Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2PFF

Structural Insights of Yeast Fatty Acid Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016746	molecular_function	acyltransferase activity
B	0004312	molecular_function	fatty acid synthase activity
B	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
B	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
B	0016409	molecular_function	palmitoyltransferase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016746	molecular_function	acyltransferase activity
E	0004312	molecular_function	fatty acid synthase activity
E	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
E	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006633	biological_process	fatty acid biosynthetic process
E	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
E	0016409	molecular_function	palmitoyltransferase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
G	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
G	0006633	biological_process	fatty acid biosynthetic process
G	0016746	molecular_function	acyltransferase activity
H	0004312	molecular_function	fatty acid synthase activity
H	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
H	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0004321	molecular_function	fatty-acyl-CoA synthase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0005835	cellular_component	fatty acid synthase complex
H	0006633	biological_process	fatty acid biosynthetic process
H	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
H	0016409	molecular_function	palmitoyltransferase activity
H	0016491	molecular_function	oxidoreductase activity
H	0016740	molecular_function	transferase activity
H	0016787	molecular_function	hydrolase activity
H	0016829	molecular_function	lyase activity
H	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PROSITE/UniProt

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
A	GLY1296-VAL1312

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For acetyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER274
E	SER274
H	SER274
D	CYS1305
D	HIS1542
D	HIS1583
G	CYS1305
G	HIS1542
G	HIS1583

site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: For malonyltransferase activity => ECO:0000250

Chain	Residue	Details
B	SER1808
E	SER1808
H	SER1808
D	SER1440
G	SER958
G	SER1440

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
B	MET1
E	MET1
H	MET1

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	UNK733
E	UNK733
H	UNK733

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	UNK1166
E	UNK1166
H	UNK1166

site_id	SWS_FT_FI6
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
B	UNK1409
E	UNK1409
H	UNK1409

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
A	ASP836
A	LYS843

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
D	ASP836
D	LYS843

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
G	ASP836
G	LYS843

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
A	TYR839
A	LYS843

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
D	TYR839
D	LYS843

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1qsg

Chain	Residue	Details
G	TYR839
G	LYS843

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)