2PHG

Model for VP16 binding to TFIIB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006352	biological_process	DNA-templated transcription initiation
A	0017025	molecular_function	TBP-class protein binding
A	0070897	biological_process	transcription preinitiation complex assembly

Functional Information from PROSITE/UniProt

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC

Chain	Residue	Details
A	GLY153-CYS168
A	GLY247-SER262

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Repeat: {"description":"1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	76
Details	Repeat: {"description":"2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	72
Details	Region: {"description":"Necessary for TATA box-bound TBP complex formation","evidences":[{"source":"PubMed","id":"8515820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8516311","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"12931194","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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