2PO1
Crystal structure of the P. abyssi exosome RNase PH ring complexed with a single stranded 10-mer poly(A) RNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000177 | cellular_component | cytoplasmic exosome (RNase complex) |
| A | 0000178 | cellular_component | exosome (RNase complex) |
| A | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0010467 | biological_process | gene expression |
| A | 0016075 | biological_process | rRNA catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016896 | molecular_function | RNA exonuclease activity, producing 5'-phosphomonoesters |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0000177 | cellular_component | cytoplasmic exosome (RNase complex) |
| B | 0000178 | cellular_component | exosome (RNase complex) |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0016075 | biological_process | rRNA catabolic process |
| B | 0035925 | molecular_function | mRNA 3'-UTR AU-rich region binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD A 250 |
| Chain | Residue |
| A | ASP180 |
| A | GLY183 |
| A | GLU184 |
| A | ALA185 |
| A | ASP204 |
| A | HOH294 |
| B | GLU116 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 280 |
| Chain | Residue |
| B | GLU227 |
| B | LEU266 |
| B | HOH356 |
| B | GLU190 |
| B | LYS191 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 281 |
| Chain | Residue |
| B | PHE30 |
| B | LEU205 |
| B | TYR249 |
| B | HOH405 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 282 |
| Chain | Residue |
| A | TYR24 |
| A | LEU26 |
| B | LYS256 |
| B | HOH377 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD A 283 |
| Chain | Residue |
| A | TYR44 |
| B | LEU51 |
| B | LYS53 |
| B | GLN58 |
