2PGL

Catalysis associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
B	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE N1C A 301

Chain	Residue
A	LEU124
A	THR221
A	PHE222
A	GLN226
A	HOH302
A	HOH334
A	HOH395
A	HOH417
A	HOH428
A	HOH474
A	TRP125
A	SER126
A	ARG127
A	LEU145
A	GLU146
A	TRP189
A	SER193
A	SER220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"7961800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r16

Chain	Residue	Details
A	GLN226
A	GLU146

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1r16

Chain	Residue	Details
B	GLN226
B	GLU146

---