2PS1
S. cerevisiae orotate phosphoribosyltransferase complexed with orotic acid and PRPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| A | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
| B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| B | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIIDDVMTAGtA |
| Chain | Residue | Details |
| A | ILE127-ALA139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS29 | |
| A | TYR75 | |
| A | LYS106 | |
| A | ASP131 | |
| B | LYS29 | |
| B | TYR75 | |
| B | LYS106 | |
| B | ASP131 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE37 | |
| B | HIS111 | |
| B | THR135 | |
| B | ARG163 | |
| A | ARG105 | |
| A | LYS109 | |
| A | HIS111 | |
| A | THR135 | |
| A | ARG163 | |
| B | PHE37 | |
| B | ARG105 | |
| B | LYS109 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER212 | |
| A | SER224 | |
| B | SER212 | |
| B | SER224 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| A | LYS109 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| B | LYS109 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| A | LYS76 | |
| A | ASP110 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oro |
| Chain | Residue | Details |
| B | LYS76 | |
| B | ASP110 |
