2PJ9

CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	HIS69
A	GLU72
A	HIS196
A	281401

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 281 A 401

Chain	Residue
A	ARG145
A	HIS196
A	SER197
A	TYR198
A	SER207
A	TYR248
A	ASP255
A	THR268
A	GLU270
A	PHE279
A	ZN400
A	HOH433
A	HOH446
A	HOH452
A	HIS69
A	ARG71
A	GLU72
A	ARG127
A	ASN144

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Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIfMdcGfHArEwISHafcqwF

Chain	Residue	Details
A	PRO60-PHE82

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site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQMIlYPY

Chain	Residue	Details
A	HIS196-TYR206

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379

Chain	Residue	Details
A	GLU270

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379

Chain	Residue	Details
A	HIS69
A	GLU72
A	HIS196

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00730

Chain	Residue	Details
A	ARG127
A	SER197
A	TYR248
A	ASN144

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