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2PO1

Crystal structure of the P. abyssi exosome RNase PH ring complexed with a single stranded 10-mer poly(A) RNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000177cellular_componentcytoplasmic exosome (RNase complex)
A0000178cellular_componentexosome (RNase complex)
A0004527molecular_functionexonuclease activity
A0005737cellular_componentcytoplasm
A0006401biological_processRNA catabolic process
A0016075biological_processrRNA catabolic process
A0016896molecular_functionRNA exonuclease activity, producing 5'-phosphomonoesters
A0034475biological_processU4 snRNA 3'-end processing
A0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
B0000177cellular_componentcytoplasmic exosome (RNase complex)
B0000178cellular_componentexosome (RNase complex)
B0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0005737cellular_componentcytoplasm
B0006401biological_processRNA catabolic process
B0016075biological_processrRNA catabolic process
B0034473biological_processU1 snRNA 3'-end processing
B0034475biological_processU4 snRNA 3'-end processing
B0034476biological_processU5 snRNA 3'-end processing
B0071042biological_processnuclear polyadenylation-dependent mRNA catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MPD A 250
ChainResidue
AASP180
AGLY183
AGLU184
AALA185
AASP204
AHOH294
BGLU116

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MPD B 280
ChainResidue
BGLU227
BLEU266
BHOH356
BGLU190
BLYS191

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MPD B 281
ChainResidue
BPHE30
BLEU205
BTYR249
BHOH405

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MPD B 282
ChainResidue
ATYR24
ALEU26
BLYS256
BHOH377

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MPD A 283
ChainResidue
ATYR44
BLEU51
BLYS53
BGLN58

220113

PDB entries from 2024-05-22

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