2PLA

Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002027	biological_process	regulation of heart rate
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006072	biological_process	glycerol-3-phosphate metabolic process
A	0010765	biological_process	positive regulation of sodium ion transport
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0017080	molecular_function	sodium channel regulator activity
A	0019674	biological_process	NAD+ metabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0044325	molecular_function	transmembrane transporter binding
A	0046168	biological_process	glycerol-3-phosphate catabolic process
A	0047952	molecular_function	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A	0051287	molecular_function	NAD binding
A	0060373	biological_process	regulation of ventricular cardiac muscle cell membrane depolarization
A	0070062	cellular_component	extracellular exosome
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	2000010	biological_process	positive regulation of protein localization to cell surface
B	0002027	biological_process	regulation of heart rate
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0006072	biological_process	glycerol-3-phosphate metabolic process
B	0010765	biological_process	positive regulation of sodium ion transport
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0017080	molecular_function	sodium channel regulator activity
B	0019674	biological_process	NAD+ metabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0044325	molecular_function	transmembrane transporter binding
B	0046168	biological_process	glycerol-3-phosphate catabolic process
B	0047952	molecular_function	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B	0051287	molecular_function	NAD binding
B	0060373	biological_process	regulation of ventricular cardiac muscle cell membrane depolarization
B	0070062	cellular_component	extracellular exosome
B	0086005	biological_process	ventricular cardiac muscle cell action potential
B	2000010	biological_process	positive regulation of protein localization to cell surface

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	LYS206
A	ASN207
A	THR266
A	GLY270
A	ARG271
A	ASN272
A	HOH507
A	HOH566

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 B 502

Chain	Residue
B	ASN207
B	THR266
B	GLY270
B	ARG271
B	ASN272
B	HOH602
B	HOH604
B	HOH610
B	HOH643
B	LYS206

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 503

Chain	Residue
A	LYS22
A	HIS69
A	LYS70
A	LYS320

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 601

Chain	Residue
B	LYS22
B	LYS70

---

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD A 401

Chain	Residue
A	GLY14
A	ASN15
A	TRP16
A	GLY17
A	PHE43
A	TYR65
A	PHE99
A	ARG102
A	ILE121
A	LYS122
A	ASN153
A	ALA155
A	ARG271
A	GLY296
A	GLN297
A	LYS298
A	HOH506
A	HOH566
A	HOH567
A	HOH574
A	HOH575
A	HOH576
A	HOH582
A	HOH588

---

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD B 401

Chain	Residue
B	GLY14
B	ASN15
B	TRP16
B	GLY17
B	PHE43
B	TYR65
B	VAL94
B	PRO96
B	PHE99
B	LEU120
B	ILE121
B	LYS122
B	ASN153
B	ILE154
B	ALA155
B	ARG271
B	GLY296
B	GLN297
B	LYS298
B	GLN300
B	HOH604
B	HOH610
B	HOH619
B	HOH643

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1evy

Chain	Residue	Details
A	THR266
A	LYS206

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1evy

Chain	Residue	Details
B	THR266
B	LYS206

---