Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2P6G

Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006499	biological_process	N-terminal protein myristoylation
A	0016746	molecular_function	acyltransferase activity
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006499	biological_process	N-terminal protein myristoylation
B	0016746	molecular_function	acyltransferase activity
C	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006499	biological_process	N-terminal protein myristoylation
C	0016746	molecular_function	acyltransferase activity
D	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006499	biological_process	N-terminal protein myristoylation
D	0016746	molecular_function	acyltransferase activity
E	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006499	biological_process	N-terminal protein myristoylation
E	0016746	molecular_function	acyltransferase activity
F	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006499	biological_process	N-terminal protein myristoylation
F	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE MYA A 601

Chain	Residue
A	HIS38
A	LEU171
A	CYS172
A	VAL173
A	ARG178
A	SER179
A	ARG181
A	LEU182
A	THR183
A	PRO184
A	ILE187
A	LYS39
A	THR191
A	TRP200
A	HIS201
A	TYR204
A	THR205
A	ILE208
A	LEU210
A	PHE425
A	PHE40
A	TRP41
A	TYR103
A	GLU105
A	ILE168
A	ASN169
A	PHE170

site_id	AC2
Number of Residues	31
Details	BINDING SITE FOR RESIDUE MYA B 602

Chain	Residue
B	HIS38
B	LYS39
B	PHE40
B	TRP41
B	TYR103
B	GLU105
B	ILE168
B	ASN169
B	PHE170
B	LEU171
B	CYS172
B	VAL173
B	ARG178
B	SER179
B	LYS180
B	ARG181
B	LEU182
B	THR183
B	PRO184
B	ILE187
B	THR191
B	VAL194
B	ASN195
B	TRP200
B	HIS201
B	ALA202
B	TYR204
B	THR205
B	ILE208
B	LEU210
B	PHE425

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE MYA C 603

Chain	Residue
C	HIS38
C	LYS39
C	PHE40
C	TRP41
C	VAL166
C	ILE168
C	ASN169
C	PHE170
C	LEU171
C	CYS172
C	VAL173
C	ARG178
C	SER179
C	ARG181
C	LEU182
C	THR183
C	ILE187
C	THR191
C	VAL194
C	ASN195
C	HIS201
C	TYR204
C	THR205
C	ILE208
C	LEU210
C	PHE425

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE MYA D 604

Chain	Residue
D	THR183
D	ILE187
D	THR191
D	ASN195
D	ILE199
D	TRP200
D	HIS201
D	TYR204
D	THR205
D	LEU210
D	PHE425
D	HIS38
D	LYS39
D	PHE40
D	TRP41
D	TYR103
D	GLU105
D	ILE168
D	PHE170
D	LEU171
D	VAL173
D	ARG178
D	SER179
D	LYS180
D	ARG181
D	LEU182

site_id	AC5
Number of Residues	28
Details	BINDING SITE FOR RESIDUE MYA E 605

Chain	Residue
E	HIS38
E	LYS39
E	PHE40
E	TRP41
E	TYR103
E	ILE168
E	ASN169
E	PHE170
E	LEU171
E	CYS172
E	VAL173
E	ARG178
E	SER179
E	LYS180
E	ARG181
E	LEU182
E	THR183
E	ILE187
E	THR191
E	ASN195
E	TRP200
E	HIS201
E	ALA202
E	TYR204
E	THR205
E	ILE208
E	LEU210
E	PHE425

site_id	AC6
Number of Residues	29
Details	BINDING SITE FOR RESIDUE MYA F 606

Chain	Residue
F	HIS38
F	LYS39
F	PHE40
F	TRP41
F	TYR103
F	GLU105
F	ILE168
F	ASN169
F	PHE170
F	LEU171
F	CYS172
F	VAL173
F	ARG178
F	SER179
F	LYS180
F	ARG181
F	LEU182
F	THR183
F	PRO184
F	THR191
F	ASN195
F	TRP200
F	HIS201
F	ALA202
F	TYR204
F	THR205
F	ILE208
F	LEU210
F	PHE425

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3LP C 703

Chain	Residue
C	PHE113
C	TYR115
C	TYR219
C	HIS221
C	PHE234
C	LEU332
C	PHE334
C	TYR349
C	ASN397
C	ASP417
C	GLY418
C	LEU455

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 3LP F 706

Chain	Residue
F	TYR115
F	TYR219
F	HIS221
F	PHE234
F	LEU332
F	PHE334
F	TYR349
F	ASN397
F	ASP417
F	GLY418
F	LEU455

Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK

Chain	Residue	Details
A	GLU167-LYS175

site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGpGDG

Chain	Residue	Details
A	LYS412-GLY418

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor; via carboxylate => ECO:0000269\|PubMed:11478885

Chain	Residue	Details
A	LEU455
B	LEU455
C	LEU455
D	LEU455
E	LEU455
F	LEU455

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	HIS38
B	HIS38
C	HIS38
D	HIS38
E	HIS38
F	HIS38

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 2nmt

Chain	Residue	Details
A	PHE170
A	LEU455
A	ASN169
A	LEU171

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 2nmt

Chain	Residue	Details
B	PHE170
B	LEU455
B	ASN169
B	LEU171

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 2nmt

Chain	Residue	Details
C	PHE170
C	LEU455
C	ASN169
C	LEU171

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 2nmt

Chain	Residue	Details
D	PHE170
D	LEU455
D	ASN169
D	LEU171

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 2nmt

Chain	Residue	Details
E	PHE170
E	LEU455
E	ASN169
E	LEU171

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 2nmt

Chain	Residue	Details
F	PHE170
F	LEU455
F	ASN169
F	LEU171

site_id	MCSA1
Number of Residues	5
Details	M-CSA 928

Chain	Residue	Details
A	ASN169	electrostatic stabiliser
A	PHE170	electrostatic stabiliser
A	LEU171	electrostatic stabiliser
A	THR205	electrostatic stabiliser
A	LEU455	proton shuttle (general acid/base)

site_id	MCSA2
Number of Residues	5
Details	M-CSA 928

Chain	Residue	Details
B	ASN169	electrostatic stabiliser
B	PHE170	electrostatic stabiliser
B	LEU171	electrostatic stabiliser
B	THR205	electrostatic stabiliser
B	LEU455	proton shuttle (general acid/base)

site_id	MCSA3
Number of Residues	5
Details	M-CSA 928

Chain	Residue	Details
C	ASN169	electrostatic stabiliser
C	PHE170	electrostatic stabiliser
C	LEU171	electrostatic stabiliser
C	THR205	electrostatic stabiliser
C	LEU455	proton shuttle (general acid/base)

site_id	MCSA4
Number of Residues	5
Details	M-CSA 928

Chain	Residue	Details
D	ASN169	electrostatic stabiliser
D	PHE170	electrostatic stabiliser
D	LEU171	electrostatic stabiliser
D	THR205	electrostatic stabiliser
D	LEU455	proton shuttle (general acid/base)

site_id	MCSA5
Number of Residues	5
Details	M-CSA 928

Chain	Residue	Details
E	ASN169	electrostatic stabiliser
E	PHE170	electrostatic stabiliser
E	LEU171	electrostatic stabiliser
E	THR205	electrostatic stabiliser
E	LEU455	proton shuttle (general acid/base)

site_id	MCSA6
Number of Residues	5
Details	M-CSA 928

Chain	Residue	Details
F	ASN169	electrostatic stabiliser
F	PHE170	electrostatic stabiliser
F	LEU171	electrostatic stabiliser
F	THR205	electrostatic stabiliser
F	LEU455	proton shuttle (general acid/base)

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)