2PC9
Crystal Structure Of ATP-Dependent Phosphoenolpyruvate Carboxykinase From Thermus thermophilus HB8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| A | 0004612 | molecular_function | phosphoenolpyruvate carboxykinase (ATP) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0017076 | molecular_function | purine nucleotide binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| B | 0004612 | molecular_function | phosphoenolpyruvate carboxykinase (ATP) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0017076 | molecular_function | purine nucleotide binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| C | 0004612 | molecular_function | phosphoenolpyruvate carboxykinase (ATP) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0017076 | molecular_function | purine nucleotide binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| D | 0004612 | molecular_function | phosphoenolpyruvate carboxykinase (ATP) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0017076 | molecular_function | purine nucleotide binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00532 |
| Number of Residues | 16 |
| Details | PEPCK_ATP Phosphoenolpyruvate carboxykinase (ATP) signature. LIGDDEHgWsEdGVfN |
| Chain | Residue | Details |
| A | LEU249-ASN264 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00453 |
| Chain | Residue | Details |
| A | ARG52 | |
| B | ASP253 | |
| B | GLU281 | |
| B | ARG319 | |
| C | ARG52 | |
| C | TYR191 | |
| C | LYS197 | |
| C | ASP253 | |
| C | GLU281 | |
| C | ARG319 | |
| D | ARG52 | |
| A | TYR191 | |
| D | TYR191 | |
| D | LYS197 | |
| D | ASP253 | |
| D | GLU281 | |
| D | ARG319 | |
| A | LYS197 | |
| A | ASP253 | |
| A | GLU281 | |
| A | ARG319 | |
| B | ARG52 | |
| B | TYR191 | |
| B | LYS197 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16239727, ECO:0000269|Ref.3, ECO:0007744|PDB:1J3B, ECO:0007744|PDB:1XKV, ECO:0007744|PDB:2PC9 |
| Chain | Residue | Details |
| A | ARG130 | |
| D | ARG130 | |
| D | ASN131 | |
| D | GLY267 | |
| A | ASN131 | |
| A | GLY267 | |
| B | ARG130 | |
| B | ASN131 | |
| B | GLY267 | |
| C | ARG130 | |
| C | ASN131 | |
| C | GLY267 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16239727, ECO:0000269|Ref.3, ECO:0007744|PDB:1J3B, ECO:0007744|PDB:2PC9 |
| Chain | Residue | Details |
| A | PHE133 | |
| B | PHE133 | |
| C | PHE133 | |
| D | PHE133 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P22259 |
| Chain | Residue | Details |
| A | HIS216 | |
| B | HIS216 | |
| C | HIS216 | |
| D | HIS216 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00453, ECO:0000269|PubMed:16239727, ECO:0000269|Ref.3, ECO:0007744|PDB:1XKV, ECO:0007744|PDB:2PC9 |
| Chain | Residue | Details |
| A | GLY232 | |
| A | THR444 | |
| B | GLY232 | |
| B | THR444 | |
| C | GLY232 | |
| C | THR444 | |
| D | GLY232 | |
| D | THR444 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:16239727, ECO:0000305|Ref.3, ECO:0007744|PDB:1XKV, ECO:0007744|PDB:2PC9 |
| Chain | Residue | Details |
| A | ARG438 | |
| B | ARG438 | |
| C | ARG438 | |
| D | ARG438 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00453, ECO:0000269|PubMed:16239727, ECO:0000269|Ref.3 |
| Chain | Residue | Details |
| A | PHE439 | |
| B | PHE439 | |
| C | PHE439 | |
| D | PHE439 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| A | HIS216 | |
| A | ARG319 | |
| A | LYS238 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| B | HIS216 | |
| B | ARG319 | |
| B | LYS238 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| C | HIS216 | |
| C | ARG319 | |
| C | LYS238 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| D | HIS216 | |
| D | ARG319 | |
| D | LYS238 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| A | HIS216 | |
| A | ARG319 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| B | HIS216 | |
| B | ARG319 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| C | HIS216 | |
| C | ARG319 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| D | HIS216 | |
| D | ARG319 |
