2PFR
Human N-acetyltransferase 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004060 | molecular_function | arylamine N-acetyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0016407 | molecular_function | acetyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019707 | molecular_function | protein-cysteine S-acyltransferase activity |
| A | 0046990 | molecular_function | N-hydroxyarylamine O-acetyltransferase activity |
| B | 0004060 | molecular_function | arylamine N-acetyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0016407 | molecular_function | acetyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0019707 | molecular_function | protein-cysteine S-acyltransferase activity |
| B | 0046990 | molecular_function | N-hydroxyarylamine O-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | LYS184 |
| A | LYS185 |
| A | HIS186 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | LYS184 |
| B | LYS185 |
| B | HIS186 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | THR257 |
| A | ASN172 |
| A | PHE175 |
| A | LYS256 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 504 |
| Chain | Residue |
| A | ARG117 |
| A | SO4505 |
| B | LYS141 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 505 |
| Chain | Residue |
| A | LYS141 |
| B | ARG117 |
| B | SO4504 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 506 |
| Chain | Residue |
| A | GLU155 |
| A | ARG156 |
| A | HOH668 |
| B | GLN85 |
| B | THR87 |
| B | GLN111 |
| B | PRO196 |
| B | HOH709 |
| B | HOH715 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 507 |
| Chain | Residue |
| A | GLN85 |
| A | THR87 |
| A | PRO196 |
| A | HOH735 |
| A | HOH824 |
| B | GLU155 |
| B | ARG156 |
| B | HOH611 |
| B | HOH683 |
| B | HOH876 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE COA A 401 |
| Chain | Residue |
| A | CYS68 |
| A | ILE95 |
| A | PRO97 |
| A | VAL98 |
| A | THR103 |
| A | GLY104 |
| A | HIS107 |
| A | GLY124 |
| A | TYR208 |
| A | THR214 |
| A | SER215 |
| A | SER216 |
| A | PHE217 |
| A | SER287 |
| A | LEU288 |
| A | HOH716 |
| A | HOH749 |
| A | HOH795 |
| A | UNX1013 |
| site_id | AC9 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE COA B 401 |
| Chain | Residue |
| B | PHE37 |
| B | CYS68 |
| B | PHE93 |
| B | ILE95 |
| B | PRO97 |
| B | VAL98 |
| B | SER102 |
| B | THR103 |
| B | GLY104 |
| B | HIS107 |
| B | GLY124 |
| B | TYR208 |
| B | THR214 |
| B | SER216 |
| B | PHE217 |
| B | SER287 |
| B | LEU288 |
| B | HOH645 |
| B | HOH755 |
| B | HOH791 |
| B | HOH858 |
| B | UNX1014 |
| B | UNX1015 |
| B | UNX1019 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE UNX B 1001 |
| Chain | Residue |
| A | TRP159 |
| A | LEU194 |
| A | HOH696 |
| B | TRP159 |
| B | LEU194 |
| B | HOH620 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 1002 |
| Chain | Residue |
| A | ASN41 |
| A | ALA47 |
| A | MET48 |
| A | GLN70 |
| A | HOH632 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 1003 |
| Chain | Residue |
| A | ASP162 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 1004 |
| Chain | Residue |
| A | ARG62 |
| A | ARG64 |
| A | HOH649 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 1005 |
| Chain | Residue |
| B | GLY140 |
| B | LYS141 |
| B | CYS151 |
| B | LEU152 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1006 |
| Chain | Residue |
| A | LEU21 |
| A | GLU22 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 1007 |
| Chain | Residue |
| B | GLU49 |
| B | GLN70 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 1008 |
| Chain | Residue |
| A | HOH654 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1009 |
| Chain | Residue |
| A | LEU288 |
| A | THR289 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 1010 |
| Chain | Residue |
| A | SER102 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 1011 |
| Chain | Residue |
| B | THR289 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 1012 |
| Chain | Residue |
| B | ASP162 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 1013 |
| Chain | Residue |
| A | COA401 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 1014 |
| Chain | Residue |
| B | THR214 |
| B | COA401 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 1015 |
| Chain | Residue |
| B | COA401 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 1016 |
| Chain | Residue |
| A | ARG166 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1017 |
| Chain | Residue |
| A | LEU52 |
| A | PRO228 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 1019 |
| Chain | Residue |
| B | SER216 |
| B | SER287 |
| B | COA401 |
| B | HOH725 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 1021 |
| Chain | Residue |
| A | ILE138 |
| A | LYS141 |
| A | GLN143 |
| A | LEU152 |
| A | UNX1022 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 1022 |
| Chain | Residue |
| A | GLY140 |
| A | LYS141 |
| A | CYS151 |
| A | LEU152 |
| A | UNX1021 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 1023 |
| Chain | Residue |
| A | LEU239 |
| A | GLU254 |
| A | LYS256 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE UNX A 1024 |
| Chain | Residue |
| A | ILE138 |
| A | SER139 |
| B | ARG117 |
| B | ASN118 |
| B | GLU136 |
| B | HOH684 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1025 |
| Chain | Residue |
| A | ASP142 |
| B | ARG117 |
| site_id | DC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1026 |
| Chain | Residue |
| A | GLU167 |
| A | ASN249 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 1027 |
| Chain | Residue |
| A | GLN73 |
| A | MET88 |
| A | ILE199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17656365","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1e2t |
| Chain | Residue | Details |
| A | CYS68 | |
| A | HIS107 | |
| A | ASP122 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1e2t |
| Chain | Residue | Details |
| B | CYS68 | |
| B | HIS107 | |
| B | ASP122 |
