2PRZ
S. cerevisiae orotate phosphoribosyltransferase complexed with OMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
A | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
B | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
C | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
C | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
C | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
D | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
D | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
D | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 1 |
Chain | Residue |
A | TYR75 |
A | LYS76 |
B | ARG105 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 2 |
Chain | Residue |
C | TYR75 |
C | LYS76 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL D 225 |
Chain | Residue |
C | ARG105 |
D | TYR75 |
D | LYS76 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 225 |
Chain | Residue |
B | TYR75 |
B | LYS76 |
A | ARG105 |
site_id | AC5 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE OMP A 450 |
Chain | Residue |
A | LEU28 |
A | LYS29 |
A | PHE37 |
A | PHE38 |
A | ASP132 |
A | VAL133 |
A | MET134 |
A | THR135 |
A | ALA136 |
A | GLY137 |
A | THR138 |
A | ALA139 |
A | ARG163 |
A | HOH453 |
A | HOH457 |
A | HOH458 |
A | HOH465 |
A | HOH482 |
A | HOH501 |
site_id | AC6 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE OMP B 550 |
Chain | Residue |
B | LEU28 |
B | LYS29 |
B | PHE37 |
B | PHE38 |
B | ASP132 |
B | VAL133 |
B | MET134 |
B | THR135 |
B | ALA136 |
B | GLY137 |
B | THR138 |
B | ALA139 |
B | ARG163 |
B | HOH554 |
B | HOH559 |
B | HOH560 |
B | HOH577 |
site_id | AC7 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE OMP C 650 |
Chain | Residue |
C | LEU28 |
C | LYS29 |
C | PHE37 |
C | PHE38 |
C | ASP132 |
C | VAL133 |
C | MET134 |
C | THR135 |
C | ALA136 |
C | GLY137 |
C | THR138 |
C | ALA139 |
C | ARG163 |
C | HOH652 |
C | HOH654 |
C | HOH671 |
C | HOH698 |
C | HOH718 |
C | HOH728 |
site_id | AC8 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE OMP D 750 |
Chain | Residue |
D | LEU28 |
D | LYS29 |
D | PHE37 |
D | PHE38 |
D | ASP132 |
D | VAL133 |
D | MET134 |
D | THR135 |
D | ALA136 |
D | GLY137 |
D | THR138 |
D | ALA139 |
D | ARG163 |
D | HOH753 |
D | HOH754 |
D | HOH756 |
D | HOH787 |
D | HOH815 |
D | HOH835 |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIIDDVMTAGtA |
Chain | Residue | Details |
A | ILE127-ALA139 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: in other chain => ECO:0000250 |
Chain | Residue | Details |
A | LYS29 | |
C | TYR75 | |
C | LYS106 | |
C | ASP131 | |
D | LYS29 | |
D | TYR75 | |
D | LYS106 | |
D | ASP131 | |
A | TYR75 | |
A | LYS106 | |
A | ASP131 | |
B | LYS29 | |
B | TYR75 | |
B | LYS106 | |
B | ASP131 | |
C | LYS29 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | PHE37 | |
B | HIS111 | |
B | THR135 | |
B | ARG163 | |
C | PHE37 | |
C | ARG105 | |
C | LYS109 | |
C | HIS111 | |
C | THR135 | |
C | ARG163 | |
D | PHE37 | |
A | ARG105 | |
D | ARG105 | |
D | LYS109 | |
D | HIS111 | |
D | THR135 | |
D | ARG163 | |
A | LYS109 | |
A | HIS111 | |
A | THR135 | |
A | ARG163 | |
B | PHE37 | |
B | ARG105 | |
B | LYS109 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER212 | |
A | SER224 | |
B | SER212 | |
B | SER224 | |
C | SER212 | |
C | SER224 | |
D | SER212 | |
D | SER224 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1l1r |
Chain | Residue | Details |
A | LYS76 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1l1r |
Chain | Residue | Details |
B | LYS76 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1l1r |
Chain | Residue | Details |
C | LYS76 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1l1r |
Chain | Residue | Details |
D | LYS76 |