2PER

Crystal Structure of Human Chloride Intracellular Channel protein 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005254	molecular_function	chloride channel activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006821	biological_process	chloride transport
A	0007165	biological_process	signal transduction
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0051099	biological_process	positive regulation of binding
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0098869	biological_process	cellular oxidant detoxification
A	1902476	biological_process	chloride transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MNB A 401

Chain	Residue
A	PHE110
A	CYS114
A	SER185
A	LEU186
A	LYS189
A	HOH412
A	HOH425
A	HOH438

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Note=After insertion into the membrane => ECO:0000255

Chain	Residue	Details
A	PHE32-VAL52

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