2P6E
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006499 | biological_process | N-terminal protein myristoylation |
A | 0016746 | molecular_function | acyltransferase activity |
B | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006499 | biological_process | N-terminal protein myristoylation |
B | 0016746 | molecular_function | acyltransferase activity |
C | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006499 | biological_process | N-terminal protein myristoylation |
C | 0016746 | molecular_function | acyltransferase activity |
D | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006499 | biological_process | N-terminal protein myristoylation |
D | 0016746 | molecular_function | acyltransferase activity |
E | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006499 | biological_process | N-terminal protein myristoylation |
E | 0016746 | molecular_function | acyltransferase activity |
F | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006499 | biological_process | N-terminal protein myristoylation |
F | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE MYA A 601 |
Chain | Residue |
A | SER25 |
A | ASN169 |
A | PHE170 |
A | LEU171 |
A | CYS172 |
A | VAL173 |
A | ARG178 |
A | SER179 |
A | LYS180 |
A | ARG181 |
A | THR183 |
A | PHE27 |
A | ILE187 |
A | THR191 |
A | VAL194 |
A | HIS201 |
A | ALA202 |
A | THR205 |
A | ILE208 |
A | LEU210 |
A | PHE425 |
A | HIS38 |
A | LYS39 |
A | PHE40 |
A | TRP41 |
A | TYR103 |
A | GLU105 |
A | ILE168 |
site_id | AC2 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE MYA B 602 |
Chain | Residue |
B | SER25 |
B | PHE27 |
B | HIS38 |
B | LYS39 |
B | PHE40 |
B | TRP41 |
B | TYR103 |
B | ILE168 |
B | ASN169 |
B | PHE170 |
B | LEU171 |
B | VAL173 |
B | ARG178 |
B | SER179 |
B | LYS180 |
B | ARG181 |
B | LEU182 |
B | THR183 |
B | ILE187 |
B | THR191 |
B | VAL194 |
B | ASN195 |
B | TRP200 |
B | HIS201 |
B | TYR204 |
B | THR205 |
B | LEU210 |
B | PHE425 |
site_id | AC3 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE MYA C 603 |
Chain | Residue |
C | GLN29 |
C | HIS38 |
C | LYS39 |
C | PHE40 |
C | TRP41 |
C | TYR103 |
C | GLU105 |
C | ILE168 |
C | ASN169 |
C | PHE170 |
C | LEU171 |
C | CYS172 |
C | VAL173 |
C | ARG178 |
C | SER179 |
C | LYS180 |
C | ARG181 |
C | LEU182 |
C | THR183 |
C | PRO184 |
C | ILE187 |
C | THR191 |
C | HIS201 |
C | TYR204 |
C | THR205 |
C | ILE208 |
C | LEU210 |
C | PHE425 |
site_id | AC4 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE MYA D 604 |
Chain | Residue |
D | LYS180 |
D | ARG181 |
D | LEU182 |
D | THR183 |
D | ILE187 |
D | THR191 |
D | ILE199 |
D | TRP200 |
D | HIS201 |
D | ALA202 |
D | TYR204 |
D | THR205 |
D | LEU210 |
D | PHE425 |
D | SER25 |
D | PHE27 |
D | HIS38 |
D | LYS39 |
D | PHE40 |
D | TRP41 |
D | TYR103 |
D | ILE168 |
D | ASN169 |
D | PHE170 |
D | LEU171 |
D | CYS172 |
D | VAL173 |
D | ARG178 |
D | SER179 |
site_id | AC5 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE MYA E 605 |
Chain | Residue |
E | SER25 |
E | HIS38 |
E | LYS39 |
E | PHE40 |
E | TRP41 |
E | TYR103 |
E | ILE168 |
E | ASN169 |
E | PHE170 |
E | LEU171 |
E | CYS172 |
E | VAL173 |
E | ARG178 |
E | SER179 |
E | LYS180 |
E | ARG181 |
E | LEU182 |
E | THR183 |
E | PRO184 |
E | ILE187 |
E | THR191 |
E | ASN195 |
E | TRP200 |
E | HIS201 |
E | ALA202 |
E | TYR204 |
E | THR205 |
E | ILE208 |
E | LEU210 |
E | PHE425 |
site_id | AC6 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE MYA F 606 |
Chain | Residue |
F | HIS38 |
F | LYS39 |
F | PHE40 |
F | TRP41 |
F | TYR103 |
F | GLU105 |
F | ILE168 |
F | ASN169 |
F | PHE170 |
F | LEU171 |
F | VAL173 |
F | ARG178 |
F | SER179 |
F | LYS180 |
F | ARG181 |
F | LEU182 |
F | THR183 |
F | ILE187 |
F | ILE190 |
F | THR191 |
F | VAL194 |
F | ASN195 |
F | ALA202 |
F | TYR204 |
F | THR205 |
F | ILE208 |
F | LEU210 |
F | PHE425 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton acceptor; via carboxylate => ECO:0000269|PubMed:11478885 |
Chain | Residue | Details |
A | LEU455 | |
B | LEU455 | |
C | LEU455 | |
D | LEU455 | |
E | LEU455 | |
F | LEU455 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
A | HIS38 | |
B | HIS38 | |
C | HIS38 | |
D | HIS38 | |
E | HIS38 | |
F | HIS38 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 2nmt |
Chain | Residue | Details |
A | PHE170 | |
A | LEU455 | |
A | ASN169 | |
A | LEU171 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 2nmt |
Chain | Residue | Details |
B | PHE170 | |
B | LEU455 | |
B | ASN169 | |
B | LEU171 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 2nmt |
Chain | Residue | Details |
C | PHE170 | |
C | LEU455 | |
C | ASN169 | |
C | LEU171 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 2nmt |
Chain | Residue | Details |
D | PHE170 | |
D | LEU455 | |
D | ASN169 | |
D | LEU171 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 2nmt |
Chain | Residue | Details |
E | PHE170 | |
E | LEU455 | |
E | ASN169 | |
E | LEU171 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 2nmt |
Chain | Residue | Details |
F | PHE170 | |
F | LEU455 | |
F | ASN169 | |
F | LEU171 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
A | ASN169 | electrostatic stabiliser |
A | PHE170 | electrostatic stabiliser |
A | LEU171 | electrostatic stabiliser |
A | THR205 | electrostatic stabiliser |
A | LEU455 | proton shuttle (general acid/base) |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
B | ASN169 | electrostatic stabiliser |
B | PHE170 | electrostatic stabiliser |
B | LEU171 | electrostatic stabiliser |
B | THR205 | electrostatic stabiliser |
B | LEU455 | proton shuttle (general acid/base) |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
C | ASN169 | electrostatic stabiliser |
C | PHE170 | electrostatic stabiliser |
C | LEU171 | electrostatic stabiliser |
C | THR205 | electrostatic stabiliser |
C | LEU455 | proton shuttle (general acid/base) |
site_id | MCSA4 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
D | ASN169 | electrostatic stabiliser |
D | PHE170 | electrostatic stabiliser |
D | LEU171 | electrostatic stabiliser |
D | THR205 | electrostatic stabiliser |
D | LEU455 | proton shuttle (general acid/base) |
site_id | MCSA5 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
E | ASN169 | electrostatic stabiliser |
E | PHE170 | electrostatic stabiliser |
E | LEU171 | electrostatic stabiliser |
E | THR205 | electrostatic stabiliser |
E | LEU455 | proton shuttle (general acid/base) |
site_id | MCSA6 |
Number of Residues | 5 |
Details | M-CSA 928 |
Chain | Residue | Details |
F | ASN169 | electrostatic stabiliser |
F | PHE170 | electrostatic stabiliser |
F | LEU171 | electrostatic stabiliser |
F | THR205 | electrostatic stabiliser |
F | LEU455 | proton shuttle (general acid/base) |