2PCU
Human carboxypeptidase A4 in complex with a cleaved hexapeptide.
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00132 |
| Number of Residues | 23 |
| Details | CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaVwLnaGiHSrEwISQataiwT |
| Chain | Residue | Details |
| A | PRO60-THR82 |
| site_id | PS00133 |
| Number of Residues | 11 |
| Details | CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLmYPY |
| Chain | Residue | Details |
| A | HIS196-TYR206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379 |
| Chain | Residue | Details |
| A | GLU270 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23746805, ECO:0007744|PDB:4BD9 |
| Chain | Residue | Details |
| A | ASN8 | |
| A | TYR12 | |
| A | HIS13 | |
| A | SER14 | |
| A | LYS85 | |
| A | ASP158 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17506531, ECO:0007744|PDB:2PCU |
| Chain | Residue | Details |
| A | GLU16 | |
| A | PHE52 | |
| A | ARG84 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:15738388, ECO:0000269|PubMed:16091843, ECO:0000269|PubMed:17506531, ECO:0000269|PubMed:22294694, ECO:0000269|PubMed:23746805, ECO:0007744|PDB:2BO9, ECO:0007744|PDB:2BOA, ECO:0007744|PDB:2PCU, ECO:0007744|PDB:4A94, ECO:0007744|PDB:4BD9 |
| Chain | Residue | Details |
| A | HIS69 | |
| A | GLU72 | |
| A | HIS196 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17506531, ECO:0000269|PubMed:23746805, ECO:0007744|PDB:2PCU, ECO:0007744|PDB:4BD9 |
| Chain | Residue | Details |
| A | SER136 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15738388, ECO:0000269|PubMed:16091843, ECO:0000269|PubMed:17506531, ECO:0007744|PDB:2BO9, ECO:0007744|PDB:2BOA, ECO:0007744|PDB:2PCU |
| Chain | Residue | Details |
| A | ASN148 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cbx |
| Chain | Residue | Details |
| A | ARG127 | |
| A | GLU270 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1cbx |
| Chain | Residue | Details |
| A | ARG71 | |
| A | GLU270 | |
| A | ARG127 |
