2PMP

Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from the isoprenoid biosynthetic pathway of Arabidopsis thaliana

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 500

Chain	Residue
A	ASP11
A	HIS13
A	HIS45
A	HOH704

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 701

Chain	Residue
A	HOH749
A	HOH757
A	HOH757
A	ASP141
A	ASP141
A	LEU143
A	HOH749
A	HOH749

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 702

Chain	Residue
A	GLN104
A	ARG105

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE C5P A 700

Chain	Residue
A	ASP59
A	ILE60
A	GLY61
A	LEU103
A	PRO106
A	LYS107
A	ILE108
A	SER109
A	ALA134
A	LYS135
A	THR136
A	HOH748
A	HOH765
A	HOH766

---

Functional Information from PROSITE/UniProt

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDVLlHCvvDAilG

Chain	Residue	Details
A	SER38-GLY53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62617","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"2PMP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17660251","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PMP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P62617","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---