | LYS342 | |
D | LYS405 | |
A | LYS334 | |
A | LYS342 | |
A | LYS405 | |
B | LYS91 | |
B | LYS334 | |
B | LYS342 | |
B | LYS405 | |
C | LYS91 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P17182 |
Chain | Residue | Details |
A | LYS201 | |
B | LYS201 | |
C | LYS201 | |
D | LYS201 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | MOD_RES: N6-malonyllysine; alternate => ECO:0000269|PubMed:21908771 |
Chain | Residue | Details |
A | LYS232 | |
B | LYS232 | |
C | LYS232 | |
D | LYS232 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER253 | |
B | SER253 | |
C | SER253 | |
D | SER253 |
site_id | SWS_FT_FI14 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER262 | |
B | SER262 | |
C | SER262 | |
D | SER262 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER271 | |
B | SER271 | |
C | SER271 | |
D | SER271 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS280 | |
B | LYS280 | |
C | LYS280 | |
D | LYS280 |
site_id | SWS_FT_FI17 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER290 | |
B | SER290 | |
C | SER290 | |
D | SER290 |
site_id | SWS_FT_FI18 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS201 | |
B | LYS201 | |
C | LYS201 | |
D | LYS201 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
A | GLU209 | |
A | GLU166 | |
A | HIS370 | |
A | LYS393 |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
B | LYS342 | |
B | HIS189 |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
C | LYS342 | |
C | HIS189 |
site_id | CSA12 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
D | LYS342 | |
D | HIS189 |
site_id | CSA13 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
A | LYS342 | |
A | VAL240 |
site_id | CSA14 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
B | LYS342 | |
B | VAL240 |
site_id | CSA15 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
C | LYS342 | |
C | VAL240 |
site_id | CSA16 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
D | LYS342 | |
D | VAL240 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
B | GLU209 | |
B | GLU166 | |
B | HIS370 | |
B | LYS393 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
C | GLU209 | |
C | GLU166 | |
C | HIS370 | |
C | LYS393 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
D | GLU209 | |
D | GLU166 | |
D | HIS370 | |
D | LYS393 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
A | LYS342 | |
A | GLU209 | |
A | GLU166 | |
A | HIS370 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
B | LYS342 | |
B | GLU209 | |
B | GLU166 | |
B | HIS370 |
site_id | CSA7 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
C | LYS342 | |
C | GLU209 | |
C | GLU166 | |
C | HIS370 |
site_id | CSA8 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
D | LYS342 | |
D | GLU209 | |
D | GLU166 | |
D | HIS370 |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1els |
Chain | Residue | Details |
A | LYS342 | |
A | HIS189 |