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2PQ8

MYST histone acetyltransferase 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
ACYS210
ACYS213
AHIS226
ACYS230

site_idAC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE COA A 601
ChainResidue
AHOH113
AHOH121
AHOH122
AHOH144
APHE270
ALEU271
AILE317
ALEU318
ATHR319
AGLN324
AARG325
AARG326
AGLY327
AGLY329
ALYS330
ASER354
ALEU356
ALEU359
ASER360
ASER363
AUNX701
AHOH13
AHOH23
AHOH24
AHOH50
AHOH103

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 701
ChainResidue
AILE317
ACOA601

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 702
ChainResidue
AHIS297
AILE298
ATYR323

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 703
ChainResidue
ALYS215
AILE258
AASN262

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 704
ChainResidue
AGLU239
AARG274
ATHR275

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE UNX A 705
ChainResidue
AHOH30
ATYR219
AGLU220
ALYS221

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 706
ChainResidue
AARG233
AGLN234

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 707
ChainResidue
AGLU250
AASP252

site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 708
ChainResidue
APHE283
APHE285

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 709
ChainResidue
ATYR187
AGLU188

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE UNX A 710
ChainResidue
AHOH14
AASP190

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE UNX A 711
ChainResidue
APRO236
AGLY237
AHIS256

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE UNX A 712
ChainResidue
AHOH55
AGLY185
ALEU209
AGLU211
ATYR223

site_idBC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE UNX A 713
ChainResidue
AGLN393

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000269|PubMed:22020126
ChainResidueDetails
ALEU207-TRP232

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:21217699, ECO:0000305|PubMed:27768893, ECO:0000305|PubMed:33657400
ChainResidueDetails
AGLU350

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:27382063, ECO:0000269|PubMed:29321206, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV, ECO:0007744|PDB:2PQ8, ECO:0007744|PDB:2Y0M, ECO:0007744|PDB:3QAH, ECO:0007744|PDB:3TOA, ECO:0007744|PDB:3TOB, ECO:0007744|PDB:4DNC, ECO:0007744|PDB:5J8C, ECO:0007744|PDB:5J8F, ECO:0007744|PDB:5WCI
ChainResidueDetails
ACYS210
ACYS213
AHIS226
ACYS230

site_idSWS_FT_FI4
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|PubMed:29321206, ECO:0007744|PDB:5WCI
ChainResidueDetails
AILE317
ATHR319
AARG325
AGLY329
ALYS330
ASER354
ASER363

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV, ECO:0007744|PDB:2Y0M
ChainResidueDetails
AARG326
AGLY327

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0007744|PDB:2Y0M
ChainResidueDetails
ATYR408
ALYS432

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:27382063, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV
ChainResidueDetails
AARG274

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER348

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1mj9
ChainResidueDetails
AGLU350
ACYS316

223790

PDB entries from 2024-08-14

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