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2PE6

Non-covalent complex between human SUMO-1 and human Ubc9

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000795cellular_componentsynaptonemal complex
A0001221molecular_functiontranscription coregulator binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005643cellular_componentnuclear pore
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0007059biological_processchromosome segregation
A0007084biological_processmitotic nuclear membrane reassembly
A0008134molecular_functiontranscription factor binding
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0016925biological_processprotein sumoylation
A0019787molecular_functionubiquitin-like protein transferase activity
A0019789molecular_functionSUMO transferase activity
A0019899molecular_functionenzyme binding
A0030335biological_processpositive regulation of cell migration
A0032446biological_processprotein modification by small protein conjugation
A0036211biological_processprotein modification process
A0044388molecular_functionsmall protein activating enzyme binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0051168biological_processnuclear export
A0051301biological_processcell division
A0061656molecular_functionSUMO conjugating enzyme activity
A0071535molecular_functionRING-like zinc finger domain binding
A0106068cellular_componentSUMO ligase complex
A1903755biological_processpositive regulation of SUMO transferase activity
A1990234cellular_componenttransferase complex
B0001741cellular_componentXY body
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006281biological_processDNA repair
B0006355biological_processregulation of DNA-templated transcription
B0008076cellular_componentvoltage-gated potassium channel complex
B0008134molecular_functiontranscription factor binding
B0010621biological_processnegative regulation of transcription by transcription factor localization
B0015459molecular_functionpotassium channel regulator activity
B0016604cellular_componentnuclear body
B0016605cellular_componentPML body
B0016607cellular_componentnuclear speck
B0016925biological_processprotein sumoylation
B0019899molecular_functionenzyme binding
B0030578biological_processPML body organization
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031386molecular_functionprotein tag activity
B0031625molecular_functionubiquitin protein ligase binding
B0031647biological_processregulation of protein stability
B0031965cellular_componentnuclear membrane
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032880biological_processregulation of protein localization
B0034605biological_processcellular response to heat
B0042308biological_processnegative regulation of protein import into nucleus
B0043392biological_processnegative regulation of DNA binding
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0044388molecular_functionsmall protein activating enzyme binding
B0044389molecular_functionubiquitin-like protein ligase binding
B0045759biological_processnegative regulation of action potential
B0045892biological_processnegative regulation of DNA-templated transcription
B0050821biological_processprotein stabilization
B0060021biological_processroof of mouth development
B0071276biological_processcellular response to cadmium ion
B0086004biological_processregulation of cardiac muscle cell contraction
B0090204biological_processprotein localization to nuclear pore
B0097165cellular_componentnuclear stress granule
B0098978cellular_componentglutamatergic synapse
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B1901017biological_processnegative regulation of potassium ion transmembrane transporter activity
B1902260biological_processnegative regulation of delayed rectifier potassium channel activity
B1903169biological_processregulation of calcium ion transmembrane transport
B1990381molecular_functionubiquitin-specific protease binding
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNVyps.GtVCLsiL
ChainResidueDetails
APHE82-LEU97

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Interaction with PIAS2
ChainResidueDetails
BPHE36

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18707152, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER2
AVAL25
ALEU57

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
BSER9

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER32

site_idSWS_FT_FI5
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS7

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000269|PubMed:27068747
ChainResidueDetails
ASER71
BGLY97

site_idSWS_FT_FI7
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS16

site_idSWS_FT_FI8
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS17
ALYS101

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS23
BLYS39
BLYS45
BLYS46

site_idSWS_FT_FI10
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
ChainResidueDetails
BLYS25

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS37

227111

PDB entries from 2024-11-06

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