2PNY
Structure of Human Isopentenyl-diphosphate Delta-isomerase 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004452 | molecular_function | isopentenyl-diphosphate delta-isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006695 | biological_process | cholesterol biosynthetic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0009240 | biological_process | isopentenyl diphosphate biosynthetic process |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016860 | molecular_function | intramolecular oxidoreductase activity |
| A | 0046490 | biological_process | isopentenyl diphosphate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 228 |
| Chain | Residue |
| A | SER86 |
| A | GLU115 |
| A | POP230 |
| A | HOH270 |
| A | HOH414 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 229 |
| Chain | Residue |
| A | GLU148 |
| A | HIS40 |
| A | HIS51 |
| A | HIS88 |
| A | GLU146 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE POP A 230 |
| Chain | Residue |
| A | ARG16 |
| A | LYS36 |
| A | ARG70 |
| A | LYS74 |
| A | THR76 |
| A | SER86 |
| A | SER87 |
| A | HIS88 |
| A | ARG111 |
| A | GLU115 |
| A | CA228 |
| A | HOH241 |
| A | HOH274 |
| A | HOH297 |
| A | HOH372 |
| A | HOH375 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 231 |
| Chain | Residue |
| A | ARG203 |
| A | LYS223 |
| A | HIS225 |
| A | ARG226 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 232 |
| Chain | Residue |
| A | ARG-2 |
| A | ARG37 |
| A | LEU41 |
| A | GLU43 |
| A | GLN69 |
| A | LYS169 |
| A | HOH261 |
| A | HOH303 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 233 |
| Chain | Residue |
| A | HIS135 |
| A | ARG226 |
| A | VAL227 |
| A | HOH419 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 150 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Microbody targeting signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
