Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2PNO

Crystal structure of human leukotriene C4 synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005640	cellular_component	nuclear outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0008047	molecular_function	enzyme activator activity
A	0008289	molecular_function	lipid binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019370	biological_process	leukotriene biosynthetic process
A	0031965	cellular_component	nuclear membrane
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0098869	biological_process	cellular oxidant detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005640	cellular_component	nuclear outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006691	biological_process	leukotriene metabolic process
B	0008047	molecular_function	enzyme activator activity
B	0008289	molecular_function	lipid binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0019370	biological_process	leukotriene biosynthetic process
B	0031965	cellular_component	nuclear membrane
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0098869	biological_process	cellular oxidant detoxification
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005640	cellular_component	nuclear outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006691	biological_process	leukotriene metabolic process
C	0008047	molecular_function	enzyme activator activity
C	0008289	molecular_function	lipid binding
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0019370	biological_process	leukotriene biosynthetic process
C	0031965	cellular_component	nuclear membrane
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0098869	biological_process	cellular oxidant detoxification
D	0004364	molecular_function	glutathione transferase activity
D	0004464	molecular_function	leukotriene-C4 synthase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005640	cellular_component	nuclear outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0006691	biological_process	leukotriene metabolic process
D	0008047	molecular_function	enzyme activator activity
D	0008289	molecular_function	lipid binding
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0019370	biological_process	leukotriene biosynthetic process
D	0031965	cellular_component	nuclear membrane
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0098869	biological_process	cellular oxidant detoxification
E	0004364	molecular_function	glutathione transferase activity
E	0004464	molecular_function	leukotriene-C4 synthase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005640	cellular_component	nuclear outer membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006629	biological_process	lipid metabolic process
E	0006691	biological_process	leukotriene metabolic process
E	0008047	molecular_function	enzyme activator activity
E	0008289	molecular_function	lipid binding
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0019370	biological_process	leukotriene biosynthetic process
E	0031965	cellular_component	nuclear membrane
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0098869	biological_process	cellular oxidant detoxification
F	0004364	molecular_function	glutathione transferase activity
F	0004464	molecular_function	leukotriene-C4 synthase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005640	cellular_component	nuclear outer membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006629	biological_process	lipid metabolic process
F	0006691	biological_process	leukotriene metabolic process
F	0008047	molecular_function	enzyme activator activity
F	0008289	molecular_function	lipid binding
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0019370	biological_process	leukotriene biosynthetic process
F	0031965	cellular_component	nuclear membrane
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0098869	biological_process	cellular oxidant detoxification
G	0004364	molecular_function	glutathione transferase activity
G	0004464	molecular_function	leukotriene-C4 synthase activity
G	0004602	molecular_function	glutathione peroxidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005640	cellular_component	nuclear outer membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006629	biological_process	lipid metabolic process
G	0006691	biological_process	leukotriene metabolic process
G	0008047	molecular_function	enzyme activator activity
G	0008289	molecular_function	lipid binding
G	0016020	cellular_component	membrane
G	0016740	molecular_function	transferase activity
G	0016829	molecular_function	lyase activity
G	0019370	biological_process	leukotriene biosynthetic process
G	0031965	cellular_component	nuclear membrane
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0098869	biological_process	cellular oxidant detoxification
H	0004364	molecular_function	glutathione transferase activity
H	0004464	molecular_function	leukotriene-C4 synthase activity
H	0004602	molecular_function	glutathione peroxidase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005635	cellular_component	nuclear envelope
H	0005640	cellular_component	nuclear outer membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006629	biological_process	lipid metabolic process
H	0006691	biological_process	leukotriene metabolic process
H	0008047	molecular_function	enzyme activator activity
H	0008289	molecular_function	lipid binding
H	0016020	cellular_component	membrane
H	0016740	molecular_function	transferase activity
H	0016829	molecular_function	lyase activity
H	0019370	biological_process	leukotriene biosynthetic process
H	0031965	cellular_component	nuclear membrane
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0098869	biological_process	cellular oxidant detoxification
I	0004364	molecular_function	glutathione transferase activity
I	0004464	molecular_function	leukotriene-C4 synthase activity
I	0004602	molecular_function	glutathione peroxidase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005635	cellular_component	nuclear envelope
I	0005640	cellular_component	nuclear outer membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0006629	biological_process	lipid metabolic process
I	0006691	biological_process	leukotriene metabolic process
I	0008047	molecular_function	enzyme activator activity
I	0008289	molecular_function	lipid binding
I	0016020	cellular_component	membrane
I	0016740	molecular_function	transferase activity
I	0016829	molecular_function	lyase activity
I	0019370	biological_process	leukotriene biosynthetic process
I	0031965	cellular_component	nuclear membrane
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0042802	molecular_function	identical protein binding
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0098869	biological_process	cellular oxidant detoxification
J	0004364	molecular_function	glutathione transferase activity
J	0004464	molecular_function	leukotriene-C4 synthase activity
J	0004602	molecular_function	glutathione peroxidase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005635	cellular_component	nuclear envelope
J	0005640	cellular_component	nuclear outer membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0006629	biological_process	lipid metabolic process
J	0006691	biological_process	leukotriene metabolic process
J	0008047	molecular_function	enzyme activator activity
J	0008289	molecular_function	lipid binding
J	0016020	cellular_component	membrane
J	0016740	molecular_function	transferase activity
J	0016829	molecular_function	lyase activity
J	0019370	biological_process	leukotriene biosynthetic process
J	0031965	cellular_component	nuclear membrane
J	0042759	biological_process	long-chain fatty acid biosynthetic process
J	0042802	molecular_function	identical protein binding
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0098869	biological_process	cellular oxidant detoxification
K	0004364	molecular_function	glutathione transferase activity
K	0004464	molecular_function	leukotriene-C4 synthase activity
K	0004602	molecular_function	glutathione peroxidase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005635	cellular_component	nuclear envelope
K	0005640	cellular_component	nuclear outer membrane
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0006629	biological_process	lipid metabolic process
K	0006691	biological_process	leukotriene metabolic process
K	0008047	molecular_function	enzyme activator activity
K	0008289	molecular_function	lipid binding
K	0016020	cellular_component	membrane
K	0016740	molecular_function	transferase activity
K	0016829	molecular_function	lyase activity
K	0019370	biological_process	leukotriene biosynthetic process
K	0031965	cellular_component	nuclear membrane
K	0042759	biological_process	long-chain fatty acid biosynthetic process
K	0042802	molecular_function	identical protein binding
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0098869	biological_process	cellular oxidant detoxification
L	0004364	molecular_function	glutathione transferase activity
L	0004464	molecular_function	leukotriene-C4 synthase activity
L	0004602	molecular_function	glutathione peroxidase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005635	cellular_component	nuclear envelope
L	0005640	cellular_component	nuclear outer membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0006629	biological_process	lipid metabolic process
L	0006691	biological_process	leukotriene metabolic process
L	0008047	molecular_function	enzyme activator activity
L	0008289	molecular_function	lipid binding
L	0016020	cellular_component	membrane
L	0016740	molecular_function	transferase activity
L	0016829	molecular_function	lyase activity
L	0019370	biological_process	leukotriene biosynthetic process
L	0031965	cellular_component	nuclear membrane
L	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0042802	molecular_function	identical protein binding
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH A 201

Chain	Residue
A	ARG51
B	VAL26
B	ILE27
B	ARG30
B	PRO37
B	TYR50
B	GLN53
A	ASN55
A	GLU58
A	TYR59
A	TYR93
A	TYR97
A	ARG104
A	LEU108
B	SER23

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH B 202

Chain	Residue
B	ARG51
B	ASN55
B	GLU58
B	TYR59
B	TYR93
B	TYR97
B	ARG104
B	LEU108
C	SER23
C	VAL26
C	ILE27
C	ARG30
C	PRO37
C	TYR50
C	GLN53

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GSH C 203

Chain	Residue
A	SER23
A	VAL26
A	ILE27
A	ARG30
A	PRO37
A	TYR50
A	GLN53
C	ARG51
C	ASN55
C	GLU58
C	TYR59
C	TYR93
C	TYR97
C	ARG104
C	LEU108
C	LMT216

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH D 204

Chain	Residue
D	ARG51
D	ASN55
D	GLU58
D	TYR59
D	TYR93
D	TYR97
D	ARG104
D	LEU108
E	SER23
E	VAL26
E	ILE27
E	ARG30
E	PRO37
E	TYR50
E	GLN53

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH E 205

Chain	Residue
E	ARG51
E	ASN55
E	GLU58
E	TYR59
E	TYR93
E	TYR97
E	ARG104
E	LEU108
F	SER23
F	VAL26
F	ILE27
F	ARG30
F	PRO37
F	TYR50
F	GLN53

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH F 206

Chain	Residue
D	SER23
D	VAL26
D	ILE27
D	ARG30
D	PRO37
D	TYR50
D	GLN53
F	ARG51
F	ASN55
F	GLU58
F	TYR59
F	TYR93
F	TYR97
F	ARG104
F	LEU108

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GSH G 207

Chain	Residue
H	SER23
H	ILE27
H	ARG30
H	PRO37
H	TYR50
H	GLN53
G	ARG51
G	ASN55
G	GLU58
G	TYR59
G	TYR93
G	TYR97
G	ARG104
G	LEU108

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH H 208

Chain	Residue
H	ARG51
H	ASN55
H	GLU58
H	TYR59
H	TYR93
H	TYR97
H	ARG104
H	LEU108
I	SER23
I	VAL26
I	ILE27
I	ARG30
I	PRO37
I	TYR50
I	GLN53

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GSH I 209

Chain	Residue
G	SER23
G	VAL26
G	ILE27
G	ARG30
G	TYR50
G	GLN53
I	ARG51
I	ASN55
I	GLU58
I	TYR59
I	TYR93
I	TYR97
I	ARG104
I	LEU108

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH J 210

Chain	Residue
J	ARG51
J	ASN55
J	GLU58
J	TYR59
J	TYR93
J	TYR97
J	ARG104
J	LEU108
K	SER23
K	VAL26
K	ILE27
K	ARG30
K	PRO37
K	TYR50
K	GLN53

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH K 211

Chain	Residue
K	ARG51
K	ASN55
K	GLU58
K	TYR59
K	TYR93
K	TYR97
K	ARG104
K	LEU108
L	SER23
L	VAL26
L	ILE27
L	ARG30
L	PRO37
L	TYR50
L	GLN53

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH L 212

Chain	Residue
J	SER23
J	VAL26
J	ILE27
J	ARG30
J	PRO37
J	TYR50
J	GLN53
L	ARG51
L	ASN55
L	GLU58
L	TYR59
L	TYR93
L	TYR97
L	ARG104
L	LEU108

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 213

Chain	Residue
B	LMT218
C	LEU24

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT C 214

Chain	Residue
C	TYR21
C	GLN95

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT A 215

Chain	Residue
A	TYR21
A	GLN25

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LMT C 216

Chain	Residue
A	ALA20
A	ILE27
C	TYR59
C	ARG104
C	LEU105
C	TYR109
C	LEU115
C	TRP116
C	GSH203

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT A 217

Chain	Residue
A	TYR59
A	TRP116

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LMT B 218

Chain	Residue
B	TYR59
B	TYR109
B	ARG113
B	TRP116
B	LMT213
C	ALA20

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT F 219

Chain	Residue
F	TYR59
F	LEU108
F	ALA112
F	TRP116

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT D 220

Chain	Residue
D	TYR59
D	ALA112
D	TRP116
E	ALA20
E	ILE27

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT E 221

Chain	Residue
E	TYR59
E	LEU115
E	TRP116
F	ALA20

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT G 222

Chain	Residue
G	TYR59
G	TYR109
G	LEU115
G	TRP116
H	ALA20

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT L 223

Chain	Residue
J	ILE27
L	TYR59
L	LEU115
L	TRP116

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT K 224

Chain	Residue
K	TYR59
K	TRP116

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT K 225

Chain	Residue
K	HIS129
K	PHE130
L	ASP3

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT L 226

Chain	Residue
L	LEU81

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT B 227

Chain	Residue
B	PHE130

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT A 228

Chain	Residue
A	HIS75

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT E 230

Chain	Residue
D	PHE130
E	GLU76
E	LMT231

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT E 231

Chain	Residue
E	HIS75
E	LMT230
E	LMT269

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT E 232

Chain	Residue
E	PHE130

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT F 233

Chain	Residue
F	PHE130

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT G 235

Chain	Residue
G	PHE73
G	PHE74

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 236

Chain	Residue
B	ALA128
B	ARG136

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT C 237

Chain	Residue
A	LYS2
C	PHE73
C	PHE74
D	PRO132
D	LMT238

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT D 238

Chain	Residue
C	LMT237
D	GLU4
D	PHE73
D	PHE74
E	LYS2

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LMT J 239

Chain	Residue
J	LYS2
J	LYS2
J	ASP3
L	PHE73
L	ALA128
L	ALA128
L	HIS129

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT I 240

Chain	Residue
I	ARG136
K	PHE74
K	ALA128

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT F 241

Chain	Residue
F	ALA128
F	PRO132
F	ALA133
F	ARG136

site_id	EC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT B 242

Chain	Residue
B	HIS75

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT E 243

Chain	Residue
D	TRP116
E	LEU24
E	GLN25
E	LMT268

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT A 244

Chain	Residue
A	ILE72
A	LMT245
B	TRP68
C	LMT246

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT A 245

Chain	Residue
A	TRP68
A	LMT244
C	ILE72

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT C 246

Chain	Residue
A	LMT244
B	TRP68
C	TRP68

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT D 247

Chain	Residue
D	LYS2
D	TRP68
F	ILE72
F	LMT248

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT F 248

Chain	Residue
D	LMT247
E	ILE72
E	LMT249
F	TRP68

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT E 249

Chain	Residue
D	ILE72
E	TRP68
F	LMT248

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT H 250

Chain	Residue
G	ILE72
H	TRP68
I	LMT252

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT G 251

Chain	Residue
G	TRP68
I	ILE72

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT I 252

Chain	Residue
H	ALA65
H	TRP68
H	ILE72
H	LMT250
I	TRP68

site_id	FC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT J 253

Chain	Residue
J	TRP68
K	TRP68
L	LMT254

site_id	FC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT L 254

Chain	Residue
J	TRP68
J	LMT253
L	ILE72

site_id	FC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT L 255

Chain	Residue
K	ILE72
L	TRP68

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT A 256

Chain	Residue
A	PRO132
A	ARG136
E	PHE74
E	ALA128

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT I 257

Chain	Residue
I	LEU18
I	TYR21
I	GLN95

site_id	GC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT I 258

Chain	Residue
I	ALA128
K	LEU135
K	ARG136

site_id	GC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT C 261

Chain	Residue
C	PHE130

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT A 262

Chain	Residue
A	ARG92

site_id	GC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT E 263

Chain	Residue
A	PHE73
E	PRO132
E	ARG136

site_id	GC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT G 264

Chain	Residue
G	GLN95

site_id	GC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT L 265

Chain	Residue
L	TYR21

site_id	GC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT E 266

Chain	Residue
E	LMT269

site_id	GC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT G 267

Chain	Residue
G	PHE130

site_id	HC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT E 268

Chain	Residue
E	GLN95
E	ARG99
E	LMT243

site_id	HC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT E 269

Chain	Residue
E	LMT231
E	LMT266

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GppeFERVYrAQvNC

Chain	Residue	Details
A	GLY42-CYS56

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	396
Details	TOPO_DOM: Cytoplasmic => ECO:0000305\|PubMed:12023288, ECO:0000305\|PubMed:17632546, ECO:0000305\|PubMed:17632548

Chain	Residue	Details
A	MET1-ALA6
D	MET1-ALA6
D	ALA70-PHE73
D	GLY125-ALA150
E	MET1-ALA6
E	ALA70-PHE73
E	GLY125-ALA150
F	MET1-ALA6
F	ALA70-PHE73
F	GLY125-ALA150
G	MET1-ALA6
A	ALA70-PHE73
G	ALA70-PHE73
G	GLY125-ALA150
H	MET1-ALA6
H	ALA70-PHE73
H	GLY125-ALA150
I	MET1-ALA6
I	ALA70-PHE73
I	GLY125-ALA150
J	MET1-ALA6
J	ALA70-PHE73
A	GLY125-ALA150
J	GLY125-ALA150
K	MET1-ALA6
K	ALA70-PHE73
K	GLY125-ALA150
L	MET1-ALA6
L	ALA70-PHE73
L	GLY125-ALA150
B	MET1-ALA6
B	ALA70-PHE73
B	GLY125-ALA150
C	MET1-ALA6
C	ALA70-PHE73
C	GLY125-ALA150

site_id	SWS_FT_FI2
Number of Residues	948
Details	TRANSMEM: Helical => ECO:0000305\|PubMed:12023288, ECO:0000305\|PubMed:17632546, ECO:0000305\|PubMed:17632548

Chain	Residue	Details
A	LEU7-ILE27
C	VAL49-VAL69
C	PHE74-PHE94
C	LEU105-LEU124
D	LEU7-ILE27
D	VAL49-VAL69
D	PHE74-PHE94
D	LEU105-LEU124
E	LEU7-ILE27
E	VAL49-VAL69
E	PHE74-PHE94
A	VAL49-VAL69
E	LEU105-LEU124
F	LEU7-ILE27
F	VAL49-VAL69
F	PHE74-PHE94
F	LEU105-LEU124
G	LEU7-ILE27
G	VAL49-VAL69
G	PHE74-PHE94
G	LEU105-LEU124
H	LEU7-ILE27
A	PHE74-PHE94
H	VAL49-VAL69
H	PHE74-PHE94
H	LEU105-LEU124
I	LEU7-ILE27
I	VAL49-VAL69
I	PHE74-PHE94
I	LEU105-LEU124
J	LEU7-ILE27
J	VAL49-VAL69
J	PHE74-PHE94
A	LEU105-LEU124
J	LEU105-LEU124
K	LEU7-ILE27
K	VAL49-VAL69
K	PHE74-PHE94
K	LEU105-LEU124
L	LEU7-ILE27
L	VAL49-VAL69
L	PHE74-PHE94
L	LEU105-LEU124
B	LEU7-ILE27
B	VAL49-VAL69
B	PHE74-PHE94
B	LEU105-LEU124
C	LEU7-ILE27

site_id	SWS_FT_FI3
Number of Residues	348
Details	TOPO_DOM: Lumenal => ECO:0000305\|PubMed:12023288, ECO:0000305\|PubMed:17632546, ECO:0000305\|PubMed:17632548

Chain	Residue	Details
A	SER28-ARG48
E	GLN95-ARG104
F	SER28-ARG48
F	GLN95-ARG104
G	SER28-ARG48
G	GLN95-ARG104
H	SER28-ARG48
H	GLN95-ARG104
I	SER28-ARG48
I	GLN95-ARG104
J	SER28-ARG48
A	GLN95-ARG104
J	GLN95-ARG104
K	SER28-ARG48
K	GLN95-ARG104
L	SER28-ARG48
L	GLN95-ARG104
B	SER28-ARG48
B	GLN95-ARG104
C	SER28-ARG48
C	GLN95-ARG104
D	SER28-ARG48
D	GLN95-ARG104
E	SER28-ARG48

site_id	SWS_FT_FI4
Number of Residues	12
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:17632548

Chain	Residue	Details
A	ARG31
J	ARG31
K	ARG31
L	ARG31
B	ARG31
C	ARG31
D	ARG31
E	ARG31
F	ARG31
G	ARG31
H	ARG31
I	ARG31

site_id	SWS_FT_FI5
Number of Residues	12
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:17632548

Chain	Residue	Details
A	ARG104
J	ARG104
K	ARG104
L	ARG104
B	ARG104
C	ARG104
D	ARG104
E	ARG104
F	ARG104
G	ARG104
H	ARG104
I	ARG104

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:17632546, ECO:0000269\|PubMed:17632548, ECO:0000269\|PubMed:27365393

Chain	Residue	Details
A	ARG30
J	ARG30
K	ARG30
L	ARG30
B	ARG30
C	ARG30
D	ARG30
E	ARG30
F	ARG30
G	ARG30
H	ARG30
I	ARG30

site_id	SWS_FT_FI7
Number of Residues	36
Details	BINDING: BINDING => ECO:0000305\|PubMed:17632548

Chain	Residue	Details
A	ARG51
D	ARG51
D	GLU58
D	TYR93
E	ARG51
E	GLU58
E	TYR93
F	ARG51
F	GLU58
F	TYR93
G	ARG51
A	GLU58
G	GLU58
G	TYR93
H	ARG51
H	GLU58
H	TYR93
I	ARG51
I	GLU58
I	TYR93
J	ARG51
J	GLU58
A	TYR93
J	TYR93
K	ARG51
K	GLU58
K	TYR93
L	ARG51
L	GLU58
L	TYR93
B	ARG51
B	GLU58
B	TYR93
C	ARG51
C	GLU58
C	TYR93

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphoserine; by RPS6KB1 => ECO:0000269\|PubMed:27365393

Chain	Residue	Details
A	SER36
J	SER36
K	SER36
L	SER36
B	SER36
C	SER36
D	SER36
E	SER36
F	SER36
G	SER36
H	SER36
I	SER36

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)