2PKR
Crystal structure of (A+CTE)4 chimeric form of photosyntetic glyceraldehyde-3-phosphate dehydrogenase, complexed with NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
| H | 0006006 | biological_process | glucose metabolic process |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0050661 | molecular_function | NADP binding |
| H | 0051287 | molecular_function | NAD binding |
| I | 0006006 | biological_process | glucose metabolic process |
| I | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| I | 0050661 | molecular_function | NADP binding |
| I | 0051287 | molecular_function | NAD binding |
| L | 0006006 | biological_process | glucose metabolic process |
| L | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| L | 0050661 | molecular_function | NADP binding |
| L | 0051287 | molecular_function | NAD binding |
| M | 0006006 | biological_process | glucose metabolic process |
| M | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| M | 0050661 | molecular_function | NADP binding |
| M | 0051287 | molecular_function | NAD binding |
| O | 0006006 | biological_process | glucose metabolic process |
| O | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| O | 0050661 | molecular_function | NADP binding |
| O | 0051287 | molecular_function | NAD binding |
| P | 0006006 | biological_process | glucose metabolic process |
| P | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| P | 0050661 | molecular_function | NADP binding |
| P | 0051287 | molecular_function | NAD binding |
| Q | 0006006 | biological_process | glucose metabolic process |
| Q | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| Q | 0050661 | molecular_function | NADP binding |
| Q | 0051287 | molecular_function | NAD binding |
| R | 0006006 | biological_process | glucose metabolic process |
| R | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| R | 0050661 | molecular_function | NADP binding |
| R | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 O 363 |
| Chain | Residue |
| O | THR179 |
| O | ASP181 |
| O | ARG195 |
| O | ARG231 |
| O | NDP372 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 O 364 |
| Chain | Residue |
| O | ALA210 |
| O | SER148 |
| O | THR150 |
| O | THR208 |
| O | GLY209 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 O 371 |
| Chain | Residue |
| O | PHE251 |
| O | ALA252 |
| O | GLU253 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 R 363 |
| Chain | Residue |
| R | THR179 |
| R | ASP181 |
| R | ARG195 |
| R | ARG231 |
| R | SO4364 |
| R | NDP377 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 R 364 |
| Chain | Residue |
| R | SER148 |
| R | CYS149 |
| R | THR150 |
| R | THR208 |
| R | SO4363 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 R 376 |
| Chain | Residue |
| R | PHE251 |
| R | ALA252 |
| R | VAL299 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 P 363 |
| Chain | Residue |
| P | THR179 |
| P | ASP181 |
| P | ARG195 |
| P | ARG231 |
| P | SO4364 |
| P | NDP373 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 P 364 |
| Chain | Residue |
| P | SER148 |
| P | CYS149 |
| P | THR150 |
| P | HIS176 |
| P | THR208 |
| P | GLY209 |
| P | SO4363 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 P 372 |
| Chain | Residue |
| P | GLU253 |
| P | ASN256 |
| P | ARG260 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 Q 363 |
| Chain | Residue |
| Q | THR179 |
| Q | ASP181 |
| Q | ARG195 |
| Q | ARG231 |
| Q | SO4364 |
| Q | NDP375 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 Q 364 |
| Chain | Residue |
| Q | SER148 |
| Q | CYS149 |
| Q | THR150 |
| Q | HIS176 |
| Q | THR208 |
| Q | ARG231 |
| Q | SO4363 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 Q 373 |
| Chain | Residue |
| O | GLU276 |
| Q | SER41 |
| Q | HIS42 |
| Q | LYS45 |
| Q | TYR46 |
| Q | VAL57 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 Q 374 |
| Chain | Residue |
| Q | SER62 |
| Q | LYS72 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 363 |
| Chain | Residue |
| A | THR179 |
| A | ASP181 |
| A | ARG195 |
| A | ARG231 |
| A | NDP376 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 364 |
| Chain | Residue |
| A | SER148 |
| A | CYS149 |
| A | THR150 |
| A | HIS176 |
| A | THR208 |
| A | GLY209 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 375 |
| Chain | Residue |
| A | GLU253 |
| A | ASN256 |
| A | ARG260 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 363 |
| Chain | Residue |
| B | THR179 |
| B | ASP181 |
| B | ARG195 |
| B | ARG231 |
| B | NDP378 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 364 |
| Chain | Residue |
| B | SER148 |
| B | CYS149 |
| B | THR150 |
| B | HIS176 |
| B | THR208 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 377 |
| Chain | Residue |
| B | SER41 |
| B | HIS42 |
| B | VAL57 |
| C | GLU276 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 363 |
| Chain | Residue |
| C | THR179 |
| C | ASP181 |
| C | ARG195 |
| C | NDP365 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 364 |
| Chain | Residue |
| C | GLY209 |
| C | ALA210 |
| C | SER148 |
| C | THR150 |
| C | THR208 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 363 |
| Chain | Residue |
| D | THR179 |
| D | ASP181 |
| D | ARG195 |
| D | ARG231 |
| D | NDP365 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 364 |
| Chain | Residue |
| D | SER148 |
| D | THR150 |
| D | THR208 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 363 |
| Chain | Residue |
| H | THR179 |
| H | ASP181 |
| H | ARG195 |
| H | ARG231 |
| H | NDP379 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 364 |
| Chain | Residue |
| H | SER148 |
| H | CYS149 |
| H | THR150 |
| H | HIS176 |
| H | THR208 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 378 |
| Chain | Residue |
| H | PHE251 |
| H | ALA252 |
| H | GLU253 |
| H | VAL299 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 I 365 |
| Chain | Residue |
| I | THR179 |
| I | ASP181 |
| I | ARG195 |
| I | ARG231 |
| I | NDP380 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 I 366 |
| Chain | Residue |
| I | SER148 |
| I | THR208 |
| I | GLY209 |
| I | ALA210 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 I 379 |
| Chain | Residue |
| I | GLU253 |
| I | ASN256 |
| I | ARG260 |
| I | SER294 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 L 367 |
| Chain | Residue |
| L | THR179 |
| L | ASP181 |
| L | ARG195 |
| L | ARG231 |
| L | NDP369 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 L 368 |
| Chain | Residue |
| L | SER148 |
| L | THR150 |
| L | HIS176 |
| L | THR208 |
| L | GLY209 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 M 369 |
| Chain | Residue |
| M | THR179 |
| M | ASP181 |
| M | ARG195 |
| M | ARG231 |
| M | NDP381 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 M 370 |
| Chain | Residue |
| M | SER148 |
| M | CYS149 |
| M | THR150 |
| M | THR208 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 M 380 |
| Chain | Residue |
| M | SER62 |
| M | LYS72 |
| site_id | DC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NDP O 372 |
| Chain | Residue |
| O | PHE8 |
| O | GLY9 |
| O | ARG10 |
| O | ILE11 |
| O | ASN31 |
| O | ASP76 |
| O | ARG77 |
| O | GLY95 |
| O | THR96 |
| O | GLY97 |
| O | VAL98 |
| O | PHE99 |
| O | THR119 |
| O | ALA120 |
| O | ASN313 |
| O | GLU314 |
| O | TYR317 |
| O | SO4363 |
| R | ARG183 |
| R | SER188 |
| site_id | DC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP R 377 |
| Chain | Residue |
| O | ARG183 |
| O | SER188 |
| R | PHE8 |
| R | GLY9 |
| R | ARG10 |
| R | ILE11 |
| R | ASN31 |
| R | THR33 |
| R | ASP76 |
| R | ARG77 |
| R | GLY95 |
| R | THR96 |
| R | GLY97 |
| R | VAL98 |
| R | PHE99 |
| R | THR119 |
| R | ALA120 |
| R | ASN313 |
| R | GLU314 |
| R | TYR317 |
| R | SO4363 |
| site_id | EC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP P 373 |
| Chain | Residue |
| P | PHE8 |
| P | GLY9 |
| P | ARG10 |
| P | ILE11 |
| P | ASN31 |
| P | ASP76 |
| P | ARG77 |
| P | GLY95 |
| P | THR96 |
| P | GLY97 |
| P | PHE99 |
| P | THR119 |
| P | ALA120 |
| P | ASN313 |
| P | GLU314 |
| P | TYR317 |
| P | SO4363 |
| Q | ARG183 |
| Q | SER188 |
| site_id | EC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NDP Q 375 |
| Chain | Residue |
| P | ARG183 |
| P | SER188 |
| Q | GLY7 |
| Q | PHE8 |
| Q | GLY9 |
| Q | ARG10 |
| Q | ILE11 |
| Q | ASN31 |
| Q | THR33 |
| Q | ASP76 |
| Q | ARG77 |
| Q | GLY95 |
| Q | THR96 |
| Q | GLY97 |
| Q | VAL98 |
| Q | PHE99 |
| Q | THR119 |
| Q | ALA120 |
| Q | CYS149 |
| Q | ASN313 |
| Q | TYR317 |
| Q | SO4363 |
| site_id | EC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP A 376 |
| Chain | Residue |
| A | GLY7 |
| A | PHE8 |
| A | GLY9 |
| A | ARG10 |
| A | ILE11 |
| A | ASN31 |
| A | ASP76 |
| A | ARG77 |
| A | GLY95 |
| A | THR96 |
| A | GLY97 |
| A | PHE99 |
| A | THR119 |
| A | ALA120 |
| A | ASN313 |
| A | GLU314 |
| A | TYR317 |
| A | SO4363 |
| B | SER188 |
| site_id | EC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP B 378 |
| Chain | Residue |
| A | SER188 |
| B | GLY7 |
| B | PHE8 |
| B | GLY9 |
| B | ARG10 |
| B | ILE11 |
| B | ASN31 |
| B | ASP76 |
| B | ARG77 |
| B | GLY95 |
| B | THR96 |
| B | GLY97 |
| B | VAL98 |
| B | PHE99 |
| B | THR119 |
| B | ALA120 |
| B | ASN313 |
| B | TYR317 |
| B | SO4363 |
| site_id | EC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NDP C 365 |
| Chain | Residue |
| C | PHE8 |
| C | GLY9 |
| C | ARG10 |
| C | ILE11 |
| C | ASN31 |
| C | ASP76 |
| C | ARG77 |
| C | GLY95 |
| C | THR96 |
| C | GLY97 |
| C | VAL98 |
| C | PHE99 |
| C | THR119 |
| C | ALA120 |
| C | ASN313 |
| C | GLU314 |
| C | TYR317 |
| C | SO4363 |
| D | ARG183 |
| D | SER188 |
| site_id | EC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP D 365 |
| Chain | Residue |
| C | ARG183 |
| C | SER188 |
| D | PHE8 |
| D | GLY9 |
| D | ARG10 |
| D | ILE11 |
| D | ASN31 |
| D | ASP76 |
| D | ARG77 |
| D | GLY95 |
| D | THR96 |
| D | GLY97 |
| D | VAL98 |
| D | PHE99 |
| D | THR119 |
| D | ALA120 |
| D | ASN313 |
| D | TYR317 |
| D | SO4363 |
| site_id | EC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP H 379 |
| Chain | Residue |
| H | PHE8 |
| H | GLY9 |
| H | ARG10 |
| H | ILE11 |
| H | ASN31 |
| H | ASP76 |
| H | ARG77 |
| H | GLY95 |
| H | THR96 |
| H | GLY97 |
| H | VAL98 |
| H | PHE99 |
| H | THR119 |
| H | ALA120 |
| H | CYS149 |
| H | ASN313 |
| H | TYR317 |
| H | SO4363 |
| I | SER188 |
| site_id | EC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NDP I 380 |
| Chain | Residue |
| H | ARG183 |
| H | SER188 |
| I | GLY7 |
| I | PHE8 |
| I | GLY9 |
| I | ARG10 |
| I | ILE11 |
| I | ASN31 |
| I | ASP76 |
| I | ARG77 |
| I | GLY95 |
| I | THR96 |
| I | GLY97 |
| I | VAL98 |
| I | PHE99 |
| I | THR119 |
| I | ALA120 |
| I | ASN313 |
| I | TYR317 |
| I | SO4365 |
| site_id | EC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP L 369 |
| Chain | Residue |
| L | GLY7 |
| L | PHE8 |
| L | GLY9 |
| L | ARG10 |
| L | ILE11 |
| L | ASN31 |
| L | ASP76 |
| L | ARG77 |
| L | GLY95 |
| L | THR96 |
| L | GLY97 |
| L | VAL98 |
| L | PHE99 |
| L | THR119 |
| L | ALA120 |
| L | CYS149 |
| L | ASN313 |
| L | TYR317 |
| L | SO4367 |
| M | ARG183 |
| M | SER188 |
| site_id | FC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP M 381 |
| Chain | Residue |
| L | SER188 |
| M | GLY7 |
| M | PHE8 |
| M | GLY9 |
| M | ARG10 |
| M | ILE11 |
| M | ASN31 |
| M | ASP76 |
| M | ARG77 |
| M | GLY95 |
| M | THR96 |
| M | GLY97 |
| M | VAL98 |
| M | PHE99 |
| M | THR119 |
| M | ALA120 |
| M | ASN313 |
| M | TYR317 |
| M | SO4369 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| O | ALA147-LEU154 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Nucleophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11846565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12705826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15236965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17573533","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Site: {"description":"Activates thiol group during catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| O | CYS149 | |
| O | HIS176 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| I | CYS149 | |
| I | HIS176 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| L | CYS149 | |
| L | HIS176 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| M | CYS149 | |
| M | HIS176 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| R | CYS149 | |
| R | HIS176 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| P | CYS149 | |
| P | HIS176 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| Q | CYS149 | |
| Q | HIS176 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| A | CYS149 | |
| A | HIS176 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| B | CYS149 | |
| B | HIS176 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| C | CYS149 | |
| C | HIS176 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| D | CYS149 | |
| D | HIS176 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| H | CYS149 | |
| H | HIS176 |
