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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2PQ8

MYST histone acetyltransferase 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
ACYS210
ACYS213
AHIS226
ACYS230
site_idAC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE COA A 601
ChainResidue
AHOH113
AHOH121
AHOH122
AHOH144
APHE270
ALEU271
AILE317
ALEU318
ATHR319
AGLN324
AARG325
AARG326
AGLY327
AGLY329
ALYS330
ASER354
ALEU356
ALEU359
ASER360
ASER363
AUNX701
AHOH13
AHOH23
AHOH24
AHOH50
AHOH103
site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 701
ChainResidue
AILE317
ACOA601
site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 702
ChainResidue
AHIS297
AILE298
ATYR323
site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 703
ChainResidue
ALYS215
AILE258
AASN262
site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 704
ChainResidue
AGLU239
AARG274
ATHR275
site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE UNX A 705
ChainResidue
AHOH30
ATYR219
AGLU220
ALYS221
site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 706
ChainResidue
AARG233
AGLN234
site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 707
ChainResidue
AGLU250
AASP252
site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 708
ChainResidue
APHE283
APHE285
site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 709
ChainResidue
ATYR187
AGLU188
site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 710
ChainResidue
AHOH14
AASP190
site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 711
ChainResidue
APRO236
AGLY237
AHIS256
site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE UNX A 712
ChainResidue
AHOH55
AGLY185
ALEU209
AGLU211
ATYR223
site_idBC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE UNX A 713
ChainResidue
AGLN393
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsZinc finger: {"description":"C2HC MYST-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22020126","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"21217699","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27768893","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33657400","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21217699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21691301","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22020126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27382063","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29321206","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"MYST histone acetyltransferase 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2GIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PQ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TOB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29321206","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WCI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21217699","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"MYST histone acetyltransferase 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2GIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21217699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"21217699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21691301","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22020126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22547026","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22918831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27382063","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"MYST histone acetyltransferase 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2GIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1mj9
ChainResidueDetails
AGLU350
ACYS316

243911

PDB entries from 2025-10-29

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