Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2PKQ

Crystal structure of the photosynthetic A2B2-glyceraldehyde-3-phosphate dehydrogenase, complexed with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0006006	biological_process	glucose metabolic process
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0006006	biological_process	glucose metabolic process
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0006006	biological_process	glucose metabolic process
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0006006	biological_process	glucose metabolic process
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding
S	0006006	biological_process	glucose metabolic process
S	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
S	0050661	molecular_function	NADP binding
S	0051287	molecular_function	NAD binding
T	0006006	biological_process	glucose metabolic process
T	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
T	0050661	molecular_function	NADP binding
T	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 O 370

Chain	Residue
O	THR179
O	ASP181
O	NDP363

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 P 371

Chain	Residue
P	THR179
P	ASP181
P	ARG195

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 P 372

Chain	Residue
P	THR208
P	SER148
P	CYS149
P	THR150

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Q 373

Chain	Residue
Q	ASP181
Q	ARG195
Q	ARG231
Q	TYR361
Q	NDP365

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 R 374

Chain	Residue
R	THR179
R	ASP181
R	ARG195
R	NDP366

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 R 375

Chain	Residue
R	THR150
R	THR208
R	ARG231

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 S 376

Chain	Residue
S	THR179
S	ASP181
S	ARG195
S	ARG231
S	NDP367

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 S 377

Chain	Residue
S	SER148
S	CYS149
S	THR150
S	THR208
S	ARG231

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 T 378

Chain	Residue
T	ASP181
T	ARG231
T	TYR361
T	NDP368

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 T 379

Chain	Residue
T	SER148
T	CYS149
T	THR150
T	THR208
T	ALA210

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 S 380

Chain	Residue
S	GLU253
S	ASN256
S	ARG260
S	ASP275
S	SER294

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 R 381

Chain	Residue
R	CYS274

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 Q 382

Chain	Residue
Q	GLY138
Q	HIS139
Q	LYS331

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 T 383

Chain	Residue
S	GLU276
T	THR41
T	VAL57
T	LYS58
T	ILE59

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 Q 384

Chain	Residue
Q	LYS107
T	LYS248

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NDP O 363

Chain	Residue
O	PHE8
O	GLY9
O	ARG10
O	ILE11
O	ASN31
O	ARG77
O	GLY95
O	THR96
O	GLY97
O	THR119
O	CYS149
O	ASN313
O	GLU314
O	TYR317
O	SO4370

site_id	BC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NDP P 364

Chain	Residue
P	GLY7
P	GLY9
P	ARG10
P	ILE11
P	ASN31
P	ASP32
P	THR33
P	ASP76
P	ARG77
P	GLY95
P	GLY97
P	THR119
P	ALA120
P	CYS149
P	THR179
P	ASN313
P	GLU314
P	TYR317
Q	GLU362

site_id	BC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NDP Q 365

Chain	Residue
Q	GLU314
Q	SO4373
Q	GLY9
Q	ARG10
Q	ILE11
Q	ARG77
Q	GLY97
Q	THR119
Q	CYS149
Q	ASN313

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NDP R 366

Chain	Residue
O	GLU362
R	GLY9
R	ARG10
R	ILE11
R	ASP32
R	THR33
R	ARG77
R	THR96
R	GLY97
R	THR119
R	ALA120
R	THR179
R	ASN313
R	TYR317
R	SO4374

site_id	CC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE NDP S 367

Chain	Residue
S	GLY9
S	ARG10
S	ILE11
S	ASP32
S	THR33
S	ASP76
S	ARG77
S	GLY95
S	GLY97
S	THR119
S	ALA120
S	THR179
S	ASN313
S	GLU314
S	TYR317
S	SO4376

site_id	CC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE NDP T 368

Chain	Residue
T	GLY7
T	PHE8
T	GLY9
T	ARG10
T	ILE11
T	ASN31
T	ARG77
T	GLY95
T	THR96
T	GLY97
T	THR119
T	ALA120
T	CYS149
T	ASN313
T	GLU314
T	TYR317
T	SO4378

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
O	ALA147-LEU154
P	ALA147-LEU154

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10009","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17573533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Activates thiol group during catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11846565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12705826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15236965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17573533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
P	CYS149
P	HIS176

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
R	CYS149
R	HIS176

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
S	CYS149
S	HIS176

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
O	CYS149
O	HIS176

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
Q	CYS149
Q	HIS176

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
T	CYS149
T	HIS176

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)