2PJ1

CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B (3-Aminomethyl-phenyl)-[((R)-1-benzyloxycarbonylamino-2-methyl-propyl)-hydroxy-phosphinoyloxy]-acetic acid COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004181	molecular_function	metallocarboxypeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
C	0004181	molecular_function	metallocarboxypeptidase activity
C	0006508	biological_process	proteolysis
C	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	HIS69
A	GLU72
A	HIS196
A	578401

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 500

Chain	Residue
B	HIS69
B	GLU72
B	HIS196
B	578501

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 600

Chain	Residue
C	GLU72
C	HIS196
C	578601
C	HIS69

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 578 A 401

Chain	Residue
A	HIS69
A	ARG71
A	GLU72
A	ARG127
A	ASN144
A	ARG145
A	THR164
A	HIS196
A	SER197
A	TYR198
A	SER207
A	ILE247
A	TYR248
A	ASP255
A	THR268
A	GLU270
A	PHE279
A	ZN400
A	HOH420
A	HOH422

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 578 B 501

Chain	Residue
B	HIS69
B	ARG71
B	GLU72
B	ARG127
B	ASN144
B	ARG145
B	THR164
B	HIS196
B	SER197
B	TYR198
B	LEU203
B	SER207
B	TYR248
B	ASP255
B	THR268
B	GLU270
B	PHE279
B	ZN500
B	HOH529
B	HOH565

---

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 578 C 601

Chain	Residue
C	HIS69
C	ARG71
C	GLU72
C	ARG127
C	ASN144
C	ARG145
C	THR164
C	HIS196
C	SER197
C	TYR198
C	SER207
C	TYR248
C	ASP255
C	THR268
C	GLU270
C	PHE279
C	ZN600
C	HOH613
C	HOH693

---

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIfMdcGfHArEwISHafcqwF

Chain	Residue	Details
A	PRO60-PHE82

---

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQMIlYPY

Chain	Residue	Details
A	HIS196-TYR206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	882
Details	Domain: {"description":"Peptidase M14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00730","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
A	ARG127
A	GLU270

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
B	ARG127
B	GLU270

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
C	ARG127
C	GLU270

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
A	ARG71
A	GLU270
A	ARG127

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
B	ARG71
B	GLU270
B	ARG127

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
C	ARG71
C	GLU270
C	ARG127

---