2PRZ
S. cerevisiae orotate phosphoribosyltransferase complexed with OMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| C | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| D | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | TYR75 |
| A | LYS76 |
| B | ARG105 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 2 |
| Chain | Residue |
| C | TYR75 |
| C | LYS76 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 225 |
| Chain | Residue |
| C | ARG105 |
| D | TYR75 |
| D | LYS76 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 225 |
| Chain | Residue |
| B | TYR75 |
| B | LYS76 |
| A | ARG105 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE OMP A 450 |
| Chain | Residue |
| A | LEU28 |
| A | LYS29 |
| A | PHE37 |
| A | PHE38 |
| A | ASP132 |
| A | VAL133 |
| A | MET134 |
| A | THR135 |
| A | ALA136 |
| A | GLY137 |
| A | THR138 |
| A | ALA139 |
| A | ARG163 |
| A | HOH453 |
| A | HOH457 |
| A | HOH458 |
| A | HOH465 |
| A | HOH482 |
| A | HOH501 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE OMP B 550 |
| Chain | Residue |
| B | LEU28 |
| B | LYS29 |
| B | PHE37 |
| B | PHE38 |
| B | ASP132 |
| B | VAL133 |
| B | MET134 |
| B | THR135 |
| B | ALA136 |
| B | GLY137 |
| B | THR138 |
| B | ALA139 |
| B | ARG163 |
| B | HOH554 |
| B | HOH559 |
| B | HOH560 |
| B | HOH577 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE OMP C 650 |
| Chain | Residue |
| C | LEU28 |
| C | LYS29 |
| C | PHE37 |
| C | PHE38 |
| C | ASP132 |
| C | VAL133 |
| C | MET134 |
| C | THR135 |
| C | ALA136 |
| C | GLY137 |
| C | THR138 |
| C | ALA139 |
| C | ARG163 |
| C | HOH652 |
| C | HOH654 |
| C | HOH671 |
| C | HOH698 |
| C | HOH718 |
| C | HOH728 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE OMP D 750 |
| Chain | Residue |
| D | LEU28 |
| D | LYS29 |
| D | PHE37 |
| D | PHE38 |
| D | ASP132 |
| D | VAL133 |
| D | MET134 |
| D | THR135 |
| D | ALA136 |
| D | GLY137 |
| D | THR138 |
| D | ALA139 |
| D | ARG163 |
| D | HOH753 |
| D | HOH754 |
| D | HOH756 |
| D | HOH787 |
| D | HOH815 |
| D | HOH835 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIIDDVMTAGtA |
| Chain | Residue | Details |
| A | ILE127-ALA139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: in other chain => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS29 | |
| C | TYR75 | |
| C | LYS106 | |
| C | ASP131 | |
| D | LYS29 | |
| D | TYR75 | |
| D | LYS106 | |
| D | ASP131 | |
| A | TYR75 | |
| A | LYS106 | |
| A | ASP131 | |
| B | LYS29 | |
| B | TYR75 | |
| B | LYS106 | |
| B | ASP131 | |
| C | LYS29 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE37 | |
| B | HIS111 | |
| B | THR135 | |
| B | ARG163 | |
| C | PHE37 | |
| C | ARG105 | |
| C | LYS109 | |
| C | HIS111 | |
| C | THR135 | |
| C | ARG163 | |
| D | PHE37 | |
| A | ARG105 | |
| D | ARG105 | |
| D | LYS109 | |
| D | HIS111 | |
| D | THR135 | |
| D | ARG163 | |
| A | LYS109 | |
| A | HIS111 | |
| A | THR135 | |
| A | ARG163 | |
| B | PHE37 | |
| B | ARG105 | |
| B | LYS109 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER212 | |
| A | SER224 | |
| B | SER212 | |
| B | SER224 | |
| C | SER212 | |
| C | SER224 | |
| D | SER212 | |
| D | SER224 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1l1r |
| Chain | Residue | Details |
| A | LYS76 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1l1r |
| Chain | Residue | Details |
| B | LYS76 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1l1r |
| Chain | Residue | Details |
| C | LYS76 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1l1r |
| Chain | Residue | Details |
| D | LYS76 |
