2PNF
Structure of Aquifex Aeolicus FabG 3-oxoacyl-(acyl-carrier protein) reductase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0032787 | biological_process | monocarboxylic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0032787 | biological_process | monocarboxylic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE A 401 |
| Chain | Residue |
| A | LYS4 |
| A | LEU5 |
| A | GLN6 |
| A | GLY7 |
| A | LYS8 |
| A | TRP136 |
| A | GLU231 |
| A | HOH1190 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PE B 501 |
| Chain | Residue |
| B | GLY7 |
| B | LYS8 |
| B | TRP136 |
| B | GLU231 |
| B | HOH1108 |
| B | LYS4 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE B 601 |
| Chain | Residue |
| B | GLN154 |
| B | TYR157 |
| B | ILE190 |
| B | THR195 |
| B | TYR206 |
| B | PHE215 |
| B | HOH1287 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE A 701 |
| Chain | Residue |
| A | GLN154 |
| A | TYR157 |
| A | PHE189 |
| A | ILE190 |
| A | THR195 |
| A | TYR206 |
| A | PHE215 |
| A | HOH1188 |
| A | HOH1244 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES B 801 |
| Chain | Residue |
| A | ASP98 |
| A | LYS99 |
| A | ASP108 |
| A | GLN125 |
| A | HOH1264 |
| B | LEU102 |
| B | ARG103 |
| B | SER105 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgftgnvgQvnYSTTKAGLiGFTkSLA |
| Chain | Residue | Details |
| A | SER144-ALA172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| A | LYS161 | |
| A | ASN116 | |
| A | SER144 | |
| A | TYR157 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| B | LYS161 | |
| B | ASN116 | |
| B | SER144 | |
| B | TYR157 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| A | GLN154 | |
| A | LYS161 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| B | GLN154 | |
| B | LYS161 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| A | LYS161 | |
| A | TYR157 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ybv |
| Chain | Residue | Details |
| B | LYS161 | |
| B | TYR157 |
