2PRZ

S. cerevisiae orotate phosphoribosyltransferase complexed with OMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1

Chain	Residue
A	TYR75
A	LYS76
B	ARG105

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 2

Chain	Residue
C	TYR75
C	LYS76

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 225

Chain	Residue
C	ARG105
D	TYR75
D	LYS76

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 225

Chain	Residue
B	TYR75
B	LYS76
A	ARG105

---

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE OMP A 450

Chain	Residue
A	LEU28
A	LYS29
A	PHE37
A	PHE38
A	ASP132
A	VAL133
A	MET134
A	THR135
A	ALA136
A	GLY137
A	THR138
A	ALA139
A	ARG163
A	HOH453
A	HOH457
A	HOH458
A	HOH465
A	HOH482
A	HOH501

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE OMP B 550

Chain	Residue
B	LEU28
B	LYS29
B	PHE37
B	PHE38
B	ASP132
B	VAL133
B	MET134
B	THR135
B	ALA136
B	GLY137
B	THR138
B	ALA139
B	ARG163
B	HOH554
B	HOH559
B	HOH560
B	HOH577

---

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE OMP C 650

Chain	Residue
C	LEU28
C	LYS29
C	PHE37
C	PHE38
C	ASP132
C	VAL133
C	MET134
C	THR135
C	ALA136
C	GLY137
C	THR138
C	ALA139
C	ARG163
C	HOH652
C	HOH654
C	HOH671
C	HOH698
C	HOH718
C	HOH728

---

site_id	AC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE OMP D 750

Chain	Residue
D	LEU28
D	LYS29
D	PHE37
D	PHE38
D	ASP132
D	VAL133
D	MET134
D	THR135
D	ALA136
D	GLY137
D	THR138
D	ALA139
D	ARG163
D	HOH753
D	HOH754
D	HOH756
D	HOH787
D	HOH815
D	HOH835

---

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIIDDVMTAGtA

Chain	Residue	Details
A	ILE127-ALA139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Binding site: {"description":"in other chain","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1l1r

Chain	Residue	Details
A	LYS76

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1l1r

Chain	Residue	Details
B	LYS76

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1l1r

Chain	Residue	Details
C	LYS76

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1l1r

Chain	Residue	Details
D	LYS76

---