2PFQ

Manganese promotes catalysis in a DNA polymerase lambda-DNA crystal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG A 1294

Chain	Residue
A	ASP427
A	ASP429
A	NA1295
A	MN1297
A	DCP1438
A	PPV1439
A	HOH1602
P	DC7

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NA A 1295

Chain	Residue
A	ASP429
A	ASP490
A	MG1294
A	MN1296
A	DCP1438
P	DC6
P	DC7
P	HOH299
A	ASP427

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MN A 1296

Chain	Residue
A	ASP427
A	ASP429
A	NA1295
A	MN1297
A	DCP1438
A	PPV1439
A	HOH1602
P	DC7

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MN A 1297

Chain	Residue
A	ASP427
A	ASP429
A	ASP490
A	MG1294
A	MN1296
A	DCP1438
P	DC6
P	DC7
P	HOH299

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH1452
P	DA5

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE DCP A 1438

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	TYR505
A	PHE506
A	THR507
A	GLY508
A	ASN513
A	MG1294
A	NA1295
A	MN1296
A	MN1297
A	HOH1449
A	HOH1602
P	DC6
P	DC7
P	HOH28
P	HOH84
T	DG5

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PPV A 1439

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	MG1294
A	MN1296
A	HOH1449
A	HOH1602
P	DC7

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

---