2P82
Cysteine protease ATG4A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0019786 | molecular_function | protein-phosphatidylethanolamide deconjugating activity |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0019786 | molecular_function | protein-phosphatidylethanolamide deconjugating activity |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0019786 | molecular_function | protein-phosphatidylethanolamide deconjugating activity |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0019786 | molecular_function | protein-phosphatidylethanolamide deconjugating activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 1 |
| Chain | Residue |
| D | ARG59 |
| D | ARG59 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 2 |
| Chain | Residue |
| A | ARG230 |
| A | TYR240 |
| A | MET348 |
| A | HOH604 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 3 |
| Chain | Residue |
| B | TYR240 |
| B | ARG347 |
| B | MET348 |
| B | HOH399 |
| B | ASN175 |
| B | ARG230 |
| B | LEU231 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 4 |
| Chain | Residue |
| D | LEU229 |
| D | LEU231 |
| D | TYR240 |
| D | ARG347 |
| D | MET348 |
| D | HOH371 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 360 |
| Chain | Residue |
| A | GLN88 |
| A | CYS92 |
| A | ARG97 |
| A | PRO251 |
| A | GLN252 |
| A | SER253 |
| A | HOH569 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 360 |
| Chain | Residue |
| B | LEU32 |
| B | GLN88 |
| B | CYS92 |
| B | PRO251 |
| B | SER253 |
| B | LEU254 |
| B | HOH532 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 360 |
| Chain | Residue |
| C | LEU32 |
| C | GLN88 |
| C | CYS92 |
| C | ARG97 |
| C | PRO251 |
| C | GLN252 |
| C | SER253 |
| C | HOH508 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO D 360 |
| Chain | Residue |
| D | LEU32 |
| D | GLN88 |
| D | CYS92 |
| D | ARG97 |
| D | PRO251 |
| D | GLN252 |
| D | SER253 |
| D | LEU254 |
| D | HOH450 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 361 |
| Chain | Residue |
| D | GLN252 |
| D | PHE323 |
| D | CYS324 |
| D | LYS325 |
| D | ASP329 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 361 |
| Chain | Residue |
| A | TRP54 |
| A | HIS301 |
| A | LEU303 |
| A | GLN304 |
| A | HOH389 |
| C | GLN307 |
| C | ARG308 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 361 |
| Chain | Residue |
| B | TRP145 |
| B | PRO148 |
| B | PRO261 |
| B | ASP315 |
| B | HOH453 |
| B | HOH504 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 362 |
| Chain | Residue |
| A | TRP101 |
| A | GLN104 |
| A | GLN107 |
| A | HOH489 |
| C | ASN263 |
| C | HOH501 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 361 |
| Chain | Residue |
| C | TRP145 |
| C | PRO148 |
| C | PRO261 |
| C | ASP315 |
| C | HOH396 |
| C | HOH462 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 362 |
| Chain | Residue |
| C | LEU229 |
| C | TYR240 |
| C | ARG347 |
| C | MET348 |
| C | HOH406 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 363 |
| Chain | Residue |
| C | LYS156 |
| C | LEU160 |
| C | ALA168 |
| C | VAL169 |
| C | MET185 |
| C | HOH445 |
| C | HOH452 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 362 |
| Chain | Residue |
| D | TRP145 |
| D | PRO148 |
| D | PRO261 |
| D | ASP315 |
| D | HOH365 |
| D | HOH459 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:Q9Y4P1 |
| Chain | Residue | Details |
| A | CYS77 | |
| B | CYS77 | |
| C | CYS77 | |
| D | CYS77 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q9Y4P1 |
| Chain | Residue | Details |
| A | ASP279 | |
| A | HIS281 | |
| B | ASP279 | |
| B | HIS281 | |
| C | ASP279 | |
| C | HIS281 | |
| D | ASP279 | |
| D | HIS281 |
